Gene expression profiling of endometrial adenocarcinomas reveals increased apolipoprotein e expression in poorly differentiated tumors

International Journal of Gynecological Cancer

Volumn 19, Issue 7, 2009, Pages 1226-1231

  Huvila, Jutta ^a   Brandt, Annika ^b   Rojas, Clarissa Rios ^b   Pasanen, Salla ^b   Talve, Lauri ^a   Hirsimäki, Pirkko ^a   Fey, Vidal ^b   Kytömäki, Leena ^b   Saukko, Pekka ^c   Carpén, Olli ^a   Soini, Juhani T ^b,d   Grénman, Seija ^a   Auranen, Annika ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b TURKU CENTRE FOR BIOTECHNOLOGY   (Finland)

^c TURKU UNIVERSITY   (Finland)

^d TURKU UNIVERSITY OF APPLIED SCIENCES   (Finland)

Author keywords

Apolipoprotein E; Differentiation; Endometrial cancer; Gene expression

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ARTICLE; CDC42BPB GENE; CLINICAL ARTICLE; CONTROLLED STUDY; DDX59 GENE; ENDOMETRIUM CARCINOMA; FEMALE; FLJ13848 GENE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; IFI30 GENE; NISCH GENE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TORC2 GENE; UBXD4 GENE; UPREGULATION; ADENOCARCINOMA; CANCER STAGING; CELL DIFFERENTIATION; COMPARATIVE STUDY; DISEASE COURSE; DNA MICROARRAY; ENDOMETRIOID CARCINOMA; ENDOMETRIUM TUMOR; GENETICS; INSTRUMENTATION; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; APOLIPOPROTEINS E; CARCINOMA, ENDOMETRIOID; CELL DIFFERENTIATION; DISEASE PROGRESSION; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; NEOPLASM STAGING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 73449088057     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1111/IGC.0b013e3181b33be0     Document Type: Article

References (20)

1. Amant F, Moerman P, Neven P, et al. Endometrial cancer. Lancet. 2005; 366:491-505.
2. Salvesen HB, Akslen LA. Molecular pathogenesis and prognostic factors in endometrial carcinoma. APMIS. 2002;110:673-689.
3. Lax SF. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch. 2004;444:213-223.
4. Creasman WT, Morrow CP, Bundy BN, et al. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer. 1987;60:2035-2041.
5. Benedet JL, Bender H, Jones H 3rd, et al. Staging classifications and clinical practice guidelines for gynaecological cancers. Int J Obstet Gynecol. 2000;70:207-312.
6. Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5:R80.
7. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(jDelta Delta C(T)) method. Methods. 2001;25:402-408.
8. Chen YC, Pohl G, Wang TL, et al. Apolipoprotein E is required for cell proliferation and survival in ovarian cancer. Cancer Res. 2005;65: 331-337.
9. Yu KH, Rustgi AK, Blair IA. Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry. J Proteome Res. 2005;4:1742-1751.
10. Venanzoni MC, Giunta S, Muraro GB, et al. Apolipoprotein E expression in localized prostate cancers. Int J Oncol. 2003;22:779-786.
11. Oue N, Hamai Y, Mitani Y, et al. Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 2004;64:2397-2405.
12. Ito Y, Takano T, Miyauchi A. Apolipoprotein e expression in anaplastic thyroid carcinoma. Oncology. 2006;71:388-393.
13. Nicoll JA, Zunarelli E, Rampling R, et al. Involvement of apolipoprotein E in glioblastoma: immunohistochemistry and clinical outcome. Neuroreport. 2003;14:1923-1926.
14. Engelsen IB, Stefansson I, Akslen LA, et al. Pathologic expression of p53 or p16 in preoperative curettage specimens identifies high-risk endometrial carcinomas. Am J Obstet Gynecol. 2006;195:979-986.
15. Morrison C, Zanagnolo V, Ramirez N, et al. HER2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients. J Clin Oncol. 2006;24: 2376-2385.
16. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622-630.
17. Elshourbagy NA, Liao WS, Mahley RW, et al. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci U S A. 1985;82:203-207.
18. Driscoll DM, Getz GS. Extrahepatic synthesis of apolipoprotein E. J Lipid Res. 1984;25:1368-1379.
19. Soeda S, Nakamuru N, Ozeki T, et al. Tumor-associated macrophages correlate with vascular space invasion and myometrial invasion in endometrial cancer. Gynecol Oncol. 2008;109:122-128.
20. Ding Y, Milosavljevic T, Alahari SK. Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion. Mol Cell Biol. 2008;28:3742-3756.