Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2342-2352

  Fujinaga, Masayuki ^a   Yamasaki, Tomoteru ^a,b   Yui, Joji ^a   Hatori, Akiko ^a   Xie, Lin ^a   Kawamura, Kazunori ^a   Asagawa, Chiharu ^a   Kumata, Katsushi ^a   Yoshida, Yuichiro ^a,c   Ogawa, Masanao ^a,c   Nengaki, Nobuki ^a,c   Fukumura, Toshimitsu ^a   Zhang, Ming Rong ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c 141 0032   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 18 FLUOROETHOXY N 4 6 ISOPROPYLAMINO PYRIMIDIN 4 YL 1,3 THIAZOL 2YL N METHYLBENZAMIDE; 4 18 FLUOROPROPOXY N 4 6 ISOPROPYLAMINO PYRIMIDIN 4 YL 1,3 THIAZOL 2 YL N METHYLBENZAMIDE; 4 PYRIMIDINYL 2 METHYLAMINOTHIAZOLE; CARBON 11; FLUORINE 18; LIGAND; METABOTROPIC RECEPTOR 1; METHYL GROUP; N 4 6 ISOPROPYLAMINO PYRIMIDIN 4 YL 1,3 THIAZOL 2 YL 4 11C METHOXY N METHYLBENZAMIDE; PHENOL; PYRIMIDINE DERIVATIVE; RADIOLIGAND; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN; CEREBELLUM; FUNCTIONAL NEUROIMAGING; MALE; METHYLATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RODENT; SYNTHESIS; THALAMUS;

ANIMALS; AUTORADIOGRAPHY; BENZAMIDES; BRAIN; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; LIGANDS; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TISSUE DISTRIBUTION;

EID: 84863275575     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201590g     Document Type: Article

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