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Volumn 32, Issue 4, 2013, Pages 403-413

Endometrial carcinoma: Molecular alterations involved in tumor development and progression

Author keywords

catenin; apoptosis; chromosomal instability; endometrial carcinoma; genetics; microsatellite instability; molecular alterations

Indexed keywords

APOPTOSIS; CANCER INVASION; CANCER PROGNOSIS; CANCER STAGING; CARCINOGENESIS; CELL HYPOXIA; CELL SURVIVAL; CHROMOSOMAL INSTABILITY; CTNNB1 GENE; ENDOMETRIUM CARCINOMA; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; IONIZING RADIATION; MICROSATELLITE INSTABILITY; MIXED MULLERIAN TUMOR; MYOMETRIUM; NUCLEOTIDE SEQUENCE; ONCOGENE K RAS; PIK3CA GENE; PRIORITY JOURNAL; PROMOTER REGION; PTEN GENE; REVIEW; SIGNAL TRANSDUCTION; TP53 GENE; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; UNINDEXED SEQUENCE;

EID: 84873059633     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.76     Document Type: Review
Times cited : (149)

References (87)
  • 1
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983; 15: 10-17.
    • (1983) Gynecol Oncol , vol.15 , pp. 10-17
    • Bokhman, J.V.1
  • 4
    • 70349140898 scopus 로고    scopus 로고
    • Molecular pathology of endometrial carcinoma; Practical aspects from the diagnostic and therapeutical view points
    • Llobet D, Pallares J, Yeramian A, Santacana M, Eritja N, Velasco A et al. Molecular pathology of endometrial carcinoma; practical aspects from the diagnostic and therapeutical view points. J Clin Pathol 2009; 62: 777-785.
    • (2009) J Clin Pathol , vol.62 , pp. 777-785
    • Llobet, D.1    Pallares, J.2    Yeramian, A.3    Santacana, M.4    Eritja, N.5    Velasco, A.6
  • 6
    • 0029122057 scopus 로고
    • Microsatellite instability in endometrial carcinomas: Frequent replication errors in tumors of early onset and/or of poorly differentiated type
    • Kobayashi K, Sagae S, Kudo H, Koi S, Nakamura Y. Microsatellite instability in endometrial carcinomas: frequent replication errors in tumors of early onset and/or of poorly differentiated type. Genes Chromosom Cancer 1995; 14: 128-132.
    • (1995) Genes Chromosom Cancer , vol.14 , pp. 128-132
    • Kobayashi, K.1    Sagae, S.2    Kudo, H.3    Koi, S.4    Nakamura, Y.5
  • 8
    • 0031690464 scopus 로고    scopus 로고
    • Microsatellite instability in endometrial carcinomas clinicopathologic correlations in a series of 42 cases
    • Catasú s L, Machin P, Matias-Guiu X, Prat J. Microsatellite instability in endometrial carcinomas clinicopathologic correlations in a series of 42 cases. Human Pathol 1998; 29: 1160-1164.
    • (1998) Human Pathol , vol.29 , pp. 1160-1164
    • Catasús, L.1    MacHin, P.2    Matias-Guiu, X.3    Prat, J.4
  • 9
  • 10
    • 0031761109 scopus 로고    scopus 로고
    • BAX somatic framshift mutations in endometrioid adenocarcinomas of the endometrium: Evidence for a tumor progression role in endometrioid carcinomas with microsatellite instability
    • Catasú s L, Matias-Guiu X, Machin P, Mun? oz J, Prat J. BAX somatic framshift mutations in endometrioid adenocarcinomas of the endometrium: Evidence for a tumor progression role in endometrioid carcinomas with microsatellite instability. Lab Invest 1998; 78: 1439-1444.
    • (1998) Lab Invest , vol.78 , pp. 1439-1444
    • Catasús, L.1    Matias-Guiu, X.2    MacHin, P.3    Munoz, J.4    Prat, J.5
  • 11
    • 0034657583 scopus 로고    scopus 로고
    • Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinomas with microsatellite instability
    • Catasú s L, Matias-Guiu X, Machin P, Zannoni GF, Scambia G, Benedetti Panici PL et al. Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinomas with microsatellite instability. Cancer 2000; 88: 2290-2297.
    • (2000) Cancer , vol.88 , pp. 2290-2297
    • Catasús, L.1    Matias-Guiu, X.2    MacHin, P.3    Zannoni, G.F.4    Scambia, G.5    Benedetti Panici, P.L.6
  • 13
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 1997; 57: 3935-3940.
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3    Cho, K.R.4    Bose, S.5    Wang, S.I.6
  • 14
    • 0034019805 scopus 로고    scopus 로고
    • PTEN mutations in endometrial carcinomas. A molecular and clinicopathologic analysis of 38 cases
    • Bussaglia E, del Rio E, Matias-Guiu X, Prat J. PTEN mutations in endometrial carcinomas. A molecular and clinicopathologic analysis of 38 cases. Hum Pathol 2000; 31: 312-317.
    • (2000) Hum Pathol , vol.31 , pp. 312-317
    • Bussaglia, E.1    Del Rio, E.2    Matias-Guiu, X.3    Prat, J.4
  • 15
    • 0030471493 scopus 로고    scopus 로고
    • Deletion mapping on chromosome 10q25-q26 in human endometrial cancer
    • Nagase S, Sato S, Tezuka F, Wada Y, Yajima A, Horii A. Deletion mapping on chromosome 10q25-q26 in human endometrial cancer. Br J Cancer 1996; 74: 1979-1983.
    • (1996) Br J Cancer , vol.74 , pp. 1979-1983
    • Nagase, S.1    Sato, S.2    Tezuka, F.3    Wada, Y.4    Yajima, A.5    Horii, A.6
  • 16
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007; 128: 157-170.
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3    Wu, H.4    Eng, C.5    Pandolfi, P.P.6
  • 18
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • Oda K, Stokoe D, Taketani Y, McCormick F. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res 2005; 65: 10669-10673.
    • (2005) Cancer Res , vol.65 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3    McCormick, F.4
  • 19
    • 33750039395 scopus 로고    scopus 로고
    • PIK3CA gene mutations in endometrial carcinoma: Correlation with PTEN and K-RAS alterations
    • Velasco A, Bussaglia E, Pallares J, Dolcet X, Llobet D, Encinas M et al. PIK3CA gene mutations in endometrial carcinoma: Correlation with PTEN and K-RAS alterations. Hum Pathol 2006; 37: 1465-1472.
    • (2006) Hum Pathol , vol.37 , pp. 1465-1472
    • Velasco, A.1    Bussaglia, E.2    Pallares, J.3    Dolcet, X.4    Llobet, D.5    Encinas, M.6
  • 20
    • 38649090091 scopus 로고    scopus 로고
    • Catasú s L, Gallardo A, Cuatrecasas M, Prat J.
    • Catasú s L, Gallardo A, Cuatrecasas M, Prat J. PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters. Mod Pathol 2008; 21: 131-139.
    • (2008) Mod Pathol , vol.21 , pp. 131-139
  • 21
    • 79952713255 scopus 로고    scopus 로고
    • A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas
    • Rudd ML, Price JC, Fogoros S, Godwin AK, Sgroi DC, Merino MJ et al. A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas. Clin Cancer Res 2011; 17: 1331-1340.
    • (2011) Clin Cancer Res , vol.17 , pp. 1331-1340
    • Rudd, M.L.1    Price, J.C.2    Fogoros, S.3    Godwin, A.K.4    Sgroi, D.C.5    Merino, M.J.6
  • 22
    • 63949083916 scopus 로고    scopus 로고
    • Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis
    • Catasú s L, Gallardo A, Cuatrecasas M, Prat J. Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis. Mod Pathol 2009; 22: 522-529.
    • (2009) Mod Pathol , vol.22 , pp. 522-529
    • Catasús, L.1    Gallardo, A.2    Cuatrecasas, M.3    Prat, J.4
  • 23
    • 67349170390 scopus 로고    scopus 로고
    • Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma
    • Hayes MP, Douglas W, Ellenson LH. Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma. Gynecol Oncol 2009; 113: 370-373.
    • (2009) Gynecol Oncol , vol.113 , pp. 370-373
    • Hayes, M.P.1    Douglas, W.2    Ellenson, L.H.3
  • 24
    • 77952009540 scopus 로고    scopus 로고
    • Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations
    • Catasú s L, D'Angelo E, Pons C, Espinosa I, Prat J. Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations. Mod Pathol 2010; 23: 694-702.
    • (2010) Mod Pathol , vol.23 , pp. 694-702
    • Catasús, L.1    D'Angelo, E.2    Pons, C.3    Espinosa, I.4    Prat, J.5
  • 25
    • 79958820962 scopus 로고    scopus 로고
    • Bell DW PIK3R1 (p85a) is somatically mutated at high frequency in primary endometrial cancer
    • Urick ME, Rudd ML, Godwin AK, Sgroi D, Merino M. Bell DW PIK3R1 (p85a) is somatically mutated at high frequency in primary endometrial cancer. Cancer Res 2011; 71: 4061-4067.
    • (2011) Cancer Res , vol.71 , pp. 4061-4067
    • Urick, M.E.1    Rudd, M.L.2    Godwin, A.K.3    Sgroi, D.4    Merino, M.5
  • 26
    • 33847415365 scopus 로고    scopus 로고
    • Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model
    • Milam MR, Celestino J, Wu W, Broaddus RR, Schmeler KM, Slomovitz BM et al. Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model. Am J Obstet Gynecol 2007; 196: 247.e1-5.
    • (2007) Am J Obstet Gynecol , vol.196
    • Milam, M.R.1    Celestino, J.2    Wu, W.3    Broaddus, R.R.4    Schmeler, K.M.5    Slomovitz, B.M.6
  • 27
    • 51849111524 scopus 로고    scopus 로고
    • NVPBEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra V, Markman B, Scaltriti M, Eichhorn PJ, Valero V, Guzman M et al. NVPBEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008; 68: 8022-8030.
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3    Eichhorn, P.J.4    Valero, V.5    Guzman, M.6
  • 28
    • 0035150494 scopus 로고    scopus 로고
    • K-ras mutations in endometrial carcinoma with microsatellite instabilit
    • Lagarda H, Catasú s L, Argu? elles R, Matias-Guiu X, Prat J. K-ras mutations in endometrial carcinoma with microsatellite instabilit. J Pathol 2001; 193: 193-199.
    • (2001) J Pathol , vol.193 , pp. 193-199
    • Lagarda, H.1    Catasús, L.2    Argu Elles, R.3    Matias-Guiu, X.4    Prat, J.5
  • 30
    • 44349169410 scopus 로고    scopus 로고
    • Hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma
    • Pallaré s J, Velasco A, Eritja N, Santacana M, Dolcet X, Cuatrecasas M et al. hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma. Mod Pathol 2008; 21: 691-699.
    • (2008) Mod Pathol , vol.21 , pp. 691-699
    • Pallarés, J.1    Velasco, A.2    Eritja, N.3    Santacana, M.4    Dolcet, X.5    Cuatrecasas, M.6
  • 32
    • 34250829395 scopus 로고    scopus 로고
    • Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    • Pollock PM, Gartside MG, Dejeza LC, Powell MA, Mallon MA, Mohammadi M et al. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 2007; 26: 7158-7162.
    • (2007) Oncogene , vol.26 , pp. 7158-7162
    • Pollock, P.M.1    Gartside, M.G.2    Dejeza, L.C.3    Powell, M.A.4    Mallon, M.A.5    Mohammadi, M.6
  • 38
    • 84871140241 scopus 로고    scopus 로고
    • Beta and gamma-catenin expression in endometrial carcinoma Relationship with clinicopathological features and microsatellite instability
    • Palacios J, Moreno-Bueno G, Catasú s L, Matias-Guiu X, Prat J, Gamallo C. Beta and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability. Virchows Arch 2001; 193: 193-199.
    • (2001) Virchows Arch , vol.193 , pp. 193-199
    • Palacios, J.1    Moreno-Bueno, G.2    Catasús, L.3    Matias-Guiu, X.4    Prat, J.5    Gamallo, C.6
  • 40
    • 0031012928 scopus 로고    scopus 로고
    • P53 gene mutations are common in uterine serous carcinoma and occurs early in their pathogenesis
    • Tashiro H, Isacson C, Levine R, Kurman RJ, Cho KR, Hedrick L. P53 gene mutations are common in uterine serous carcinoma and occurs early in their pathogenesis. Am J Pathol 1997; 150: 177-185.
    • (1997) Am J Pathol , vol.150 , pp. 177-185
    • Tashiro, H.1    Isacson, C.2    Levine, R.3    Kurman, R.J.4    Cho, K.R.5    Hedrick, L.6
  • 41
    • 0028887101 scopus 로고
    • P53 in endometrial cancer and its putative precursors: Evidence for diverse pathways of tumorigenesis
    • Sherman ME, Bur ME, Kurman RJ. P53 in endometrial cancer and its putative precursors: Evidence for diverse pathways of tumorigenesis. Human Pathol 1995; 26: 1268-1274.
    • (1995) Human Pathol , vol.26 , pp. 1268-1274
    • Sherman, M.E.1    Bur, M.E.2    Kurman, R.J.3
  • 42
    • 73949116980 scopus 로고    scopus 로고
    • Molecular alterations in uterine serous carcinoma
    • Hayes MP, Ellenson LH. Molecular alterations in uterine serous carcinoma. Gynecol Oncol 2010; 116: 286-289.
    • (2010) Gynecol Oncol , vol.116 , pp. 286-289
    • Hayes, M.P.1    Ellenson, L.H.2
  • 43
    • 33744828734 scopus 로고    scopus 로고
    • HER-2 is an independent prognostic factor in endometrial cancer: Association with outcome in a large cohort of surgically staged patients
    • Morrison C, Zanagnolo V, Ramirez N, Cohn DE, Kelbick N, Copeland L et al. HER-2 is an independent prognostic factor in endometrial cancer: Association with outcome in a large cohort of surgically staged patients. J Clin Oncol 2006; 24: 2376-2385.
    • (2006) J Clin Oncol , vol.24 , pp. 2376-2385
    • Morrison, C.1    Zanagnolo, V.2    Ramirez, N.3    Cohn, D.E.4    Kelbick, N.5    Copeland, L.6
  • 44
    • 0030958307 scopus 로고    scopus 로고
    • Loss of heterozygosity in usual and special variant carcinomas of the endometrium
    • Tritz D, Pieretti M, Turner S, Powell D. Loss of heterozygosity in usual and special variant carcinomas of the endometrium. Hum Pathol 1997; 28: 607-612.
    • (1997) Hum Pathol , vol.28 , pp. 607-612
    • Tritz, D.1    Pieretti, M.2    Turner, S.3    Powell, D.4
  • 45
    • 0034651530 scopus 로고    scopus 로고
    • Frequency of p53 K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: Evidence of distinct molecular genetic pathways
    • Lax SF, Kendall B, Tashiro H, Slebos RJ, Hedrick L. Frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: Evidence of distinct molecular genetic pathways. Cancer 2000; 88: 814-824.
    • (2000) Cancer , vol.88 , pp. 814-824
    • Lax, S.F.1    Kendall, B.2    Tashiro, H.3    Slebos, R.J.4    Hedrick, L.5
  • 46
    • 79953797962 scopus 로고    scopus 로고
    • Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma
    • Guan B, Mao TL, Panuganti PK, Kuhn E, Kurman RJ, Maeda D et al. Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. Am J Surg Pathol 2011; 35: 625-632.
    • (2011) Am J Surg Pathol , vol.35 , pp. 625-632
    • Guan, B.1    Mao, T.L.2    Panuganti, P.K.3    Kuhn, E.4    Kurman, R.J.5    Maeda, D.6
  • 48
    • 0037226389 scopus 로고    scopus 로고
    • Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer
    • Risinger JI, Maxwell GL, Chandramouli GV, Jazaeri A, Aprelikova O, Patterson T et al. Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer. Cancer Res 2003; 63: 6-11.
    • (2003) Cancer Res , vol.63 , pp. 6-11
    • Risinger, J.I.1    Maxwell, G.L.2    Chandramouli, G.V.3    Jazaeri, A.4    Aprelikova, O.5    Patterson, T.6
  • 49
    • 50249175156 scopus 로고    scopus 로고
    • Trefoil factor 3: A novel serum marker identified by gene expression profiling in high-grade endometrial carcinomas
    • Bignotti E, Ravaggi A, Tassi RA, Calza S, Rossi E, Falchetti M et al. Trefoil factor 3: A novel serum marker identified by gene expression profiling in high-grade endometrial carcinomas. Brit J Cancer 2008; 99: 768-773.
    • (2008) Brit J Cancer , vol.99 , pp. 768-773
    • Bignotti, E.1    Ravaggi, A.2    Tassi, R.A.3    Calza, S.4    Rossi, E.5    Falchetti, M.6
  • 50
    • 34248384824 scopus 로고    scopus 로고
    • Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma
    • Dainty LA, Risinger JI, Morrison C, Chandramouli GV, Bidus MA, Zahn C et al. Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma. Gynecol Oncol 2007; 105: 563-567.
    • (2007) Gynecol Oncol , vol.105 , pp. 563-567
    • Dainty, L.A.1    Risinger, J.I.2    Morrison, C.3    Chandramouli, G.V.4    Bidus, M.A.5    Zahn, C.6
  • 51
    • 34648832104 scopus 로고    scopus 로고
    • Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas
    • Allard JE, Risinger JI, Morrison C, Young G, Rose GS, Fowler J et al. Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas. Gynecol Oncol 2007; 107: 52-57.
    • (2007) Gynecol Oncol , vol.107 , pp. 52-57
    • Allard, J.E.1    Risinger, J.I.2    Morrison, C.3    Young, G.4    Rose, G.S.5    Fowler, J.6
  • 52
    • 0141619357 scopus 로고    scopus 로고
    • Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas
    • Moreno-Bueno G, Sa'nchez-Este'vez C, Cassia R, Rodri'guez-Perales S, Di'az-Uriarte R, Domi'nguez O et al. Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Cancer Res 2003; 63: 5697-5702.
    • (2003) Cancer Res , vol.63 , pp. 5697-5702
    • Moreno-Bueno, G.1    Sa'Nchez-Este'Vez, C.2    Cassia, R.3    Rodri'guez-Perales, S.4    Di'Az-Uriarte, R.5    Domi'Nguez, O.6
  • 53
    • 20344383528 scopus 로고    scopus 로고
    • Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer
    • Maxwell GL, Chandramouli GV, Dainty L, Litzi TJ, Berchuck A, Barrett JC et al. Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer. Clin Cancer Res 2005; 11: 4056-4066.
    • (2005) Clin Cancer Res , vol.11 , pp. 4056-4066
    • Maxwell, G.L.1    Chandramouli, G.V.2    Dainty, L.3    Litzi, T.J.4    Berchuck, A.5    Barrett, J.C.6
  • 54
    • 4644222599 scopus 로고    scopus 로고
    • Distinctive gene expression profiles by cDNA microarrays in endometrioid and serous carcinomas of the endometrium
    • Cao QJ, Belbin T, Socci N, Balan R, Prystowsky MB, Childs G et al. Distinctive gene expression profiles by cDNA microarrays in endometrioid and serous carcinomas of the endometrium. Int J Gynecol Pathol 2004; 23: 321-329.
    • (2004) Int J Gynecol Pathol , vol.23 , pp. 321-329
    • Cao, Q.J.1    Belbin, T.2    Socci, N.3    Balan, R.4    Prystowsky, M.B.5    Childs, G.6
  • 55
    • 20144387395 scopus 로고    scopus 로고
    • Type, organ of origin, and Wnt pathway status: Effect on gene expression in ovarian and uterine carcinomas
    • Shedden KA, Kshirsagar MP, Schwartz DR, Wu R, Yu H, Misek DE et al. type, organ of origin, and Wnt pathway status: Effect on gene expression in ovarian and uterine carcinomas. Clin Cancer Res 2005; 11: 2123-2131.
    • (2005) Clin Cancer Res , vol.11 , pp. 2123-2131
    • Shedden, K.A.1    Kshirsagar, M.P.2    Schwartz, D.R.3    Wu, R.4    Yu, H.5    Misek, D.E.6
  • 56
    • 79955917320 scopus 로고    scopus 로고
    • CDNA microarray analysis and immunohistochemistry reveal a distinct molecular phenotype in serous endometrial cancer compared to endometrioid endometrial cancer
    • Chen Y, Yao Y, Zhang L, Li X, Wang Y, Zhao L et al. cDNA microarray analysis and immunohistochemistry reveal a distinct molecular phenotype in serous endometrial cancer compared to endometrioid endometrial cancer. Exp Mol Pathol 2011; 91: 373-384.
    • (2011) Exp Mol Pathol , vol.91 , pp. 373-384
    • Chen, Y.1    Yao, Y.2    Zhang, L.3    Li, X.4    Wang, Y.5    Zhao, L.6
  • 57
    • 20444447557 scopus 로고    scopus 로고
    • Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling
    • Risinger JI, Maxwell GL, Chandramouli GV, Aprelikova O, Litzi T, Umar A et al. Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling. Cancer Res 2005; 65: 5031-5037.
    • (2005) Cancer Res , vol.65 , pp. 5031-5037
    • Risinger, J.I.1    Maxwell, G.L.2    Chandramouli, G.V.3    Aprelikova, O.4    Litzi, T.5    Umar, A.6
  • 58
    • 77955422624 scopus 로고    scopus 로고
    • Molecular classification of human endometrial cancer based on gene expression profiles from specialized microarrays
    • Yao Y, Chen Y, Wang Y, Li X, Wang J, Shen D et al. Molecular classification of human endometrial cancer based on gene expression profiles from specialized microarrays. Int J Gynaecol Obstet 2010; 110: 125-129.
    • (2010) Int J Gynaecol Obstet , vol.110 , pp. 125-129
    • Yao, Y.1    Chen, Y.2    Wang, Y.3    Li, X.4    Wang, J.5    Shen, D.6
  • 59
    • 73449088057 scopus 로고    scopus 로고
    • Gene expression profiling of endometrial adenocarcinomas reveals increased apolipoprotein e expression in poorly differentiated tumors
    • Huvila J, Brandt A, Rojas CR, Pasanen S, Talve L, Hirsima? ki P et al. Gene expression profiling of endometrial adenocarcinomas reveals increased apolipoprotein E expression in poorly differentiated tumors. Int J Gynecol Cancer 2009; 19: 1226-1231.
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 1226-1231
    • Huvila, J.1    Brandt, A.2    Rojas, C.R.3    Pasanen, S.4    Talve, L.5    Hirsimaki, P.6
  • 60
    • 10844236511 scopus 로고    scopus 로고
    • A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma
    • Planaguma J, Di'az-Fuertes M, Gil-Moreno A, Abal M, Monge M, Garci'a A et al. A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma. Cancer Res 2004; 64: 8846-8853.
    • (2004) Cancer Res , vol.64 , pp. 8846-8853
    • Planaguma, J.1    Di'Az-Fuertes, M.2    Gil-Moreno, A.3    Abal, M.4    Monge, M.5    Garci'A, A.6
  • 61
    • 78650159021 scopus 로고    scopus 로고
    • Endometrial carcinomas with ambiguous features
    • Soslow RA. Endometrial carcinomas with ambiguous features. Semin Diagn Pathol 2010; 27: 261-273.
    • (2010) Semin Diagn Pathol , vol.27 , pp. 261-273
    • Soslow, R.A.1
  • 62
    • 77953158268 scopus 로고    scopus 로고
    • Endometrial and ovarian carcinomas with undifferentiated components: Clinically aggressive and frequently underrecognized neoplasms
    • Tafe LJ, Garg K, Chew I, Tornos C, Soslow RA. Endometrial and ovarian carcinomas with undifferentiated components: Clinically aggressive and frequently underrecognized neoplasms. Mod Pathol 2010; 23: 781-789.
    • (2010) Mod Pathol , vol.23 , pp. 781-789
    • Tafe, L.J.1    Garg, K.2    Chew, I.3    Tornos, C.4    Soslow, R.A.5
  • 63
    • 0036854296 scopus 로고    scopus 로고
    • Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas
    • McCluggage WG. Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas. Int J Gynecol Cancer 2002; 12: 687-690.
    • (2002) Int J Gynecol Cancer , vol.12 , pp. 687-690
    • McCluggage, W.G.1
  • 64
    • 78650215830 scopus 로고    scopus 로고
    • Pathologic and molecular features of uterine carcinosarcomas
    • Lopez-Garcia MA, Palacios J. Pathologic and molecular features of uterine carcinosarcomas. Semin Diagn Pathol 2010; 27: 274-286.
    • (2010) Semin Diagn Pathol , vol.27 , pp. 274-286
    • Lopez-Garcia, M.A.1    Palacios, J.2
  • 68
    • 36649011436 scopus 로고    scopus 로고
    • The e-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas
    • Blechschmidt K, Kremmer E, Hollweck R, Mylonas I, Ho? fler H, Kremer M et al. The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas. Diagn Mol Pathol 2007; 16: 222-228.
    • (2007) Diagn Mol Pathol , vol.16 , pp. 222-228
    • Blechschmidt, K.1    Kremmer, E.2    Hollweck, R.3    Mylonas, I.4    Hofler, H.5    Kremer, M.6
  • 69
    • 84859893351 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma
    • Montserrat N, Mozos A, Llobet D, Dolcet X, Pons C, de Herreros AG et al. Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma. Hum Pathol 2012; 43: 632-643.
    • (2012) Hum Pathol , vol.43 , pp. 632-643
    • Montserrat, N.1    Mozos, A.2    Llobet, D.3    Dolcet, X.4    Pons, C.5    De Herreros, A.G.6
  • 70
    • 84856328897 scopus 로고    scopus 로고
    • ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells
    • Llaurado M, Abal M, Castellvi J, Cabrera S, Gil-Moreno A, Perez-Benavente A et al. ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells. Int J Cancer 2011; 130: 1532-1543.
    • (2011) Int J Cancer , vol.130 , pp. 1532-1543
    • Llaurado, M.1    Abal, M.2    Castellvi, J.3    Cabrera, S.4    Gil-Moreno, A.5    Perez-Benavente, A.6
  • 71
    • 34547103763 scopus 로고    scopus 로고
    • ERM/ETV5 up-regulation plays a role during myometrial infiltration through matrix metalloproteinase-2 activation in endometrial cancer
    • Monge M, Colas E, Doll A, Gonzalez M, Gil-Moreno A, Planaguma J et al. ERM/ETV5 up-regulation plays a role during myometrial infiltration through matrix metalloproteinase-2 activation in endometrial cancer. Cancer Res 2007; 67: 6753-6759.
    • (2007) Cancer Res , vol.67 , pp. 6753-6759
    • Monge, M.1    Colas, E.2    Doll, A.3    Gonzalez, M.4    Gil-Moreno, A.5    Planaguma, J.6
  • 72
    • 78650026900 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma
    • Planaguma J, Liljestrom M, Alameda F, Butzow R, Virtanen I, Reventos J et al. Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma. Hum Pathol 2011; 42: 57-67.
    • (2011) Hum Pathol , vol.42 , pp. 57-67
    • Planaguma, J.1    Liljestrom, M.2    Alameda, F.3    Butzow, R.4    Virtanen, I.5    Reventos, J.6
  • 73
    • 78049527432 scopus 로고    scopus 로고
    • Myometrial invasion and lymph node metastasis in endometrioid carcinomas: Tumor-associated macrophages, microvessel density, and HIF1A have a crucial role
    • Espinosa I, Carnicer MJ, Catasú s L, Canet B, D'Angelo E, Zannoni GF et al. Myometrial invasion and lymph node metastasis in endometrioid carcinomas: Tumor-associated macrophages, microvessel density, and HIF1A have a crucial role. Am J Surg Pathol 2010; 34: 1708-1714.
    • (2010) Am J Surg Pathol , vol.34 , pp. 1708-1714
    • Espinosa, I.1    Carnicer, M.J.2    Catasús, L.3    Canet, B.4    D'Angelo, E.5    Zannoni, G.F.6
  • 75
    • 9744257018 scopus 로고    scopus 로고
    • Abnormalities in NF-kB family and related proteins in endometrial carcinoma. A tissue microarray study
    • Pallares J, Martinez-Guitarte JL, Dolcet X, Llobet D, Rue M, Palacios J et al. Abnormalities in NF-kB family and related proteins in endometrial carcinoma. A tissue microarray study. J Pathol 2004; 13: 569-577.
    • (2004) J Pathol , vol.13 , pp. 569-577
    • Pallares, J.1    Martinez-Guitarte, J.L.2    Dolcet, X.3    Llobet, D.4    Rue, M.5    Palacios, J.6
  • 76
    • 22544479422 scopus 로고    scopus 로고
    • FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis
    • Dolcet X, Llobet D, Pallares J, Rue M, Comella JX, Matias-Guiu X. FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis. Lab Invest 2005; 85: 885-894.
    • (2005) Lab Invest , vol.85 , pp. 885-894
    • Dolcet, X.1    Llobet, D.2    Pallares, J.3    Rue, M.4    Comella, J.X.5    Matias-Guiu, X.6
  • 77
    • 79953672942 scopus 로고    scopus 로고
    • Dolcet KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels
    • Llobet D, Eritja N, Domingo M, Bergada L, Mirantes C, Santacana M et al. Dolcet KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels. Am J Pathol 2011; 178: 1529-1543.
    • (2011) Am J Pathol , vol.178 , pp. 1529-1543
    • Llobet, D.1    Eritja, N.2    Domingo, M.3    Bergada, L.4    Mirantes, C.5    Santacana, M.6
  • 78
    • 76249092117 scopus 로고    scopus 로고
    • The multikinase inhibitor sorafenib induces apoptosis and sensitizes endometrial cancer cells to TRAIL by different mechanisms
    • Llobet D, Eritja N, Encinas M, Yeramian A, Pallares J, Sorolla A et al. The multikinase inhibitor sorafenib induces apoptosis and sensitizes endometrial cancer cells to TRAIL by different mechanisms. Eur J Cancer 2010; 46: 836-850.
    • (2010) Eur J Cancer , vol.46 , pp. 836-850
    • Llobet, D.1    Eritja, N.2    Encinas, M.3    Yeramian, A.4    Pallares, J.5    Sorolla, A.6
  • 79
    • 42249090023 scopus 로고    scopus 로고
    • CK2 controls trail and Fas sensitivity by regulating flip levels in endometrial carcinoma cells
    • Llobet D, Eritja N, Encinas M, Yeramian A, Pallares J, Sorolla A et al. CK2 controls trail and Fas sensitivity by regulating flip levels in endometrial carcinoma cells. Oncogene 2008; 27: 2513-2524.
    • (2008) Oncogene , vol.27 , pp. 2513-2524
    • Llobet, D.1    Eritja, N.2    Encinas, M.3    Yeramian, A.4    Pallares, J.5    Sorolla, A.6
  • 80
    • 58249107825 scopus 로고    scopus 로고
    • CK2beta is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation
    • Pallares J, Llobet D, Santacana M, Eritja N, Velasco A, Cuevas D et al. CK2beta is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation. Am J Pathol 2009; 174: 287-296.
    • (2009) Am J Pathol , vol.174 , pp. 287-296
    • Pallares, J.1    Llobet, D.2    Santacana, M.3    Eritja, N.4    Velasco, A.5    Cuevas, D.6
  • 81
    • 33746840548 scopus 로고    scopus 로고
    • Proteasome inhibitors induce death but activate NF-KB on endometrial carcinoma cell lines and primary culture explants
    • Dolcet X, Llobet D, Encinas M, Pallares J, Cabero A, Schoenenberger JA et al. Proteasome inhibitors induce death but activate NF-KB on endometrial carcinoma cell lines and primary culture explants. J Biol Chem 2006; 281: 22118-22130.
    • (2006) J Biol Chem , vol.281 , pp. 22118-22130
    • Dolcet, X.1    Llobet, D.2    Encinas, M.3    Pallares, J.4    Cabero, A.5    Schoenenberger, J.A.6
  • 86
    • 84856252570 scopus 로고    scopus 로고
    • Immunohistochemical features of post-radiation vaginal recurrences of endometrioid carcinomas of the endometrium Role for proteins involved in resistance to apoptosis and hypoxia
    • Santacana M, Yeramian A, Velasco A, Bergada L, Garci'a V, Azueta A et al. Immunohistochemical features of post-radiation vaginal recurrences of endometrioid carcinomas of the endometrium. Role for proteins involved in resistance to apoptosis and hypoxia. Histopathology 2012; 60: 460-471.
    • (2012) Histopathology , vol.60 , pp. 460-471
    • Santacana, M.1    Yeramian, A.2    Velasco, A.3    Bergada, L.4    Garci'A, V.5    Azueta, A.6
  • 87
    • 79957593648 scopus 로고    scopus 로고
    • Nuclear factor beta /p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1alpha in an independent manner
    • Yeramian A, Santacana M, Sorolla A, Llobet D, Encinas M, Velasco A et al. Nuclear factor beta /p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1alpha in an independent manner. Lab Invest 2011; 91: 859-871.
    • (2011) Lab Invest , vol.91 , pp. 859-871
    • Yeramian, A.1    Santacana, M.2    Sorolla, A.3    Llobet, D.4    Encinas, M.5    Velasco, A.6


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