Endometrial and ovarian carcinomas with undifferentiated components: Clinically aggressive and frequently underrecognized neoplasms

Modern Pathology

Volumn 23, Issue 6, 2010, Pages 781-789

  Tafe, Laura J ^a   Garg, Karuna ^a   Chew, Ivy ^a   Tornos, Carmen ^b   Soslow, Robert A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

DNA mismatch repair; Endometrioid carcinoma; Endometrium; Malignant mixed Mullerian tumor; Ovary; Undifferentiated carcinoma

Indexed keywords

CYTOKERATIN 18; EPITHELIAL MEMBRANE ANTIGEN; ESTROGEN RECEPTOR; KERATIN; MISMATCH REPAIR PROTEIN; MISMATCH REPAIR PROTEIN PMS2; MSH6 MISMATCH REPAIR PROTEIN; PROGESTERONE RECEPTOR; TUMOR MARKER; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER GRADING; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CARCINOSARCOMA; CELL NUCLEUS; CELL SIZE; CLINICAL ARTICLE; CYTOLOGY; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; ENDOMETRIUM CARCINOMA; ENDOMETRIUM SARCOMA; EPITHELIOID SARCOMA; FEMALE; FOLLOW UP; GRANULOSA CELL TUMOR; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPHOMA; METASTASIS; MICROSATELLITE INSTABILITY; NEUROENDOCRINE TUMOR; OVARY CARCINOMA; PARAAORTIC LYMPH NODE METASTASIS; PELVIS METASTASIS; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SMOOTH MUSCLE; STROMA CELL; UNDIFFERENTIATED CARCINOMA;

ADULT; AGED; CARCINOMA; CARCINOMA, ENDOMETRIOID; CELL DIFFERENTIATION; DIAGNOSIS, DIFFERENTIAL; DNA MISMATCH REPAIR; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MICROSATELLITE INSTABILITY; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; OVARIAN NEOPLASMS; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 77953158268     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2010.41     Document Type: Article

References (17)

1. Tavassoli FA, Devilee P. World Health Organization Classification of Tumors: Tumors of the Breast and Female Genital Organs. IARC Press: Lyon, 2003.
2. Silva EG, Deavers MT, Bodurka DC, et al. Association of low grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma? Int J Gynecol Pathol 2006;25:52-58.
3. Altrabulsi B, Malpica A, Deavers MT, et al. Undiffer-entiated carcinoma of the endometrium. Am J Surg Pathol 2005;29:1316-1321.
4. Broaddus RR, Lynch HT, Chen LM, et al. Pathologic features of endometrial carcinoma associated with HNPCC. Cancer 2006;106:87-94.
5. Garg K, Leitao M, Kauff N, et al. Selection of endometrial carcinomas for DNA mismatch repair protein immuno-histochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities. Am J Surg Pathol 2009;33:925-933.
6. Ferguson SE, Tornos C, Hummer A, et al. Prognostic features of surgical stage I uterine carcinosarcomas. Am J Surg Pathol 2007;31:1653-1661.
7. Garg K, Leitao M, Guile M, et al. Undifferentiated uterine sarcomas: a diagnosis of exclusion with apparent prognostic significance. Mod Pathol 2008;21:225A.
8. Kurihara S, Oda Y, Ohishi Y, et al. Endometrial stromal sarcomas and related high grade sarcomas: immuno-histochemical and molecular genetic study of 31 cases. Am J Surg Pathol 2008;32:1228-1238.
9. O'Connell FP, Pinkus JL, Pinkus GS. CD138 (Syndecan-1), a plasma cell marker: immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol 2004;121:254-263.
10. Nigwekar P, Tamboli P, Amin MB, et al. Plasmacytoid urothelial carcinoma: detailed analysis of morphology with clinicopathologic correlation in 17 cases. Am J Surg Pathol 2009;33:417-424.
11. Hoot A, Russo P, Judkins AR, et al. Immunohisto-chemical analysis of h-SNF5/INI-1 distinguishes renal and extra-renal malignant rhabdoid tumor from other pediatric soft tissue sarcomas. Am J Surg Pathol 2004;28:1485-1491.
12. Al-Hussaini M, Hirschowitz L, McCluggage G. Uterine neoplasms composed of rhabdoid cells do not exhibit loss of INI1 immunoreactivity and are not related to childhood malignant rhabdoid tumor. Int J Gynecol Pathol 2008;27:236-242.
13. Cho KR, Rosenshein NB, Epstein JI. Malignant rhab-doid tumor of the uterus. Int J Gynecol Pathol 1989;8:381-387.
14. Gaertner EM, Farley JH, Taylor RR, et al. Collision of uterine rhabdoid tumor and endometrioid adenocarci-noma: a case report and review of the literature. Int J Gynecol Pathol 1999;18:396-401.
15. Mount SL, Lee KR, Taatjes DJ. Carcinosarcoma (malignant mixed Mullerian tumor) of the uterus with a rhabdoid tumor component. An immuno-histochemical, ultrastructural and immunoelectronmi-croscopic case study. Am J Clin Pathol 1995;103: 235-239.
16. Donner LR, Wainwright LM, Zhang F, et al. Mutation of the INI1 gene in composite rhabdoid tumor of the endometrium. Hum Pathol 2007;38:935-939.
17. Taraif SH, Deavers MT, Malpica A, et al. The significance of neuroendocrine expression in undiffer-entiated carcinoma of the endometrium. Int J Gynecol Pathol 2009;28:142-147.