Characterization of 1-(2-[ 18F]fluoro-3-pyridyl)-4-(2-isopropyl- 1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains

Journal of Neurochemistry

Volumn 121, Issue 1, 2012, Pages 115-124

  Fujinaga, Masayuki ^a   Maeda, Jun ^a   Yui, Joji ^a   Hatori, Akiko ^a   Yamasaki, Tomoteru ^a   Kawamura, Kazunori ^a   Kumata, Katsushi ^a   Yoshida, Yuichiro ^a,b   Nagai, Yuji ^a   Higuchi, Makoto ^a   Suhara, Tetsuya ^a   Fukumura, Toshimitsu ^a   Zhang, Ming Rong ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b 141 0032   (Japan)

Author keywords

18F FPIT; autoradiography; metabotropic glutamate receptor type 1; monkey PET; small animal PET

Indexed keywords

1 (2 FLUORO 2 PYRIDYL) 4 (2 ISOPROPYL 1 OXO ISOINDOLIN 5 YL) 5 METHYL 1H 1,2,3 TRIAZOLE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HAPLORHINI; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR IMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; FLUORINE RADIOISOTOPES; INDOLES; LIGANDS; MACACA MULATTA; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SPECIES SPECIFICITY; TRIAZOLES;

ANIMALIA; RATTUS;

EID: 84858709063     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07348.x     Document Type: Article

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