Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [ 18F]FITM

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 39, Issue 4, 2012, Pages 632-641

  Yamasaki, Tomoteru ^a,b   Fujinaga, Masayuki ^a   Maeda, Jun ^a   Kawamura, Kazunori ^a   Yui, Joji ^a   Hatori, Akiko ^a   Yoshida, Yuichiro ^a,c   Nagai, Yuji ^a   Tokunaga, Masaki ^a   Higuchi, Makoto ^a   Suhara, Tetsuya ^a   Fukumura, Toshimitsu ^a   Zhang, Ming Rong ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c 141 0032   (Japan)

Author keywords

18F FITM; Autoradiography; Metabotropic glutamate receptor subtype 1; PET

Indexed keywords

4 [18 FLUORINE]FLUORO N [4 [6 (ISOPROPYLAMINO)PYRIMIDIN 4 YL] 1,3 THIAZOL 2 YL] N METHYLBENZAMIDE; CONTRAST MEDIUM; DRUG METABOLITE; FLUORINE 18; JNJ 16259685; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BRAIN; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DISTRIBUTION; DRUG UPTAKE; HAPLORHINI; HIPPOCAMPUS; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; PONS; POSITRON EMISSION TOMOGRAPHY; PROTEIN LOCALIZATION; RADIOACTIVITY; RAT; THALAMUS;

ANIMALS; AUTORADIOGRAPHY; BENZAMIDES; BRAIN; FEASIBILITY STUDIES; HAPLORHINI; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; THIAZOLES;

EID: 84862518776     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-011-1995-6     Document Type: Article

References (31)

1. Schoepp DD. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 2001;299: 12-20.
2. Knöpfel T, Grandes P. Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells. Cerebellum 2002;1: 19-26.
3. Smith Y, Charara A, Hanson JE, Paquet M, Levey AI. GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates. J Anat 2000;196(Pt 4) : 555-76.
4. Netzeband JG, Parsons KL, Sweeney DD, Gruol DL. Metabotropic glutamate receptor agonists alter neuronal excitability and Ca2+ levels via the phospholipase C transduction pathway in cultured Purkinje neurons. J Neurophysiol 1997;78: 63-75.
5. Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, Wroblewski JT. The protective signaling of metabotropic glutamate receptor 1 is mediated by sustained, beta-arrestin-1- dependent ERK phosphorylation. J Biol Chem 2010;285: 26041-8.
6. Pshenichkin S, DolińskaM, Klauzińska M, LuchenkoV, Grajkowska E, Wroblewski JT. Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation- possible role as a dependence receptor. Neuropharmacology 2008;55: 500-8.
7. Zhou M, Xu W, Liao G, Bi X, Baudry M. Neuroprotection against neonatal hypoxia/ischemia-induced cerebral cell death by prevention of calpain-mediated mGluR1alpha truncation. Exp Neurol 2009;218: 75-82.
8. Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M. Differential expression patterns of mGluR1 alpha in monkey nigral dopamine neurons. Neuroreport 2003;14: 947-50.
9. Huang Y, Narendran R, Bischoff F, Guo N, Zhu Z, Bae SA, et al. A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C] methyl-6-quinolinyl) (cis-4- methoxycyclohexyl) methanone. J Med Chem 2005;48: 5096-9.
10. Ohgami M, Haradahira T, Takai N, Zhang MR, Kawamura K, Yamasaki T, Yanamoto K. [18F]FTIDC: a new PET radioligand for metabotropic glutamate receptor 1. Eur J Nucl Med Mol Imaging 2009;36: S310.
11. Yanamoto K, Konno F, Odawara C, Yamasaki T, Kawamura K, Hatori A, et al. Radiosynthesis and evaluation of [11C]YM- 202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1. Nucl Med Biol 2010;37: 615-24.
12. Hostetler ED, Eng W, Joshi AD, Sanabria-Bohórquez S, Kawamoto H, Ito S, et al. Synthesis, characterization, andmonkey PETstudies of [18F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435. Synapse 2011;65: 125-35.
13. Prabhakaran J, Majo VJ, Milak MS, Kassir SA, Palner M, Savenkova L, et al. Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors. Bioorg Med Chem Lett 2010;20: 3499-501.
14. Fujinaga M, Maeda J, Yui J, Hatori A, Yamasaki T, Kawamura K, et al. Characterization of 1-(2-[18F]fluoro-3-pyridyl) -4-(2- isopropyl-1-oxo- isoindoline-5-yl) -5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains. J Neurochem 2011. doi: 10.1111/j.1471-4159.2011.07348.x.
15. Fujinaga M, Yamasaki T, Kawamura K, Kumata K, Hatori A, Yui J, et al. Synthesis and evaluation of 6-[1-(2-[18F]fluoro-3- pyridyl) -5-methyl-1H-1,2,3- triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem 2011;19: 102-10.
16. Satoh A, Nagatomi Y, Hirata Y, Ito S, Suzuki G, Kimura T, et al. Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6- (isopropylamino) pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methy lbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist. Bioorg Med Chem Lett 2009;19: 5464-8.
17. Yamasaki T, Fujinaga M, Yoshida Y, Kumata K, Yui J, Kawamura K, et al. Radiosynthesis and preliminary evaluation of 4-[18F] fluoro-N-[4-[6- (isopropylamino) pyrimidin-4-yl]-1,3-thiazol-2-yl]- N- methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1. Bioorg Med Chem Lett 2011;21: 2998-3001.
18. Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, et al. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology 2004;47: 961-72.
19. Salt TE, Binns KE, Turner JP, Gasparini F, Kuhn R. Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl) -pyridine (MPEP) in the thalamus. Br J Pharmacol 1999;127: 1057-9.
20. Takei M, Kida T, Suzuki K. Sensitive measurement of positron emitters eluted from HPLC. Appl Radiat Isot 2001;55: 229-34.
21. Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr 1974;AC19: 716-23.
22. Fujita M, Seibyl JP, Verhoeff NP, Ichise M, Baldwin RM, Zoghbi SS, et al. Kinetic and equilibrium analyses of [(123) I]epidepride binding to striatal and extrastriatal dopamine D(2) receptors. Synapse 1999;34: 290-304.
23. Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-) - cocaine PET studies in human subjects. J Cereb Blood Flow Metab 1990;10: 740-7.
24. Fotuhi M, Sharp AH, Glatt CE, Hwang PM, von Krosigk M, Snyder SH, et al. Differential localization of phosphoinositidelinked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain. J Neurosci 1993;13: 2001-12.
25. Sarkadi B, Homolya L, Szakács G, Váradi A. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiol Rev 2006;86: 1179-236.
26. Ferraguti F, Crepaldi L, Nicoletti F. Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol Rev 2008;60: 536-81.
27. Ferraguti F, Shigemoto R. Metabotropic glutamate receptors. Cell Tissue Res 2006;326: 483-504.
28. Waterhouse RN. Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents. Mol Imaging Biol 2003;5: 376-89.
29. Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol 2003;63: 1082-93.
30. Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, Nambu A, et al. Down-regulation of metabotropic glutamate receptor 1alpha in globus pallidus and substantia nigra of parkinsonian monkeys. Eur J Neurosci 2005;22: 3241-54.
31. Roselli F, Hutzler P,Wegerich Y, Livrea P, Almeida OF. Disassembly of shank and homer synaptic clusters is driven by soluble betaamyloid( 1-40) through divergent NMDAR-dependent signaling pathways. PLoS One 2009;4: e6011.