1,8-Naphthyridines V. Novel N-substituted 5-amino-N,N-diethyl-9-isopropyl [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity

European Journal of Medicinal Chemistry

Volumn 40, Issue 2, 2005, Pages 155-165

  Grossi, Giancarlo ^a   Di Braccio, Mario ^a   Roma, Giorgio ^a   Ballabeni, Vigilio ^b   Tognolini, Massimiliano ^b   Barocelli, Elisabetta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

1,2,4 Triazolo 4,3 a 1,8 naphthyridines; Analgesic; Anti inflammatory; Gastrolesivity; Structure activity relationships

Indexed keywords

5 (BUTYLAMINO) N,N DIETHYL 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; 5 (CYCLOPROPYLAMINO) N,N DIETHYL 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; 5 (DIETHYLAMINO) N,N DIETHYL 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; AMINE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CHLORINE DERIVATIVE; DIAZEPAM; HYDRAZIDE DERIVATIVE; INDOMETACIN; N,N DIETHYL 9 ISOPROPYL 5 (PHENYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; NAPHTHYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HYPOTHERMIA; LOCOMOTION; MALE; MOUSE; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH MUCOSA LESION; TOXICITY TESTING;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEVER; HYPOTHERMIA; MOTOR ACTIVITY; NAPHTHYRIDINES; RATS; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13444267587     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.09.022     Document Type: Article

References (10)

1. M. Di Braccio, G. Roma, G.C. Grossi, M. Ghia, and E. Mereto Eur. J. Med. Chem. 25 1990 681 687
2. G. Roma, G.C. Grossi, M. Di Braccio, M. Ghia, and F. Mattioli Eur. J. Med. Chem. 26 1991 489 496
3. G.C. Grossi, M. Di Braccio, G. Roma, V. Ballabeni, M. Tognolini, F. Calcina, and E. Barocelli Eur. J. Med. Chem. 37 2002 933 944
4. M. Di Braccio, G. Roma, A. Balbi, E. Sottofattori, and M. Carazzone Farmaco 44 1989 865 881
5. M. Di Braccio, G. Roma, M. Ghia, and F. Mattioli Farmaco 49 1994 25 32
6. M. Di Braccio, G. Roma, G.C. Grossi, M. Ghia, and F. Mattioli Farmaco 52 1997 49 53
7. G. Roma, M. Di Braccio, G.C. Grossi, F. Mattioli, and M. Ghia Eur. J. Med. Chem. 35 2000 1021 1035
8. C.A. Winter, E.A. Risley, and G.W. Nuss J. Pharmacol. Exp. Ther. 141 1963 369 376
9. R. Koster, M. Anderson, and E.J. De Beer Fed. Proc. 18 1959 412 421
10. A.A. Romanovsky, V.A. Kulchitsky, and N.V. Akulich Am. J. Physiol. 40 1996 R244