-
1
-
-
0023894686
-
Flavin-containing monooxygenases: Catalytic mechanism and substrate specificity
-
D.M. Ziegler, Flavin-containing monooxygenases: Catalytic mechanism and substrate specificity, Drug Metab. Rev. 19 (1988) 1-32.
-
(1988)
Drug Metab. Rev.
, vol.19
, pp. 1-32
-
-
Ziegler, D.M.1
-
2
-
-
0027462628
-
Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
-
D.M. Ziegler, Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases, Annu. Rev. Pharmacol. Toxicol. 33 (1993) 179-199.
-
(1993)
Annu. Rev. Pharmacol. Toxicol.
, vol.33
, pp. 179-199
-
-
Ziegler, D.M.1
-
3
-
-
0023491184
-
A genetic polymorphism of the N-oxidation of trimethylamine in humans
-
M. Al-Waiz, R. Ayesh, S.C. Mitchell, J.R. Idle, R.L. Smith, A genetic polymorphism of the N-oxidation of trimethylamine in humans, Clin. Pharmcol. Ther. 42 (1987) 588-594.
-
(1987)
Clin. Pharmcol. Ther.
, vol.42
, pp. 588-594
-
-
Al-Waiz, M.1
Ayesh, R.2
Mitchell, S.C.3
Idle, J.R.4
Smith, R.L.5
-
4
-
-
0015590901
-
Dimethylaniline N-oxidase and aminopyrene N-demethylase activities of human liver tissue
-
M.S. Gold, D.M. Ziegler, Dimethylaniline N-oxidase and aminopyrene N-demethylase activities of human liver tissue, Xenobiotica 3 (1973) 179-189.
-
(1973)
Xenobiotica
, vol.3
, pp. 179-189
-
-
Gold, M.S.1
Ziegler, D.M.2
-
5
-
-
0023127466
-
Flavin-containing monooxygenase activity in human liver microsomes
-
M.E. McManus, I. Stupans, W. Burgess, J.A. Koenig, P de la M. Hall, D.J. Birkett, Flavin-containing monooxygenase activity in human liver microsomes, Drug Metab. Dispos. 15 (1986) 256-261.
-
(1986)
Drug Metab. Dispos.
, vol.15
, pp. 256-261
-
-
McManus, M.E.1
Stupans, I.2
Burgess, W.3
Koenig, J.A.4
De La Hall, P.M.5
Birkett, D.J.6
-
6
-
-
0025181827
-
Evidence for the presence of distinct flavin-containing monooxygenases in human tissues
-
A. Lemoine, M. Johann, T. Cresteil, Evidence for the presence of distinct flavin-containing monooxygenases in human tissues, Arch. Biochem. Biophys. 276 (1990) 336-342.
-
(1990)
Arch. Biochem. Biophys.
, vol.276
, pp. 336-342
-
-
Lemoine, A.1
Johann, M.2
Cresteil, T.3
-
7
-
-
0029381244
-
Some aspects of the role of cytochrome P-450 isozymes in the N-oxidative transformation of secondary and tertiary amine compounds
-
P. Hlavica, M. Lehnerer, Some aspects of the role of cytochrome P-450 isozymes in the N-oxidative transformation of secondary and tertiary amine compounds, J. Biochem. Toxicol. 10 (1995) 275-285.
-
(1995)
J. Biochem. Toxicol.
, vol.10
, pp. 275-285
-
-
Hlavica, P.1
Lehnerer, M.2
-
8
-
-
0014057028
-
N-oxide formation: A new route for inactivation of the antihistaminic chlorcyclizine
-
R. Kuntzman, A. Phillips, I. Tsai, A. Klutch, J.J. Burns, N-oxide formation: a new route for inactivation of the antihistaminic chlorcyclizine, J. Pharmacol. Exp. Therap. 155 (1967) 337-344.
-
(1967)
J. Pharmacol. Exp. Therap.
, vol.155
, pp. 337-344
-
-
Kuntzman, R.1
Phillips, A.2
Tsai, I.3
Klutch, A.4
Burns, J.J.5
-
9
-
-
0014115863
-
The metabolism of chlorpromazine by liver microsomal enzyme systems
-
P.F. Coccia, W.W. Westerfeld, The metabolism of chlorpromazine by liver microsomal enzyme systems, J. Pharmacol. Exp. Ther. 157 (1967) 446-458.
-
(1967)
J. Pharmacol. Exp. Ther.
, vol.157
, pp. 446-458
-
-
Coccia, P.F.1
Westerfeld, W.W.2
-
10
-
-
0027198580
-
Metabolism of the antimammary cancer agent tamoxifen II. Flavin-containing monooxygenase-mediated N-oxidation
-
C. Mani, E. Hodgson, D. Kupfer, Metabolism of the antimammary cancer agent tamoxifen II. Flavin-containing monooxygenase-mediated N-oxidation, Drug Metab. Dispos. 21 (1993) 657-661.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 657-661
-
-
Mani, C.1
Hodgson, E.2
Kupfer, D.3
-
11
-
-
0001847126
-
Emergence of the flavin-containing monooxygenase gene family
-
E. Hodgson, J.R. Bend, R.M. Philpot (Eds.), Toxicology Communications, Raleigh, NC
-
M. Lawton, R.M. Philpot, Emergence of the flavin-containing monooxygenase gene family, Rev. Biochem. Toxicol.; E. Hodgson, J.R. Bend, R.M. Philpot (Eds.), Toxicology Communications, vol. 11, Raleigh, NC, 1995, pp. 1-27.
-
(1995)
Rev. Biochem. Toxicol.
, vol.11
, pp. 1-27
-
-
Lawton, M.1
Philpot, R.M.2
-
12
-
-
0028917419
-
The molecular biology of the flavin-containing monooxygenases of man
-
I.R. Philips, C. Dolphin, P. Clair, M.R. Hadley, A.J. Hutt, R. McCombie, R.L. Smith, E.A. Shephard, The molecular biology of the flavin-containing monooxygenases of man, Chem.-Biol. Interact. 96 (1995) 17-32.
-
(1995)
Chem.-Biol. Interact.
, vol.96
, pp. 17-32
-
-
Philips, I.R.1
Dolphin, C.2
Clair, P.3
Hadley, M.R.4
Hutt, A.J.5
McCombie, R.6
Smith, R.L.7
Shephard, E.A.8
-
13
-
-
0028849826
-
Molecular cloning of the flavin-containing monooxygenase (Form II) form adult human liver
-
N. Lomri, Q. Gu, J.R. Cashman, Molecular cloning of the flavin-containing monooxygenase (Form II) form adult human liver., Proc. Natl. Acad. Sci. USA 92 (1995) 9910.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9910
-
-
Lomri, N.1
Gu, Q.2
Cashman, J.R.3
-
14
-
-
0027909072
-
Purification of macaque liver flavin-containing monooxygenase: A form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver
-
A.J.M. Sadeque, K.E. Thummel, A.E. Rettie, Purification of macaque liver flavin-containing monooxygenase: A form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver, Biochim. Biophys. Acta 1162 (1993) 127-134.
-
(1993)
Biochim. Biophys. Acta
, vol.1162
, pp. 127-134
-
-
Sadeque, A.J.M.1
Thummel, K.E.2
Rettie, A.E.3
-
15
-
-
0027261530
-
Chemical, enzymatic, and human enantioselective S-oxidation of cimetidine
-
J.R. Cashman, S.B. Park, Z-C. Yang, C.B. Washington, D.Y. Gomex, K.M. Giacomini, C.M. Brett, Chemical, enzymatic, and human enantioselective S-oxidation of cimetidine, Drug Metab. Dispos. 21 (1993) 587-597.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 587-597
-
-
Cashman, J.R.1
Park, S.B.2
Yang, Z.-C.3
Washington, C.B.4
Gomex, D.Y.5
Giacomini, K.M.6
Brett, C.M.7
-
16
-
-
0028279350
-
Cloning, sequencing, and characterization of flavin-containing monooxygenases FMO3 and FMO4 from rabbit
-
V.B. Burnett, M.P. Lawton, R.M. Philpot, Cloning, sequencing, and characterization of flavin-containing monooxygenases FMO3 and FMO4 from rabbit, J. Biol. Chem. 269 (1994) 14314-14322.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14314-14322
-
-
Burnett, V.B.1
Lawton, M.P.2
Philpot, R.M.3
-
17
-
-
0028280415
-
Isolation and structure of a third form of liver microsomal flavin monooxygenase
-
J. Ozols, Isolation and structure of a third form of liver microsomal flavin monooxygenase, Biochemistry 33 (1994) 3751-3757.
-
(1994)
Biochemistry
, vol.33
, pp. 3751-3757
-
-
Ozols, J.1
-
18
-
-
0030249888
-
Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: Immunochemical and kinetic evidence for FMO3 being the major catalyst
-
R.J. Krause, S.L. Ripp, P.J. Sausen, L. Overby, R.M. Philpot, A.A. Elfarra, Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: Immunochemical and kinetic evidence for FMO3 being the major catalyst, Arch. Biochem. Biophys. 333 (1996) 109-116.
-
(1996)
Arch. Biochem. Biophys.
, vol.333
, pp. 109-116
-
-
Krause, R.J.1
Ripp, S.L.2
Sausen, P.J.3
Overby, L.4
Philpot, R.M.5
Elfarra, A.A.6
-
19
-
-
0027185830
-
Expression in Escherichia coli of the flavin-containing monooxygenase D (Form II) from adult human liver: Determination of a distinct tertiary amine substrate specificity
-
N. Lomri, Z. Yang, J.R. Cashman, Expression in Escherichia coli of the flavin-containing monooxygenase D (Form II) from adult human liver: Determination of a distinct tertiary amine substrate specificity, Chem. Res. Toxicol. 6 (1993) 425-429.
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 425-429
-
-
Lomri, N.1
Yang, Z.2
Cashman, J.R.3
-
20
-
-
0028343305
-
Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: Studies with rabbit FMO1, FMO2, FMO3 and FMO5 expressed in Escherichia coli
-
A.E. Rettie, M.P. Lawton, A.J.M. Sadeque, G.P. Meier, R.M. Philpot, Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: Studies with rabbit FMO1, FMO2, FMO3 and FMO5 expressed in Escherichia coli, Arch. Biochem. Biophys. 311 (1994) 369-377.
-
(1994)
Arch. Biochem. Biophys.
, vol.311
, pp. 369-377
-
-
Rettie, A.E.1
Lawton, M.P.2
Sadeque, A.J.M.3
Meier, G.P.4
Philpot, R.M.5
-
21
-
-
0027154768
-
Stereo- and regio-selective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes
-
J.R. Cashman, Z. Yang, L. Yang, S.A. Wrighton, Stereo- and regio-selective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes, Drug Metab. Dispos. 21 (1993) 492-501.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 492-501
-
-
Cashman, J.R.1
Yang, Z.2
Yang, L.3
Wrighton, S.A.4
-
22
-
-
0026473006
-
Stereoselective sulfoxidation by human flavin-containing monooxygenase: Catalytic diversity between hepatic fetal and renal forms
-
A.J.M. Sadeque, A.C. Eddy, G.P. Meier, A.E. Rettie, Stereoselective sulfoxidation by human flavin-containing monooxygenase: catalytic diversity between hepatic fetal and renal forms, Drug Metab. Dispos. 20 (1992) 832-839.
-
(1992)
Drug Metab. Dispos.
, vol.20
, pp. 832-839
-
-
Sadeque, A.J.M.1
Eddy, A.C.2
Meier, G.P.3
Rettie, A.E.4
-
23
-
-
0028930879
-
Characterization of flavin-containing monooxygenase five (FMO5) from human and guinea pig: Evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog
-
L.H. Overby, A.R. Buckpitt, M.P. Lawton, E. Atta-Asafo-Adjei, J. Schulze, R.M. Philpot, Characterization of flavin-containing monooxygenase five (FMO5) from human and guinea pig: Evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog, Arch. Biochem. Biophys. 317 (1995) 275-284.
-
(1995)
Arch. Biochem. Biophys.
, vol.317
, pp. 275-284
-
-
Overby, L.H.1
Buckpitt, A.R.2
Lawton, M.P.3
Atta-Asafo-Adjei, E.4
Schulze, J.5
Philpot, R.M.6
-
24
-
-
0030063145
-
Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3, and FMO4
-
C.T. Dolphin, E.A. Cullingford, E.A. Shephard, R.L. Smith, I.R. Phillips, Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3, and FMO4, Eur. J. Biochem. 235 (1996) 683-689.
-
(1996)
Eur. J. Biochem.
, vol.235
, pp. 683-689
-
-
Dolphin, C.T.1
Cullingford, E.A.2
Shephard, E.A.3
Smith, R.L.4
Phillips, I.R.5
-
25
-
-
0020793569
-
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
-
A.P. Feinberg, B. Vogelstein, A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity, Anal. Biochem. 132 (1983) 6-13.
-
(1983)
Anal. Biochem.
, vol.132
, pp. 6-13
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
27
-
-
0021760092
-
A comprehensive set of sequence analysis programs for the VAX
-
J. Devereux, P. Haeberli, O. Smithies, A comprehensive set of sequence analysis programs for the VAX, Nucleic Acids Res. 12 (1984) 387-395.
-
(1984)
Nucleic Acids Res.
, vol.12
, pp. 387-395
-
-
Devereux, J.1
Haeberli, P.2
Smithies, O.3
-
28
-
-
0029838187
-
Expression and characterization of a modified flavin-containing monooxygenase 4 from humans
-
K. Itagaki, G.T. Carver, R.M. Philpot, Expression and characterization of a modified flavin-containing monooxygenase 4 from humans, J. Biol. Chem. 271 (1996) 20102-20107.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 20102-20107
-
-
Itagaki, K.1
Carver, G.T.2
Philpot, R.M.3
-
30
-
-
0027466902
-
Functional characterization of flavin-containing monooxygenase 1B1 expressed in Saccharomyces cerevisiae and Escherichia coli and analysis of proposed FAD- And membrane-binding domains
-
M.P. Lawton, R.M. Philpot, Functional characterization of flavin-containing monooxygenase 1B1 expressed in Saccharomyces cerevisiae and Escherichia coli and analysis of proposed FAD- and membrane-binding domains, J. Biol. Chem. 268 (1993) 5728-5734.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 5728-5734
-
-
Lawton, M.P.1
Philpot, R.M.2
-
31
-
-
0021141593
-
Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diurnal conditions
-
A. Dixit, T.E. Roche, Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diurnal conditions, Arch. Biochem. Biophys. 233 (1984) 50-63.
-
(1984)
Arch. Biochem. Biophys.
, vol.233
, pp. 50-63
-
-
Dixit, A.1
Roche, T.E.2
-
32
-
-
0023852362
-
Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs
-
R. Gasser, M. Negishi, R.M. Philpot, Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs, Mol. Pharmacol. 32 (1988) 22-30.
-
(1988)
Mol. Pharmacol.
, vol.32
, pp. 22-30
-
-
Gasser, R.1
Negishi, M.2
Philpot, R.M.3
-
33
-
-
0018639079
-
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
-
J.M. Chirgwin, A.E. Przybyla, R.J. MacDonald, W.J. Rutter, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry 18 (1979) 5294-5299.
-
(1979)
Biochemistry
, vol.18
, pp. 5294-5299
-
-
Chirgwin, J.M.1
Przybyla, A.E.2
MacDonald, R.J.3
Rutter, W.J.4
-
34
-
-
0016207067
-
Ribonucleic acid isolated by cesium chloride centrifugation
-
V. Glisin, R. Crkvenjakov, C. Byus, Ribonucleic acid isolated by cesium chloride centrifugation, Biochemistry 13 (1974) 2633-2637.
-
(1974)
Biochemistry
, vol.13
, pp. 2633-2637
-
-
Glisin, V.1
Crkvenjakov, R.2
Byus, C.3
-
35
-
-
0015356037
-
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose
-
H. Aviv, P. Leder, Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose, Proc. Natl. Acad. Sci. USA 69 (1972) 1408-1412.
-
(1972)
Proc. Natl. Acad. Sci. USA
, vol.69
, pp. 1408-1412
-
-
Aviv, H.1
Leder, P.2
-
36
-
-
0017281820
-
Methylmercury as a reversible denaturing agent for agarose gel electrophoresis
-
J.M. Bailey, N. Davidson, Methylmercury as a reversible denaturing agent for agarose gel electrophoresis, Anal. Biochem. 70 (1976) 75-85.
-
(1976)
Anal. Biochem.
, vol.70
, pp. 75-85
-
-
Bailey, J.M.1
Davidson, N.2
-
37
-
-
0015853344
-
Maturation of the head of bacteriophage T4 I. DNA packaging events
-
U.K. Laernmli, M. Favre, Maturation of the head of bacteriophage T4 I. DNA packaging events, J. Mol. Biol. 80 (1973) 575-599.
-
(1973)
J. Mol. Biol.
, vol.80
, pp. 575-599
-
-
Laernmli, U.K.1
Favre, M.2
-
38
-
-
0009482260
-
Electrophoretic transfer of proteins from polyacylamide gels to nitrocellulose sheets: Procedure and some applications
-
H. Towbin, T. Staehelin, J. Gordon, Electrophoretic transfer of proteins from polyacylamide gels to nitrocellulose sheets: procedure and some applications, Proc. Natl. Acad. Sci. USA 76 (1979) 4350-4354.
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 4350-4354
-
-
Towbin, H.1
Staehelin, T.2
Gordon, J.3
-
39
-
-
0015881843
-
A rapid micromethod for determination of FMN and FAD mixtures
-
E.J. Faeder, L.M. Siegel, A rapid micromethod for determination of FMN and FAD mixtures, Anal. Biochem. 53 (1973) 332-336.
-
(1973)
Anal. Biochem.
, vol.53
, pp. 332-336
-
-
Faeder, E.J.1
Siegel, L.M.2
-
40
-
-
71849104860
-
Protein measurement with Folin phenol reagent
-
O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, Protein measurement with Folin phenol reagent, J. Biol. Chem. 193 (1951) 265-275.
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
41
-
-
0027756106
-
In vitro methods for assessing human hepatic drug metabolism: Their use in drug development
-
S.A. Wrighton, M. Vandenbranden, J.C. Stevens, L.A. Shipley, B.J. Ring, A.E. Rettie, J.R. Cashman, In vitro methods for assessing human hepatic drug metabolism: their use in drug development, Drug Metabol. Rev. 25 (1993) 453-484.
-
(1993)
Drug Metabol. Rev.
, vol.25
, pp. 453-484
-
-
Wrighton, S.A.1
Vandenbranden, M.2
Stevens, J.C.3
Shipley, L.A.4
Ring, B.J.5
Rettie, A.E.6
Cashman, J.R.7
-
42
-
-
0021382844
-
Quantitation of rabbit cytochrome P-450, form 2, in microsomal preparations bound directly to nitrocellulose paper using a modified peroxidase-immunostaining procedure
-
B.A. Domin, C.J. Serabjit-Singh, R.M. Philpot, Quantitation of rabbit cytochrome P-450, form 2, in microsomal preparations bound directly to nitrocellulose paper using a modified peroxidase-immunostaining procedure, Anal. Biochem. 136 (1984) 390-396.
-
(1984)
Anal. Biochem.
, vol.136
, pp. 390-396
-
-
Domin, B.A.1
Serabjit-Singh, C.J.2
Philpot, R.M.3
-
43
-
-
0013029364
-
A consideration of the enzymology underlying ranitidine metabolism and drug interactions
-
D.M. Cross, A consideration of the enzymology underlying ranitidine metabolism and drug interactions, J. Biopharm. Sci. 2 (1991) 339-377.
-
(1991)
J. Biopharm. Sci.
, vol.2
, pp. 339-377
-
-
Cross, D.M.1
-
44
-
-
0027494529
-
Regio-and stereo-selective oxygenations by adult human liver flavin-containing monooxygenase 3. Comparison with forms 1 and 2
-
N. Lomri, Z. Yang, J.R. Cashman, Regio-and stereo-selective oxygenations by adult human liver flavin-containing monooxygenase 3. Comparison with forms 1 and 2, Chem. Res. Toxicol. 6 (1993) 800-807.
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 800-807
-
-
Lomri, N.1
Yang, Z.2
Cashman, J.R.3
-
45
-
-
0027315840
-
Cloning, sequencing, distribution and expression of a mammalian flavin-containing monooxygenase from a third gene subfamily
-
E. Atta-Asafo-Adjei, M.P. Lawton, R.M. Philpot, Cloning, sequencing, distribution and expression of a mammalian flavin-containing monooxygenase from a third gene subfamily, J. Biol. Chem. 268 (1993) 9681-9689.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 9681-9689
-
-
Atta-Asafo-Adjei, E.1
Lawton, M.P.2
Philpot, R.M.3
-
46
-
-
0027185830
-
Expression in Escherichia coli of the flavin-containing monooxygenase D (Form II) from adult human liver: Determination of a distinct tertiary amine substrate specificity
-
N. Lomri, Z. Yang, J.R. Cashman, Expression in Escherichia coli of the flavin-containing monooxygenase D (Form II) from adult human liver: Determination of a distinct tertiary amine substrate specificity, Chem. Res. Toxicol. 6 (1993) 425-429.
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 425-429
-
-
Lomri, N.1
Yang, Z.2
Cashman, J.R.3
|