Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas

Cancer Research

Volumn 63, Issue 18, 2003, Pages 5697-5702

  Moreno Bueno, Gema ^a   Sánchez Estévez, Carolina ^a   Cassia, Raúl ^a   Rodríguez Perales, Sandra ^a   Díaz Uriarte, Ramón ^a   Domínguez, Orlando ^a   Hardisson, David ^b   Andujar, Miguel ^c   Prat, Jaime ^d   Matias Guiu, Xavier ^e   Cigudosa, Juan C ^a   Palacios, José ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c HOSPITAL UNIVERSITARIO MATERNO INFANTIL DE CANARIAS   (Spain)

^d Hospital Sant Pau I Santa Creu   (Spain)

^e Hospital Arnau de Villanova   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN;

ANEUPLOIDY; ARTICLE; BREAST CANCER; BUB1 GENE; CANCER CLASSIFICATION; CARCINOGENESIS; CCNB2 GENE; CLINICAL ARTICLE; DNA MICROARRAY; END1 GENE; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CARCINOMA; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HISTOLOGY; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; LTF GENE; MENSTRUAL CYCLE; MGB2 GENE; MITOSIS SPINDLE; MMP11 GENE; NUCLEOTIDE SEQUENCE; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; STK15 GENE; UNINDEXED SEQUENCE;

CARCINOMA, ENDOMETRIOID; ENDOMETRIAL NEOPLASMS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN-SERINE-THREONINE KINASES;

EID: 0141619357     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Evans, D. G. R. Genetics of gynaecological cancer. Curr. Obstet. Gynaecol., 5: 201-205, 1995.
2. Matias-Guiu, X., Catasus, L., Bussaglia, E., Lagarda, H., Garcia, A., Pons, C., Munoz, J., Arguelles, R., Machin, P., and Prat, J. Molecular pathology of endometrial hyperplasia and carcinoma. Hum. Pathol., 32: 569-577, 2001.
3. Kao, L. C., Tulac, S., Lobo, S., Imani, B., Yang, J. P., Germeyer, A., Osteen, K., Taylor, R. N., Lessey, B. A., and Giudice, L. C. Global gene profiling in human endometrium during the window of implantation. Endocrinology, 143: 2119-2138, 2002.
4. Risinger, J. I., Maxwell, G. L., Chandramouli, G. V., Jazaeri, A., Aprelikova, O., Patterson, T., Berchuck, A., and Barrett, J. C. Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer. Cancer Res., 63: 6-11, 2003.
5. Machin, P., Catasus, L., Pons, C., Muñoz, J., Matias-Guiu, X., and Prat, J. CTNNB1 mutations and β-catenin expression in endometrial carcinomas. Hum. Pathol., 33: 206-212, 2002.
6. Ono, K., Tanaka, T., Tsunoda, T., Kitahara, O., Kihara, C., Okamoto, A., Ochiai, K., and Takagi, T. Identification by cDNA microarray of genes involved in ovarain carcinogenesis. Cancer Res., 60: 5007-5011, 2000.
7. Tracey, L., Villuendas, R., Ortiz, P., Dopazo, A., Spiteri, I., Lombardia, L., Rodriguez-Peralto, J. L., Fernandez-Herrera. J., Hernandez, A., Fraga, J., Dominguez, O., Herrero, J., Alonso, M. A., Dopazo, J., and Piris, M. A. Identification of genes involved in resistance to interferon-α in cutaneous T-cell lymphoma. Am. J. Pathol., 161: 1825-1837, 2002.
8. Miller, R. G., Jr. Beyond ANOVA: Basics of Applied Statistics. New York: Chapman & Hall, 1997.
9. Westfall, P. H., and Young, S. S. Resampling-based Multiple Testing: Examples and Methods for P-Value Adjustment. New York: John Wiley & Sons, 1993.
10. Dudoit, S., Yang, Y. H., Callow, M. J., and Speed, T. P. Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments. Stat. Sin., 12: 111-139, 2002.
11. Kononen, J., Bubendorf, L., Kallioniemi, A., Barlund, M., Schraml, P., Leighton, S., Torhorst, J., Mihatsch, M. J., Sauter, G., and Kallioniemi, O. P. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med., 4: 767-768, 1998.
12. Milliken, G. A., and Johnsons, D. E. Analysis of Messy Data, Vol. 1. Designed Experiments. New York: Chapman & Hall, 1992.
13. Yandell, B. S. Practical Data Analysis for Designed Experiments. New York: Chapman & Hall, 1997.
14. Muller-Schottle, F., Classen-Linke, I., Beier-Hellwig, K., Sterzik, K., and Beier, H. M. Uteroglobin expression and release in the human endometrium. Ann. N. Y. Acad. Sci., 923: 332-335, 2000.
15. Becker, R. M., Darrow, C., Zimonjic, D. B., Popescu, N. C., Watson, M. A., and Fleming, T. P. Identification of mammaglobin B, a novel member of the uteroglobin gene family. Genomics, 54: 70-78, 1998.
16. Aihara, T., Fujiwara, Y., Miyake, Y., Okami, J., Okada, Y., Iwao, K., Sugita, Y., Tomita, N., Sakon, M., Shiozaki, H., and Monden, M. Mammaglobin B gene as a novel marker for lymph node micrometastasis in patients with abdominal cancers. Cancer Lett., 150: 79-84, 2000.
17. Walmer, D. K., Wrona, M. A., Hughes, C. L., and Nelson, K. G. Lactoferrin expression in the mouse reproductive tract during the natural estrogenous cycle: correlation with circulating estradiol and progesterone. Endocrinology, 131: 1458-1466, 1992.
18. Albright, C. D., and Kaufman, D. G. Lactoferrin: a tamoxifen-responsive protein in normal and malignant human endometrial cells in culture. Exp. Mol. Pathol., 70: 71-76, 2001.
19. Economos, K., MacDonald, P. C., and Casey, M. L. Endothelin-1 gene expression and biosynthesis in human endometrial HEC-1A cancer cells. Cancer Res., 52: 554-557, 1992.
20. Klinge, C. M. Estrogen receptor interaction with co-activators and co-repressors. Steroids, 65: 227-251, 2000.
21. Girault, I., Lerebours, F., Amarir, S., Tozlu, S., Tubiana-Hulin, M., Lidereau, R., and Bieche, I. Expression analysis of estrogen receptor α coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen. Clin. Cancer Res., 9: 1259-1266, 2003.
22. Katayama, H., Zhou, H., Li, Q., Tatsuka, M., and Sen, S. Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J. Biol. Chem., 276: 46219-46224. 2001.
23. Zhou, H., Kuang, J., Zhong, L., Kuo. W. L., Gray, J. W., Sahin, A., Brinkley, B. R., and Sen, S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet., 20: 104-106, 1998.
24. Anand, S., Penrhyn-Lowe, S., and Venkitaraman, A. R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint. Inducing resistance to Taxol. Cancer Cell, 3: 51-62, 2003.
25. Miyoshi, Y., Iwao, K., Egawa, C., and Noguchi, S. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosoma instability in human breast cancers. Int. J. Cancer, 92: 370-373, 2001.
26. Gritsko, T. M., Coppola, D., Paciga, J. E., Yang, L., Sun, M., Shelley, S. A., Fiorica, J. V., Nicosia, S. V., and Cheng, J. Q. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin. Cancer Res., 9: 1420-1426, 2003.
27. Albor, A., Kaku, S., and Kulesz-Martin, M. Wild-type and mutant forms of p53 activate human topoisomerase 1: a possible mechanism for gain of function in mutants. Cancer Res., 58: 2091-2094, 1998.
28. Cassia, R., Moreno-Bueno, G., Rodríguez-Perales, S., Hardisson, D., Cigudosa, J. C., and Palacios, J. Cyclin E gene (CCNE) amplificaticn and hCDC4 mutations in endometrial carcinoma. J. Pathol., in press, 2003.