Quantitative analysis of FMO gene mRNA levels in human tissues

Drug Metabolism and Disposition

Volumn 34, Issue 1, 2006, Pages 19-26

  Zhang, Jun ^a   Cashman, John R ^a  

^a HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLANILINE MONOOXYGENASE; DIMETHYLANILINE MONOOXYGENASE 1; DIMETHYLANILINE MONOOXYGENASE 2; DIMETHYLANILINE MONOOXYGENASE 3; DIMETHYLANILINE MONOOXYGENASE 4; DIMETHYLANILINE MONOOXYGENASE 5; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN TISSUE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENZYME REGULATION; FEMALE; FETUS; FETUS LIVER; GENETIC ANALYSIS; GROUPS BY AGE; HUMAN; HUMAN TISSUE; INFANT; KIDNEY; LIVER; LUNG; MALE; METHODOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; STEADY STATE; TISSUE DISTRIBUTION;

AGING; BRAIN; DOWN-REGULATION; FEMALE; HUMANS; INTESTINE, SMALL; ISOENZYMES; KIDNEY; LIVER; LUNG; MALE; OXYGENASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 29944437885     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.006171     Document Type: Article

References (32)

1. Bhagwat SV, Bhamre S, Boyd MR, and Ravindranath V (1996) Cerebral metabolism of imipramine and a purified flavin-containing monooxygenase from human brain. Neuropsychopharmacology 15:133-142.
2. Bhamre S, Bhagwat SV, Shankar SK, Boyd MR, and Ravindranath V (1995) Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomes. Brain Res 672:276-280.
3. Bhamre S, Bhagwat SV, Shankar SK, Williams DE, and Ravindranath V (1993) Cerebral flavin-containing monooxygenase-mediated metabolism of antidepressants in brain: immunochemical properties and immunocytochemical localization. J Pharmacol Exp Ther 267:555-559.
4. Blake BL, Philpot RM, Levi PE, and Hodgson E (1996) Xenobiotic biotransforming enzymes in the central nervous system: an isoform of flavin-containing monooxygenase (FMO4) is expressed in rabbit brain. Chem-Biol Interact 99:253-261.
5. Cashman JR (1995) Structural and catalytic properties of the mammalian flavin-containing monooxygenase. Chem Res Toxicol 8:166-181.
6. Cashman JR and Zhang J (2002) Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab Dispos 30:1043-1052.
7. Cherrington NJ, Cao Y, Cherrington JW, Rose RL, and Hodgson E (1998) Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5. Xenobiotica 28:673-682.
8. Dolphin CT, Cullingford TE, Shephard EA, Smith RL, and Phillips IR (1996) Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04. Eur J Biochem 235:683-689.
9. Hernandez D, Janmohamed A, Chandan P, Phillips IR, and Shephard EA (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. Pharmacogenetics 14:117-130.
10. Hines RN, Cashman JR, Philpot RM, Williams DE, and Ziegler DM (1994) The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. Toxicol Appl Pharmacol 125:1-6.
11. Hines RN, Hopp KA, Franco J, Saeian K, and Begun FP (2002) Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase. Mol Pharmacol 62:320-325.
12. Hines RN, Luo Z, Hopp KA, Cabacungan ET, Koukouritaki SB, and McCarver DG (2003) Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). J Pharmacol Exp Ther 306:1210-1218.
13. Holbrook JA, Neu-Yilik G, Hentze MW, and Kulozik AE (2004) Nonsense-mediated decay approaches the clinic. Nat Genet 36:801-808.
14. Janmohamed A, Hernandez D, Phillips IR, and Shephard EA (2004) Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (FMOs). Biochem Pharmacol 68:73-83.
15. Kawaji A, Miki T, and Takabatake E (1995) Partial purification and substrate specificity of flavin-containing monooxygenase from rat brain microsomes. Biol Pharm Bull 18:1657-1659.
16. Kim YM and Ziegler DM (2000) Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1. Drug Metab Dispos 28:1003-1006.
17. Koukouritaki SB, Poch MT, Cabacungan ET, McCarver DG, and Hines RN (2005) Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. Mol Pharmacol 68:383-392.
18. Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, and Hines RN (2002) Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. Pediatr Res 51:236-243.
19. Krueger SK, Siddens LK, Martin SR, Yu Z, Pereira CB, Cabacungan ET, Hines RN, Ardlie KG, Raucy JL, and Williams DE (2004) Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent. Drug Metab Dispos 32:1337-1340.
20. Larsen-Su S, Krueger SK, Yueh MF, Lee MY, Shehin SE, Hines RN, and Williams DE (1999) Flavin-containing monooxygenase isoform 2: developmental expression in fetal and neonatal rabbit lung. J Biochem Mol Toxicol 13:187-193.
21. Lattard V, Longin-Sauvageon C, and Benoit E (2003) Cloning, sequencing and tissue distribution of rat flavin-containing monooxygenase 4: two different forms are produced by tissue-specific alternative splicing. Mol Pharmacol 63:253-261.
22. Lattard V, Zhang J, and Cashman JR (2004) Alternative processing events in human FMO genes. Mol Pharmacol 65:1517-1525.
23. Ohmi N, Yoshida H, Endo H, Hasegawa M, Akimoto M, and Higuchi S (2003) S-oxidation of S-methyl-esonarimod by flavin-containing monooxygenases in human liver microsomes. Xenobiotica 33:1221-1231.
24. Overby LH, Buckpitt AR, Lawton MP, Atta-Asafo-Adjei E, Schulze J, and Philpot RM (1995) Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. Arch Biochem Biophys 317:275-284.
25. Overby LH, Carver GC, and Philpot RM (1997) Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. Chem-Biol Interact 106:29-45.
26. Rettie AE, Lawton MP, Sadeque AJ, Meier GP, and Philpot RM (1994) Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: studies with rabbit FMO1, FMO2, FMO3 and FMO5 expressed in Escherichia coli. Arch Biochem Biophys 311:369-377.
27. Shehin-Johnson SE, Palmer KC, and Hines RN (1996) Identification of tissue-specific DNase I hypersensitive sites in the rabbit flavin-containing monooxygenase form 2 gene. Drug Metab Dispos 24:891-898.
28. Shehin-Johnson SE, Williams DE, Larsen-Su S, Stresser DM, and Hines RN (1995) Tissue-specific expression of flavin-containing monooxygenase (FMO) forms 1 and 2 in the rabbit. J Pharmacol Exp Ther 272:1293-1299.
29. Thein SL, Hesketh C, Taylor P, Temperley IJ, Hutchinson RM, Old JM, Wood WG, Clegg JB, and Weatherall DJ (1990) Molecular basis for dominantly inherited inclusion body betathalassemia. Proc Natl Acad Sci USA 87:3924-3928.
30. Whetstine JR, Yueh MF, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, et al. (2000) Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans. Toxicol Appl Pharmacol 168:216-224.
31. Yeung CK, Lang DH, Thummel KE, and Rettie AE (2000) Immunoquantitation of FMO1 in human liver, kidney and intestine. Drug Metab Dispos 28:1107-1111.
32. Ziegler DM (1988) Flavin-containing monooxygenases: catalytic mechanism and substrate specificities. Drug Metab Rev 19:1-32.