1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity

European Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2008, Pages 1665-1680

  Roma, Giorgio ^a   Grossi, Giancarlo ^a   Di Braccio, Mario ^a   Piras, Daniela ^a   Ballabeni, Vigilio ^b   Tognolini, Massimiliano ^b   Bertoni, Simona ^b   Barocelli, Elisabetta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

1,2,4 Triazolo 4,3 a 1,8 naphthyridines; Analgesic; Anti inflammatory; Gastrolesivity; Isosteric analogues; Structure activity relationships

Indexed keywords

1,8 NAPHTHYRIDINE DERIVATIVE; INDOMETACIN; N,N DIETHYL 5 (4 METHYL 1 PIPERAZINYL)[1,2,4]TRIAZOLO[4,3 A]QUINOLINE 4 CARBOXAMIDE; N,N DIETHYL 5 (ETHYLAMINO) 1 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A]QUINOLINE 4 CARBOXAMIDE; N,N DIETHYL 5 (N ETHYL N METHYLAMINO) 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; UNCLASSIFIED DRUG;

ACUTE GASTROLESIVITY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; GASTROINTESTINAL TOXICITY; MALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; WRITHING TEST;

ACUTE DISEASE; AMIDES; AMINES; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DANAZOL; FEMALE; MALE; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; NAPHTHYRIDINES; RATS; STOMACH DISEASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47949098766     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.10.010     Document Type: Article

References (16)

1. Roma G., Grossi G.C., Di Braccio M., Ghia M., and Mattioli F. Eur. J. Med. Chem. 26 (1991) 489-496
2. Grossi G.C., Di Braccio M., Roma G., Ballabeni V., Tognolini M., Calcina F., and Barocelli E. Eur. J. Med. Chem. 37 (2002) 933-944
3. Roma G., Di Braccio M., Grossi G.C., Mattioli F., and Ghia M. Eur. J. Med. Chem. 35 (2000) 1021-1035
4. Grossi G.C., Di Braccio M., Roma G., Ballabeni V., Tognolini M., and Barocelli E. Eur. J. Med. Chem. 40 (2005) 155-165
5. Dianzani C., Collino M., Gallicchio M., Di Braccio M., Roma G., and Fantozzi R. J. Inflamm. 3 (2006) 4.
6. Koller G. Chem. Ber. 60 (1927) 407-410
7. Di Braccio M., Roma G., Balbi A., Sottofattori E., and Carazzone M. Farmaco 44 (1989) 865-881
8. Di Braccio M., Roma G., Grossi G.C., Ghia M., and Mattioli F. Farmaco 52 (1997) 49-53
9. Reisch J., Salehi-Artimani R.A., Bathe A., and Muller M. Monatsh. Chem. 119 (1988) 781-791
10. Raehal K.M., and Bohn L.M. A.A.P.S.J. 7 (2005) E587-E591
11. Eisenach J.C. Life Sci. 64 (1999) 549-554
12. Jain K.K. Curr. Opin. Investig. Drugs 5 (2004) 76-81
13. Lopez-Garcia J.A. Curr. Top. Med. Chem. 6 (2006) 1987-1996
14. Mohamed E.A., Abdel-Rahman R.M., El-Gendy Z., and Ismail M.M. Comm. Fac. Sci. Univ. Ankara Ser. B: Chem. and Chem. Engin. 40 1-2 (1996) 1-12
15. Winter C.A., Risley E.A., and Nuss G.W. J. Pharmacol. Exp. Ther. 141 (1963) 369-376
16. Koster R., Anderson M., and De Beer E.J. Fed. Proc. 18 (1959) 412-421