1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity

European Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2010, Pages 352-366

  Roma, Giorgio ^a   Di Braccio, Mario ^a   Grossi, Giancarlo ^a   Piras, Daniela ^a   Ballabeni, Vigilio ^b   Tognolini, Massimiliano ^b   Bertoni, Simona ^b   Barocelli, Elisabetta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

1,2,4 Triazolo 4,3 a 1,8 naphthyridines; Analgesic; Anti inflammatory; Gastric damage; Imidazo 1,2 a 1,8 naphthyridines; Structure activity relationships

Indexed keywords

5 (ALLYLAMINO) N,N DIETHYL 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; 5 AMINO(1,2,4)TRIAZOLO(4,3 A)(1,8)NAPHTHYRIDINE 6 CARBOXAMIDE DERIVATIVE; 5 AMINOIMIDAZO(1,2 A)(1,8)NAPHTHYRIDINE 6 CARBOXAMIDE DERIVATIVE; [5 (ISOBUTYLAMINO) 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8 NAPHTHYRIDIN 6 YL] (4 METHYL 1 PIPERAZINYL)METHANONE; ETHYL 6 (DIETHYLCARBAMOYL) 5 (4 METHYL 1 PIPERAZINYL)IMIDAZO[1,2 A][1,8]NAPHTHYRIDINE 8 CARBOXYLATE; N ETHYL 5 (ISOBUTYLAMINO) 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N ETHYL N METHYL 9 ISOPROPYL 5 (ISOPROPYLAMINO)[1,2,4]TRITRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N DIETHYL 5 (ISOBUTYLAMINO) 9 METHYLIMIDAZO[1,2 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N DIETHYL 5 (ISOBUTYLAMINO)IMIDAZO[1,2 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N DIETHYL 9 (DIMETHYLAMINO) 5 (4 METHYL 1 PIPERAPIPERAZINYL)IMIDAZO[1,2 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N DIETHYL 9 ETHOXY 5 (4 METHYL 1 PIPERAZINYL)IMIDAZO[1,2 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N DIETHYL 9 ETHYL 5 (N ISOBUTYL,N METHYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N DIETHYL 9 ISOPROPYL 5 (N METHYL,N PROPYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]]NAPHTHYRIDINE 6 CARBOXAMIDE; NAPHTHYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; LOCOMOTION; MALE; MOUSE; NONHUMAN; RAT; STOMACH INJURY;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; EDEMA; FEMALE; MALE; MICE; MOTOR ACTIVITY; NAPHTHYRIDINES; RATS; STOMACH;

EID: 72049100662     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.020     Document Type: Article

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