The anti-repressor MecR2 promotes the proteolysis of the mecA repressor and enables optimal expression of β-lactam resistance in MRSA

PLoS Pathogens

Volumn 8, Issue 7, 2012, Pages 13-

  Arêde, Pedro ^a   Milheiriço, Catarina ^b   de Lencastre, Hermínia ^b,c   Oliveira, Duarte C ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; MECR2 PROTEIN; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; UNCLASSIFIED DRUG; BETA LACTAM; MECA PROTEIN, STAPHYLOCOCCUS AUREUS; MECI PROTEIN, STAPHYLOCOCCUS; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PROMOTER REGION; TRANSCRIPTION INITIATION;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PROMOTER REGIONS, GENETIC; PROTEOLYSIS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84872922662     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002816     Document Type: Article

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