Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 882-895

  Rostom, Sherif A F ^a   El Ashmawy, Ibrahim M ^b   Abd El Razik, Heba A ^b   Badr, Mona H ^b   Ashour, Hayam M A ^b  

^a King Abdulaziz University   (Saudi Arabia)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

1,3,4 Thiadiazoles; Acute toxicity; Analgesic activity; Anti inflammatory activity; Antimicrobial activity; Antipyrine; Thiazoles; Ulcerogenic effect

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; 2 (5 ACETAMIDO 1,3,4 THIADIAZOL 2 YLTHIO) N (2,5 DIHYDRO 2,3 DIMETHYL 5 OXO 1 PHENYL 1H PYRAZOL 4 YL)ACETAMIDE; 2 (5 AMINO 1,3,4 THIADIAZOL 2 YLTHIO) N (2,5 DIHYDRO 2,3 DIMETHYL 5 OXO 1 PHENYL 1H PYRAZOL 4 YL)ACETAMIDE; 2 CYANO N (2,5 DIHYDRO 2,3 DIMETHYL 5 OXO 1 PHENYL 1H PYRAZOL 4 YL) 2 [3 (4 CHLOROPHENYL) 4 OXOTHIAZOLIDIN 2 YLIDENE]ACETAMIDE; 4 AMINO 2 (DICYANOMETHYLENE) 2,3 DIHYDRO N (2,5 DIHYDRO 2,3 DIMETHYL 5 OXO 1 PHENYL 1H PYRAZOL 4 YL) 3 PHENYLTHIAZOLE 5 CARBOXAMIDE; AMPICILLIN; ANALGESIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CLOTRIMAZOLE; DICLOFENAC; ETHYL 2 [5 (2,5 DIHYDRO 2,3 DIMETHYL 5 OXO 1 PHENYL 1H PYRAZOL 4 YLCARBAMOYL) 4 AMINO 3 PHENYLTHIAZOL 2(3H) YLIDENE] 2 CYANOACETATE; N (2,5 DIHYDRO 2,3 DIMETHYL 5 OXO 1 PHENYL 1H PYRAZOL 4 YL) 3 PHENYL 4 (3 PHENYLTHIOUREIDO) 2 THIOXO 2,3 DIHYDROTHIAZOLE 5 CARBOXAMIDE; N (2,5 DIHYDRO 2,3 DIMETHYL 5 OXO 1 PHENYL 1H PYRAZOL 4 YL) 3 PHENYL 4 [3 (4 CHLOROPHENYL)THIOUREIDO] 2 THIOXO 2,3 DIHYDROTHIAZOLE 5 CARBOXAMIDE; PHENAZONE DERIVATIVE; THIADIAZOLYL DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SAFETY; DRUG SYNTHESIS; DRUG TOLERABILITY; MALE; NONHUMAN; RAT; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; THIAZOLES;

ANIMALIA; RATTUS;

EID: 58549117092     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.035     Document Type: Article

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