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Volumn 62, Issue 9, 2009, Pages 777-785

Molecular pathology of endometrial carcinoma: Practical aspects from the diagnostic and therapeutic viewpoints

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; BETA CATENIN; BORTEZOMIB; DEFOROLIMUS; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; GEFITINIB; GESTAGEN; GOG 229C; HISTONE DEACETYLASE INHIBITOR; K RAS PROTEIN; LAPATINIB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIK3CA PROTEIN; PROTEASOME INHIBITOR; PROTEIN; PROTEIN P16; PROTEIN P53; RAPAMYCIN; RAPAMYCIN DERIVATIVE; SORAFENIB; TEMSIROLIMUS; TRASTUZUMAB; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 70349140898     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2008.056101     Document Type: Review
Times cited : (132)

References (65)
  • 1
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • Bockman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15:10-17
    • (1983) Gynecol Oncol , vol.15 , pp. 10-17
    • Bockman, J.V.1
  • 2
    • 0031297547 scopus 로고    scopus 로고
    • A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses
    • Lax SF, Kurman RJ. A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses. Verh Dtsch Ges Path 1997;81:228-232
    • (1997) Verh Dtsch Ges Path , vol.81 , pp. 228-232
    • Lax, S.F.1    Kurman, R.J.2
  • 6
    • 0029122057 scopus 로고
    • Microsatellite instability in endometrial carcinomas: Frequent replication errors in tumors of early onset and/or of poorly differentiated type
    • Kobayashi K, Sagae S, Kudo H, et al. Microsatellite instability in endometrial carcinomas: frequent replication errors in tumors of early onset and/or of poorly differentiated type. Genes Chromosom Cancer 1995;14:128-132
    • (1995) Genes Chromosom Cancer , vol.14 , pp. 128-132
    • Kobayashi, K.1    Sagae, S.2    Kudo, H.3
  • 8
    • 0031690464 scopus 로고    scopus 로고
    • Microsatellite instability in endometrial carcinomas: Clinicopathologic correlations in a series of 42 cases
    • DOI 10.1016/S0046-8177(98)90430-0
    • Catasús LI, Machin P, Matias-Guiu X, et al. Microsatellite instability in endometrial carcinomas clinicopathologic correlations in a series of 42 cases. Hum Pathol 1998;29:1160-1164 (Pubitemid 28467540)
    • (1998) Human Pathology , vol.29 , Issue.10 , pp. 1160-1164
    • Catasus, L.1    Machin, P.2    Matias-Guiu, X.3    Prat, J.4
  • 9
    • 0032487831 scopus 로고    scopus 로고
    • MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
    • Esteller M, Levine R, Baylin SB, et al. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 1998;17:2413-2417 (Pubitemid 28515395)
    • (1998) Oncogene , vol.17 , Issue.18 , pp. 2413-2417
    • Esteller, M.1    Levine, R.2    Baylin, S.B.3    Ellenson, L.H.4    Herman, J.G.5
  • 10
    • 0032706744 scopus 로고    scopus 로고
    • HMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis
    • Esteller M, Catasus LI, Matias-Guiu X, et al. hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis. Am J Pathol 1999;155:1767-1772
    • (1999) Am J Pathol , vol.155 , pp. 1767-1772
    • Esteller, M.1    Catasus, L.I.2    Matias-Guiu, X.3
  • 11
    • 0033556428 scopus 로고    scopus 로고
    • Causes and consequences of microsatellite instability in endometrial carcinoma
    • Gurin ChC, Federici MG, Kang L, et al. Causes and consequences of microsatellite instability in endometrial carcinoma. Cancer Res 1999;59:462-466 (Pubitemid 29048884)
    • (1999) Cancer Research , vol.59 , Issue.2 , pp. 462-466
    • Gurin, C.C.1    Federici, M.G.2    Kang, L.3    Boyd, J.4
  • 13
    • 0034667718 scopus 로고    scopus 로고
    • Clinical significance of microsatellite instability in endometrial carcinoma
    • DOI 10.1002/1097-0142(20001015)89:8<1758::AID-CNCR16>3.0.CO;2-A
    • Basil JB, Goodfellow PJ, Rader JS, et al. Clinical significance of microsatellite instability in endometrial carcinoma. Cancer 2000;89:1758-1764 (Pubitemid 30794170)
    • (2000) Cancer , vol.89 , Issue.8 , pp. 1758-1764
    • Basil, J.B.1    Goodfellow, P.J.2    Rader, J.S.3    Mutch, D.G.4    Herzog, T.J.5
  • 15
    • 0031761109 scopus 로고    scopus 로고
    • BAX somatic frameshift mutations in endometrioid adenocarcinomas of the endometrium: Evidence for a tumor progression role in endometrial carcinomas with microsatellite instability
    • Catasus LI, Matias-Guiu X, Machin P, et al. BAX somatic framshift mutations in endometrioid adenocarcinomas of the endometrium: evidence for a tumor progression role in endometrioid carcinomas with microsatellite instability. Lab Invest 1998;78:1439-1444 (Pubitemid 28546087)
    • (1998) Laboratory Investigation , vol.78 , Issue.11 , pp. 1439-1444
    • Catasus, L.1    Matias-Guiu, X.2    Machin, P.3    Munoz, J.4    Prat, J.5
  • 16
    • 0034657583 scopus 로고    scopus 로고
    • Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinoma with microsatellite instability
    • DOI 10.1002/(SICI)1097-0142(20000515)88:10<2290::AID-CNCR13>3.0. CO;2-I
    • Catasus LI, Matias-Guiu X, Machin P, et al. Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinomas with microsatellite instability. Cancer 2000;88:2290-2297 (Pubitemid 30247129)
    • (2000) Cancer , vol.88 , Issue.10 , pp. 2290-2297
    • Catasus, L.1    Matias-Guiu, X.2    Machin, P.3    Zannoni, G.F.4    Scambia, G.5    Benedetti-Panici, P.6    Prat, J.7
  • 17
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000;92:924-931
    • (2000) J Natl Cancer Inst , vol.92 , pp. 924-931
    • Mutter, G.L.1    Lin, M.C.2    Fitzgerald, J.T.3
  • 18
    • 0038274803 scopus 로고    scopus 로고
    • Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer
    • DOI 10.1677/erc.0.0100203
    • Terakawa N, Kanamori Y, Yoshida S. Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer. Endocr Relat Cancer 2003;10:203-208 (Pubitemid 36758649)
    • (2003) Endocrine-Related Cancer , vol.10 , Issue.2 , pp. 203-208
    • Terakawa, N.1    Kanamori, Y.2    Yoshida, S.3
  • 19
    • 0037089643 scopus 로고    scopus 로고
    • Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma
    • DOI 10.1002/cncr.10434
    • Salvesen HB, Stefansson I, Kalvenes MB, et al. Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma. Cancer 2002;94:2185-2191 (Pubitemid 34411976)
    • (2002) Cancer , vol.94 , Issue.8 , pp. 2185-2191
    • Salvesen, H.B.1    Stefansson, I.2    Kalvenes, M.B.3    Das, S.4    Akslen, L.A.5
  • 21
    • 0034019805 scopus 로고    scopus 로고
    • PTEN mutations in endometrial carcinomas. a molecular and clinicopathologic analysis of 38 cases
    • Bussaglia E, del Rio E, Matias-Guiu X, et al. PTEN mutations in endometrial carcinomas. A molecular and clinicopathologic analysis of 38 cases. Hum Pathol 2000;31:312-317
    • (2000) Hum Pathol , vol.31 , pp. 312-317
    • Bussaglia, E.1    Del Rio, E.2    Matias-Guiu, X.3
  • 23
    • 84984777123 scopus 로고    scopus 로고
    • PTEN1 is frequently mutated in primary endometrial carcinomas
    • Kong D, Suzuki A, Zou TT, et al. PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet 1997;17:143-144
    • (1997) Nat Genet , vol.17 , pp. 143-144
    • Kong, D.1    Suzuki, A.2    Zou, T.T.3
  • 24
    • 0030781053 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in endometrial cancers
    • Risinger JI, Hayes AK, Berchuck A, et al. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 1997;57:4736-4738
    • (1997) Cancer Res , vol.57 , pp. 4736-4738
    • Risinger, J.I.1    Hayes, A.K.2    Berchuck, A.3
  • 25
    • 0032146038 scopus 로고    scopus 로고
    • PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma
    • Levine RL, Cargile CB, Blazes MS, et al. PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. Cancer Res 1998;58:3254-3258
    • (1998) Cancer Res , vol.58 , pp. 3254-3258
    • Levine, R.L.1    Cargile, C.B.2    Blazes, M.S.3
  • 26
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • DOI 10.1158/0008-5472.CAN-05-2620
    • Oda K, Stokoe D, Taketani Y, et al. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res 2005;65:10669-10673 (Pubitemid 41713332)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3    McCormick, F.4
  • 29
    • 38649090091 scopus 로고    scopus 로고
    • PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
    • DOI 10.1038/modpathol.3800992, PII 3800992
    • Catasus L, Gallardo A, Cuatrecasas M, et al. PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters. Mod Pathol 2008;21:131-139 (Pubitemid 351172164)
    • (2008) Modern Pathology , vol.21 , Issue.2 , pp. 131-139
    • Catasus, L.1    Gallardo, A.2    Cuatrecasas, M.3    Prat, J.4
  • 30
    • 0032953788 scopus 로고    scopus 로고
    • Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability
    • Swisher EM, Peiffer-Scheider S, Mutch DG, et al. Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability. Cancer 1999;85:119-126
    • (1999) Cancer , vol.85 , pp. 119-126
    • Swisher, E.M.1    Peiffer-Scheider, S.2    Mutch, D.G.3
  • 31
    • 0035150494 scopus 로고    scopus 로고
    • K-ras mutations in endometrial carcinomas with microsatellite instability
    • DOI 10.1002/1096-9896(2000)9999:9999<::AID-PATH769>3.0.CO;2-9
    • Lagarda H, Catasus LI, Argüelles R, et al. K-ras mutations in endometrial carcinoma with microsatellite instability. J Pathol 2001;193:193-199 (Pubitemid 32118131)
    • (2001) Journal of Pathology , vol.193 , Issue.2 , pp. 193-199
    • Lagarda, H.1    Catasus, L.2    Arguelles, R.3    Matias-Guiu, X.4    Prat, J.5
  • 36
    • 0033784576 scopus 로고    scopus 로고
    • Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma
    • Schlosshauer PW, Pirog EC, Levine RL, et al. Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma. Mod Pathol 2000;13:1066-1071
    • (2000) Mod Pathol , vol.13 , pp. 1066-1071
    • Schlosshauer, P.W.1    Pirog, E.C.2    Levine, R.L.3
  • 37
    • 0036219634 scopus 로고    scopus 로고
    • CTNNB1 mutations and beta-catenin expression in endometrial carcinomas
    • DOI 10.1053/hupa.2002.30723
    • Machin P, Catasus L, Pons C, et al. CTNNB1 mutations and beta-catenin expression in endometrial carcinomas. Hum Pathol 2002;33:206-212 (Pubitemid 34298736)
    • (2002) Human Pathology , vol.33 , Issue.2 , pp. 206-212
    • Machin, P.1    Catasus, L.2    Pons, C.3    Muoz, J.4    Matias-Guiu, X.5    Prat, J.6
  • 40
    • 0028887101 scopus 로고
    • P53 in endometrial cancer and its putative precursors: Evidence for diverse pathways of tumorigenesis
    • Sherman ME, Bur ME, Kurman RJ. p53 in endometrial cancer and its putative precursors: evidence for diverse pathways of tumorigenesis. Hum Pathol 1995;26:1268-1274
    • (1995) Hum Pathol , vol.26 , pp. 1268-1274
    • Sherman, M.E.1    Bur, M.E.2    Kurman, R.J.3
  • 45
    • 0030958307 scopus 로고    scopus 로고
    • Loss of heterozygosity in usual and special variant carcinomas of the endometrium
    • DOI 10.1016/S0046-8177(97)90084-8
    • Tritz D, Pieretti M, Turner S, et al. Loss of heterozygosity in usual and special variant carcinomas of the endometrium, Hum Pathol 1997;28:607-612 (Pubitemid 27213058)
    • (1997) Human Pathology , vol.28 , Issue.5 , pp. 607-612
    • Tritz, D.1    Pieretti, M.2    Turner, S.3    Powell, D.4
  • 48
    • 22544479422 scopus 로고    scopus 로고
    • FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis
    • DOI 10.1038/labinvest.3700286
    • Dolcet X, Llobet D, Pallares J, et al. FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis. Lab Invest 2005;85:885-894 (Pubitemid 41021297)
    • (2005) Laboratory Investigation , vol.85 , Issue.7 , pp. 885-894
    • Dolcet, X.1    Llobet, D.2    Pallares, J.3    Rue, M.4    Comella, J.X.5    Matias-Guiu, X.6
  • 51
    • 0037226389 scopus 로고    scopus 로고
    • Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer
    • Risinger JI, Maxwell GL, Chandramouli GV, et al. Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer. Cancer Res 2003;63:6-11.
    • (2003) Cancer Res , vol.63 , pp. 6-11
    • Risinger, J.I.1    Maxwell, G.L.2    Chandramouli, G.V.3
  • 52
    • 20344383528 scopus 로고    scopus 로고
    • Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer
    • DOI 10.1158/1078-0432.CCR-04-2001
    • Maxwell GL, Chandramouli GV, Dainty L, et al. Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer. Clin Cancer Res 2005;11:4056-4066 (Pubitemid 40791569)
    • (2005) Clinical Cancer Research , vol.11 , Issue.11 , pp. 4056-4066
    • Maxwell, G.L.1    Chandramouli, G.V.R.2    Dainty, L.3    Litzi, T.J.4    Berchuck, A.5    Barrett, J.C.6    Risinger, J.I.7
  • 54
    • 20444447557 scopus 로고    scopus 로고
    • Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling
    • Risinger JI, Maxwell GL, Chandramouli GV, et al. Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling. Cancer Res 2005;65:5031-5037
    • (2005) Cancer Res , vol.65 , pp. 5031-5037
    • Risinger, J.I.1    Maxwell, G.L.2    Chandramouli, G.V.3
  • 55
    • 20144387395 scopus 로고    scopus 로고
    • Histologic type, organ of origin, and Wnt pathway status: Effect on gene expression in ovarian and uterine carcinomas
    • Shedden KA, Kshirsagar MP, Schwartz DR, et al. Histologic type, organ of origin, and Wnt pathway status: effect on gene expression in ovarian and uterine carcinomas. Clin Cancer Res 2005;11:2123-2131
    • (2005) Clin Cancer Res , vol.11 , pp. 2123-2131
    • Shedden, K.A.1    Kshirsagar, M.P.2    Schwartz, D.R.3
  • 61
    • 37849018320 scopus 로고    scopus 로고
    • Antioxidants block proteasome inhibitor function in endometrial carcinoma cells
    • Llobet D, Eritja N, Encinas M, et al. Antioxidants block proteasome inhibitor function in endometrial carcinoma cells. Anticancer Drugs 2008;19:115-124
    • (2008) Anticancer Drugs , vol.19 , pp. 115-124
    • Llobet, D.1    Eritja, N.2    Encinas, M.3
  • 62
    • 21244441901 scopus 로고    scopus 로고
    • Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus
    • Gunin AG, Kapitova IN, Suslonova NV. Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. J Endocrinol 2005;185:539-549
    • (2005) J Endocrinol , vol.185 , pp. 539-549
    • Gunin, A.G.1    Kapitova, I.N.2    Suslonova, N.V.3
  • 65
    • 21544457787 scopus 로고    scopus 로고
    • Synchronous endometrioid carcinomas of the uterine corpus and ovary: Alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis
    • DOI 10.1016/j.humpath.2005.03.005, PII S0046817705001292
    • Irving JA, Catasús L, Gallardo A, et al. Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis. Hum Pathol 2005;36:605-619 (Pubitemid 40922566)
    • (2005) Human Pathology , vol.36 , Issue.6 , pp. 605-619
    • Irving, J.A.1    Catasus, L.2    Gallardo, A.3    Bussaglia, E.4    Romero, M.5    Matias-Guiu, X.6    Prat, J.7


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