Preclinical and the first clinical studies on [11C]ITMM for mapping metabotropic glutamate receptor subtype 1 by positron emission tomography

Nuclear Medicine and Biology

Volumn 40, Issue 2, 2013, Pages 214-220

  Toyohara, Jun ^a   Sakata, Muneyuki ^a   Fujinaga, Masayuki ^b   Yamasaki, Tomoteru ^b   Oda, Keiichi ^a   Ishii, Kenji ^a   Zhang, Ming Rong ^b   Moriguchi Jeckel, Cristina Maria ^a,c   Ishiwata, Kiichi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

11C ITMM; Central nervous system; Metabotropic glutamate receptor type 1; Positron emission tomography

Indexed keywords

METABOTROPIC RECEPTOR 1; N [4 [6 (ISOPROPYLAMINO)PYRIMIDIN 4 YL] 1,3 THIAZOL 2 YL] 4 METHOXY N METHYLBENZAMIDE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ADULT; AMES TEST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DISTRIBUTION VOLUME; DOSIMETRY; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN EXPERIMENT; MALE; METHYLATION; MOUSE; MUTAGENICITY; NONHUMAN; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE; RADIOACTIVITY; THALAMUS;

ADULT; ANIMALS; BENZAMIDES; BRAIN; CARBON RADIOISOTOPES; HUMANS; MALE; MICE; MOLECULAR IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RADIOMETRY; RECEPTORS, METABOTROPIC GLUTAMATE; THIAZOLES; TOXICITY TESTS;

EID: 84872966862     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2012.11.008     Document Type: Article

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