메뉴 건너뛰기




Volumn 22, Issue 5, 2004, Pages 419-425

Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted

Author keywords

CYP2A6; LC MS MS; Nicotine; Poor metabolizer

Indexed keywords

COTININE; CYTOCHROME P450 2A6; DRUG METABOLITE; NICOTINE; NICOTINE GUM;

EID: 3242664997     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.04.012     Document Type: Article
Times cited : (76)

References (31)
  • 2
    • 0034805710 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism altering stability and activity of CYP2A6
    • Ariyoshi N., Sawamura Y., Kamataki T. A novel single nucleotide polymorphism altering stability and activity of CYP2A6. Biochem. Biophys. Res. Commun. 281:2001;810-814
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 810-814
    • Ariyoshi, N.1    Sawamura, Y.2    Kamataki, T.3
  • 3
    • 0036667958 scopus 로고    scopus 로고
    • Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese
    • Ariyoshi N., Sekine H., Saito K., Kamataki T. Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese. Pharmacogenetics. 12:2002;501-504
    • (2002) Pharmacogenetics , vol.12 , pp. 501-504
    • Ariyoshi, N.1    Sekine, H.2    Saito, K.3    Kamataki, T.4
  • 4
    • 0023106624 scopus 로고
    • Determinants of nicotine intake while chewing nicotine polacrilex gum
    • Benowitz N.L., Jacob P. III, Savanapridi C. Determinants of nicotine intake while chewing nicotine polacrilex gum. Clin. Pharmacol. Ther. 41:1987;467-473
    • (1987) Clin. Pharmacol. Ther. , vol.41 , pp. 467-473
    • Benowitz, N.L.1    Jacob III, P.2    Savanapridi, C.3
  • 5
    • 0024215844 scopus 로고
    • Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addiction
    • Benowitz N.L. Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addiction. N. Engl. J. Med. 319:1988;1318-1330
    • (1988) N. Engl. J. Med. , vol.319 , pp. 1318-1330
    • Benowitz, N.L.1
  • 6
    • 0027958225 scopus 로고
    • Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
    • Benowitz N.L., Fong I., Gupta S. Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J. Pharmacol. Exp. Ther. 268:1994;296-303
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , pp. 296-303
    • Benowitz, N.L.1    Fong, I.2    Gupta, S.3
  • 7
    • 0026586611 scopus 로고
    • Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3′-hydroxycotinine in smokers
    • Byrd G.D., Chang K.-M., Greene J.M., deBethizy J.D. Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3′-hydroxycotinine in smokers. Drug Metab. Dispos. 20:1992;192-197
    • (1992) Drug Metab. Dispos. , vol.20 , pp. 192-197
    • Byrd, G.D.1    Chang, K.-M.2    Greene, J.M.3    Debethizy, J.D.4
  • 10
    • 0035947589 scopus 로고    scopus 로고
    • CYP2A6*6, a novel polymorphism in cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity
    • Kitagawa K., Kunugita N., Kitagawa M., Kawamoto T. CYP2A6*6, a novel polymorphism in cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity. J. Biol. Chem. 276:2001;17830-17835
    • (2001) J. Biol. Chem. , vol.276 , pp. 17830-17835
    • Kitagawa, K.1    Kunugita, N.2    Kitagawa, M.3    Kawamoto, T.4
  • 11
    • 0142150014 scopus 로고    scopus 로고
    • N-Glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases
    • Kuehl G.E., Murphy S.E. N-Glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP- glucuronosyltransferases. Drug Metab. Dispos. 31:2003;1361-1368
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 1361-1368
    • Kuehl, G.E.1    Murphy, S.E.2
  • 14
    • 0032819109 scopus 로고    scopus 로고
    • Characterization of multiple products of cytochrome P450 2A6-catalyzed cotinine metabolism
    • Murphy S.E., Johnson L.M., Pullo D.A. Characterization of multiple products of cytochrome P450 2A6-catalyzed cotinine metabolism. Chem. Res. Toxicol. 12:1999;639-645
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 639-645
    • Murphy, S.E.1    Johnson, L.M.2    Pullo, D.A.3
  • 17
    • 0033965729 scopus 로고    scopus 로고
    • Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans
    • Nakajima M., Yamagishi S., Yamamoto H., Yamamoto T., Kuroiwa Y., Yokoi T. Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans. Clin. Pharmacol. Ther. 67:2000;57-69
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 57-69
    • Nakajima, M.1    Yamagishi, S.2    Yamamoto, H.3    Yamamoto, T.4    Kuroiwa, Y.5    Yokoi, T.6
  • 19
    • 0036891975 scopus 로고    scopus 로고
    • Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes
    • Nakajima M., Tanaka E., Kwon J.T., Yokoi T. Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes. Drug Metab. Dispos. 30:2002;1484-1490
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1484-1490
    • Nakajima, M.1    Tanaka, E.2    Kwon, J.T.3    Yokoi, T.4
  • 21
    • 0032945691 scopus 로고    scopus 로고
    • A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans
    • Nunoya K., Yokoi T., Kimura K., Kainuma T., Satoh K., Kinoshita M., Kamataki T. A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans. J. Pharmacol. Exp. Ther. 289:1999a;437-442
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 437-442
    • Nunoya, K.1    Yokoi, T.2    Kimura, K.3    Kainuma, T.4    Satoh, K.5    Kinoshita, M.6    Kamataki, T.7
  • 22
    • 0032838745 scopus 로고    scopus 로고
    • Homologous unequal cross-over within the human CYP2A gene cluster as a mechanism for the deletion of the entire CYP2A6 gene associated with the poor metaboliser phenotype
    • Nunoya K., Yokoi T., Takahashi K., Kimura K., Kinoshita M., Kamataki T. Homologous unequal cross-over within the human CYP2A gene cluster as a mechanism for the deletion of the entire CYP2A6 gene associated with the poor metaboliser phenotype. J. Biochem. 126:1999b;402-407
    • (1999) J. Biochem. , vol.126 , pp. 402-407
    • Nunoya, K.1    Yokoi, T.2    Takahashi, K.3    Kimura, K.4    Kinoshita, M.5    Kamataki, T.6
  • 26
    • 0037291512 scopus 로고    scopus 로고
    • Nicotine metabolism, human drug metabolism polymorphisms, and smoking behavior
    • Tricker A.R. Nicotine metabolism, human drug metabolism polymorphisms, and smoking behavior. Toxicology. 183:2003;151-173
    • (2003) Toxicology , vol.183 , pp. 151-173
    • Tricker, A.R.1
  • 28
    • 0025022689 scopus 로고
    • The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
    • Yamano S., Tatsuno J., Gonzalez F.J. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry. 29:1990;1322-1329
    • (1990) Biochemistry , vol.29 , pp. 1322-1329
    • Yamano, S.1    Tatsuno, J.2    Gonzalez, F.J.3
  • 29
    • 0032931833 scopus 로고    scopus 로고
    • Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
    • Yamazaki H., Inoue K., Hashimoto M., Shimada T. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch. Toxicol. 73:1999;65-70
    • (1999) Arch. Toxicol. , vol.73 , pp. 65-70
    • Yamazaki, H.1    Inoue, K.2    Hashimoto, M.3    Shimada, T.4
  • 31
    • 0037757965 scopus 로고    scopus 로고
    • Effects of polymorphism in promoter region of CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro
    • Yoshida R., Nakajima M., Nishimura K., Tokudome S., Kwon J.T., Yokoi T. Effects of polymorphism in promoter region of CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro. Clin. Pharmacol. Ther. 74:2003;69-76
    • (2003) Clin. Pharmacol. Ther. , vol.74 , pp. 69-76
    • Yoshida, R.1    Nakajima, M.2    Nishimura, K.3    Tokudome, S.4    Kwon, J.T.5    Yokoi, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.