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Volumn 332, Issue 1, 2010, Pages 202-209

Nicotine metabolism in African Americans and European Americans: Variation in glucuronidation by ethnicity and UGT2B10 haplotype

Author keywords

[No Author keywords available]

Indexed keywords

COTININE; DRUG METABOLITE; GLUCURONIDE; NICOTINE;

EID: 73949104432     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.159855     Document Type: Article
Times cited : (52)

References (39)
  • 1
    • 0032824167 scopus 로고    scopus 로고
    • Nicotine addiction
    • Benowitz NL (1999) Nicotine addiction. Prim Care 26:611-631.
    • (1999) Prim Care , vol.26 , pp. 611-631
    • Benowitz, N.L.1
  • 2
    • 0027958225 scopus 로고
    • Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
    • Benowitz NL, Jacob P 3rd, Fong I, and Gupta S (1994) Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 268:296-303.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 296-303
    • Benowitz, N.L.1    Jacob 3rd, P.2    Fong, I.3    Gupta, S.4
  • 3
    • 0032705773 scopus 로고    scopus 로고
    • Benowitz NL, Perez-Stable EJ, Fong I, Modin G, Herrera B, and Jacob P 3rd (1999) Ethnic differences in N-glucuronidation of nicotine and cotinine. J Pharmacol Exp Ther 291:1196-1203.
    • Benowitz NL, Perez-Stable EJ, Fong I, Modin G, Herrera B, and Jacob P 3rd (1999) Ethnic differences in N-glucuronidation of nicotine and cotinine. J Pharmacol Exp Ther 291:1196-1203.
  • 4
    • 0142247254 scopus 로고    scopus 로고
    • Benowitz NL, Pomerleau OF, Pomerleau CS, and Jacob P 3rd (2003) Nicotine metabolite ratio as a predictor of cigarette consumption. Nicotine Tob Res 5:621-624.
    • Benowitz NL, Pomerleau OF, Pomerleau CS, and Jacob P 3rd (2003) Nicotine metabolite ratio as a predictor of cigarette consumption. Nicotine Tob Res 5:621-624.
  • 6
    • 35148893148 scopus 로고    scopus 로고
    • Glucuronidation of nicotine and cotinine by UGT2B10: Loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism
    • Chen G, Blevins-Primeau AS, Dellinger RW, Muscat JE, and Lazarus P (2007) Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism. Cancer Res 67:9024-9029.
    • (2007) Cancer Res , vol.67 , pp. 9024-9029
    • Chen, G.1    Blevins-Primeau, A.S.2    Dellinger, R.W.3    Muscat, J.E.4    Lazarus, P.5
  • 7
    • 40049105052 scopus 로고    scopus 로고
    • Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines
    • Chen G, Dellinger RW, Gallagher CJ, Sun D, and Lazarus P (2008) Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. Pharmacogenet Genomics 18:181-191.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 181-191
    • Chen, G.1    Dellinger, R.W.2    Gallagher, C.J.3    Sun, D.4    Lazarus, P.5
  • 9
    • 1842532189 scopus 로고    scopus 로고
    • Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDPglucuronosyltransferase UGT1A4
    • Ehmer U, Vogel A, Schü tte JK, Krone B, Manns MP, and Strassburg CP (2004) Variation of hepatic glucuronidation: novel functional polymorphisms of the UDPglucuronosyltransferase UGT1A4. Hepatology 39:970-977.
    • (2004) Hepatology , vol.39 , pp. 970-977
    • Ehmer, U.1    Vogel, A.2    Schü tte, J.K.3    Krone, B.4    Manns, M.P.5    Strassburg, C.P.6
  • 12
    • 0030833096 scopus 로고    scopus 로고
    • Increasing urinary cotinine concentrations at elevated temperatures: The role of conjugated metabolites
    • Hagan RL, Ramos JM Jr, and Jacob PM 3rd (1997) Increasing urinary cotinine concentrations at elevated temperatures: the role of conjugated metabolites. J Pharm Biomed Anal 16:191-197.
    • (1997) J Pharm Biomed Anal , vol.16 , pp. 191-197
    • Hagan, R.L.1    Ramos Jr, J.M.2    Jacob 3rd, P.M.3
  • 14
    • 0032735407 scopus 로고    scopus 로고
    • Effects of watercress consumption on urinary metabolites of nicotine in smokers
    • Hecht SS, Carmella SG, and Murphy SE (1999a) Effects of watercress consumption on urinary metabolites of nicotine in smokers. Cancer Epidemiol Biomarkers Prev 8:907-913.
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 907-913
    • Hecht, S.S.1    Carmella, S.G.2    Murphy, S.E.3
  • 17
    • 60549102291 scopus 로고    scopus 로고
    • Smokers of menthol and nonmenthol cigarettes exhibit similar levels of biomarkers of smoke exposure
    • Heck JD (2009) Smokers of menthol and nonmenthol cigarettes exhibit similar levels of biomarkers of smoke exposure. Cancer Epidemiol Biomarkers Prev 18:622-629.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 622-629
    • Heck, J.D.1
  • 19
    • 14144253640 scopus 로고    scopus 로고
    • Metabolism and disposition kinetics of nicotine
    • Hukkanen J, Jacob P 3rd, and Benowitz NL (2005) Metabolism and disposition kinetics of nicotine. Pharmacol Rev 57:79-115.
    • (2005) Pharmacol Rev , vol.57 , pp. 79-115
    • Hukkanen, J.1    Jacob 3rd, P.2    Benowitz, N.L.3
  • 21
    • 47949097984 scopus 로고    scopus 로고
    • Regio- and stereospecific N-glucuronidation of medetomidine: The differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes
    • Kaivosaari S, Toivonen P, Aitio O, Sipilä J, Koskinen M, Salonen JS, and Finel M (2008) Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes. Drug Metab Dispos 36:1529-1537.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1529-1537
    • Kaivosaari, S.1    Toivonen, P.2    Aitio, O.3    Sipilä, J.4    Koskinen, M.5    Salonen, J.S.6    Finel, M.7
  • 23
    • 34047230804 scopus 로고    scopus 로고
    • Urine nicotine metabolites and smoking behavior in a multiracial/multiethnic national sample of young adults
    • Kandel DB, Hu MC, Schaffran C, Udry JR, and Benowitz NL (2007) Urine nicotine metabolites and smoking behavior in a multiracial/multiethnic national sample of young adults. Am J Epidemiol 165:901-910.
    • (2007) Am J Epidemiol , vol.165 , pp. 901-910
    • Kandel, D.B.1    Hu, M.C.2    Schaffran, C.3    Udry, J.R.4    Benowitz, N.L.5
  • 24
    • 0142150014 scopus 로고    scopus 로고
    • N-Glucuronidation of nicotine and cotinine by human liver microsomes and heterologously-expressed UDP-glucuronosyltransferases
    • Kuehl GE and Murphy SE (2003) N-Glucuronidation of nicotine and cotinine by human liver microsomes and heterologously-expressed UDP-glucuronosyltransferases. Drug Metab Dispos 31:1361-1368.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1361-1368
    • Kuehl, G.E.1    Murphy, S.E.2
  • 25
    • 27444436445 scopus 로고    scopus 로고
    • Genotypephenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes
    • Lazarus P, Zheng Y, Aaron Runkle E, Muscat JE, and Wiener D (2005) Genotypephenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes. Pharmacogenet Genomics 15:769-778.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 769-778
    • Lazarus, P.1    Zheng, Y.2    Aaron Runkle, E.3    Muscat, J.E.4    Wiener, D.5
  • 26
    • 33645525613 scopus 로고    scopus 로고
    • Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy
    • Malaiyandi V, Lerman C, Benowitz NL, Jepson C, Patterson F, and Tyndale RF (2006) Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy. Mol Psychiatry 11:400-409.
    • (2006) Mol Psychiatry , vol.11 , pp. 400-409
    • Malaiyandi, V.1    Lerman, C.2    Benowitz, N.L.3    Jepson, C.4    Patterson, F.5    Tyndale, R.F.6
  • 28
    • 22944440387 scopus 로고    scopus 로고
    • Nicotine 5′-oxidation and methyl oxidation by P450 2A enzymes
    • Murphy SE, Raulinaitis V, and Brown KM (2005) Nicotine 5′-oxidation and methyl oxidation by P450 2A enzymes. Drug Metab Dispos 33:1166-1173.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1166-1173
    • Murphy, S.E.1    Raulinaitis, V.2    Brown, K.M.3
  • 29
    • 42949141477 scopus 로고    scopus 로고
    • Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent
    • Mwenifumbo JC, Al Koudsi N, Ho MK, Zhou Q, Hoffmann EB, Sellers EM, and Tyndale RF (2008) Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. Hum Mutat 29:679-688.
    • (2008) Hum Mutat , vol.29 , pp. 679-688
    • Mwenifumbo, J.C.1    Al Koudsi, N.2    Ho, M.K.3    Zhou, Q.4    Hoffmann, E.B.5    Sellers, E.M.6    Tyndale, R.F.7
  • 30
    • 36448929757 scopus 로고    scopus 로고
    • Genetic variability in CYP2A6 and the pharmacokinetics of nicotine
    • Mwenifumbo JC and Tyndale RF (2007) Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. Pharmacogenomics 8:1385-1402.
    • (2007) Pharmacogenomics , vol.8 , pp. 1385-1402
    • Mwenifumbo, J.C.1    Tyndale, R.F.2
  • 31
    • 85136452666 scopus 로고    scopus 로고
    • Pérez-Stable EJ, Herrera B, Jacob P 3rd, and Benowitz NL (1998) Nicotine metabolism and intake in black and white smokers. J Am Med Assoc 280:152-156.
    • Pérez-Stable EJ, Herrera B, Jacob P 3rd, and Benowitz NL (1998) Nicotine metabolism and intake in black and white smokers. J Am Med Assoc 280:152-156.
  • 32
    • 0029988316 scopus 로고    scopus 로고
    • Exposure of the US population to environmental tobacco smoke: The Third National Health and Nutrition Examination Survey, 1988 to 1991
    • Pirkle JL, Flegal KM, Bernert JT, Brody DJ, Etzel RA, and Maurer KR (1996) Exposure of the US population to environmental tobacco smoke: the Third National Health and Nutrition Examination Survey, 1988 to 1991. J Am Med Assoc 275:1233-1240.
    • (1996) J Am Med Assoc , vol.275 , pp. 1233-1240
    • Pirkle, J.L.1    Flegal, K.M.2    Bernert, J.T.3    Brody, D.J.4    Etzel, R.A.5    Maurer, K.R.6
  • 34
    • 33846781400 scopus 로고    scopus 로고
    • Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany
    • Scherer G, Engl J, Urban M, Gilch G, Janket D, and Riedel K (2007) Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany. Regul Toxicol Pharmacol 47:171-183.
    • (2007) Regul Toxicol Pharmacol , vol.47 , pp. 171-183
    • Scherer, G.1    Engl, J.2    Urban, M.3    Gilch, G.4    Janket, D.5    Riedel, K.6
  • 35
    • 4644255903 scopus 로고    scopus 로고
    • Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
    • Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, and Tyndale RF (2004) Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics 14:615-626.
    • (2004) Pharmacogenetics , vol.14 , pp. 615-626
    • Schoedel, K.A.1    Hoffmann, E.B.2    Rao, Y.3    Sellers, E.M.4    Tyndale, R.F.5
  • 38
    • 29244464299 scopus 로고    scopus 로고
    • Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism
    • von Weymarn LB, Brown KM, and Murphy SE (2006) Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism. J Pharmacol Exp Ther 316:295-303.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 295-303
    • von Weymarn, L.B.1    Brown, K.M.2    Murphy, S.E.3
  • 39


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