The distribution of mecA, mecR1 and mecI and sequence analysis of mecI and the mec promoter region in staphylococci expressing resistance to methicillin

Journal of Antimicrobial Chemotherapy

Volumn 43, Issue 1, 1999, Pages 15-22

  Weller, Timothy M A ^a,b  

^a ABERDEEN ROYAL INFIRMARY   (United Kingdom)

^b CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; METICILLIN; NUCLEOTIDE;

ARTICLE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CODON; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; PENICILLIN RESISTANCE; POLYMERASE CHAIN REACTION; PROMOTER REGION; PULSED FIELD GEL ELECTROPHORESIS; REGULATOR GENE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS HAEMOLYTICUS; STAPHYLOCOCCUS INFECTION; STAPHYLOCOCCUS SIMULANS;

BACTERIAL PROTEINS; BASE SEQUENCE; COAGULASE; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE FREQUENCY; METHICILLIN; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCUS;

EID: 0032922943     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/43.1.15     Document Type: Article

References (22)

1. Chambers, H. F. (1987). Coagulase-negative staphylococci resistant to beta-lactam antibiotics in vivo produce penicillin-binding protein 2a. Antimicrobial Agents and Chemotherapy 31, 1919-24.
2. Hartman, B. J. & Tomasz, A. (1984). Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. Journal of Bacteriology 158, 513-6.
3. Georgopapadakou, N. H., Smith, S. A. & Bonner, D. P. (1982). Penicillin-binding proteins in a Staphylococcus aureus strain resistant to specific beta-lactam antibiotics. Antimicrobial Agents and Chemotherapy 22, 172-5.
4. Brown, D. F. & Reynolds, P. E. (1980). Intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus. FEBS Letters 122, 275-8.
5. Suzuki, E., Hiramatsu, K. & Yokota, T. (1992). Survey of methicillin-resistant clinical strains of coagulase-negative staphylococci for mecA gene distribution. Antimicrobial Agents and Chemotherapy 36, 429-34.
6. Hiramatsu, K., Asada, K., Suzuki, E., Okonogi, K. & Yokota, T. (1992). Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). FEBS Letters 298, 133-6.
7. Tesch, W., Ryffel, C., Strassle, A., Kayser, F. H. & Berger-Bachi, B. (1990). Evidence of a novel staphylococcal mec-encoded element (mecR) controlling expression of penicillin-binding protein 2'. Antimicrobial Agents and Chemotherapy 34, 1703-6.
8. Suzuki, E., Kuwahara-Arai, K., Richardson, J. F. & Hiramatsu, K. (1993). Distribution of mec regulator genes in methicillin-resistant Staphylococcus clinical strains. Antimicrobial Agents and Chemotherapy 37, 1219-26.
9. Hiramatsu, K. (1995). Molecular evolution of MRSA. Microbiology and Immunology 39, 531-43.
10. Kobayashi, N., Taniguchi, K. & Urasawa, S. (1998). Analysis of diversity of mutations in the mecl gene and mecA promoter/ operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Antimicrobial Agents and Chemotherapy 42, 717-20.
11. Boyce, J. M., Medeiros, A. A., Papa, E. F. & O'Gara, C. J. (1990). Induction of beta-lactamase and methicillin resistance in unusual strains of methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy 25, 73-81.
12. Archer, G. L., Niemeyer, D. M., Thanassi, J. A. & Pucci, M. J. (1994). Dissemination among staphylococci of DNA sequences associated with methicillin resistance. Antimicrobial Agents and Chemotherapy 38, 447-54.
13. Milne, L. M., Curtis, G. D., Crow, M., Kraak, W. A. & Selkon, J. B. (1987). Comparison of culture media for detecting methicillin resistance in Staphylococcus aureus and coagulase negative staphylococci. Journal of Clinical Pathology 40, 1178-81.
14. Weller, T. M., Crook, D. W., Crow, M. R., Ibrahim, W., Pennington, T. H. & Selkon, J. B. (1997). Methicillin susceptibility testing of staphylococci by Etest and comparison with agar dilution and mecA detection. Journal of Antimicrobial Chemotherapy 39, 251-3.
15. Tokue, Y., Shoji, S., Satoh, K., Watanabe, A. & Motomiya, M. (1992). Comparison of a polymerase chain reaction assay and a conventional microbiologic method for detection of methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 36, 6-9.
16. Falla, T. J., Crook, D. W., Brophy, L. N., Maskell, D., Kroll, J. S. & Moxon, E. R. (1994). PCR for capsular typing of Haemophilus influenzae. Journal of Clinical Microbiology 32, 2382-6.
17. Berger-Bachi, B., Barberis-Maino, L., Strassle, A. & Kayser, F. H. (1989). FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: molecular cloning and characterization. Molecular and General Genetics 219, 263-9.
18. Song, M. D., Wachi, M., Doi, M., Ishino, F. & Matsuhashi, M. (1987). Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion. FEBS Letters 221, 167-71.
19. Tenover, F. C., Arbeit, R. D., Goering, R. V., Mickelsen, P. A., Murray, B. E., Persing, D. H. et al. (1995). Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. Journal of Clinical Microbiology 33, 2233-9.
20. Kobayashi, N., Taniguchi, K., Kojima, K., Urasawa, S., Uehara, N., Omizu, Y. et al. (1996). Genomic diversity of mec regulator genes in methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Epidemiology and Infection 117, 289-95.
21. Archer, G. L. & Niemeyer, D. M. (1994). Origin and evolution of DNA associated with resistance to methicillin in staphylococci. Trends in Microbiology 2, 343-7.
22. Kobayashi, T., Zhu, Y. F., Nicholls, N. J. & Lampen, J. O. (1987). A second regulatory gene, blaR1, encoding a potential penicillin-binding protein required for induction of beta-lactamase in Bacillus licheniformis. Journal of Bacteriology 169, 3873-8.