The basis for resistance to β-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus

Journal of Biological Chemistry

Volumn 279, Issue 39, 2004, Pages 40802-40806

  Fuda, Cosimo ^a   Suvorov, Maxim ^a   Vakulenko, Sergei B ^a   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; DRUG PRODUCTS; ENZYMES; GENES;

DRUG RESISTANCE; PENICILLINE-BINDING PROTEIN; SERINE RESIDUE;

ANTIBIOTICS;

AMPICILLIN; BETA LACTAM ANTIBIOTIC; CARBAPENEM; CEFEPIME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; IMIPENEM; LINEZOLID; METICILLIN; NITROCEFIN; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN DERIVATIVE;

ACYLATION; ANIMAL CELL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENE; BINDING KINETICS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ESCHERICHIA COLI; EVALUATION; GENE EXPRESSION; IN VIVO STUDY; MECA GENE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; STAPHYLOCOCCUS AUREUS; STRAIN IDENTIFICATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMS; BINDING SITES; CARRIER PROTEINS; CATALYSIS; CELL WALL; CIRCULAR DICHROISM; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; GENETIC VECTORS; HEXOSYLTRANSFERASES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHICILLIN; MODELS, CHEMICAL; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MUTATION; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCUS AUREUS; TIME FACTORS; VARIATION (GENETICS);

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEGIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 4644366894     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403589200     Document Type: Article

References (33)

1. Pinho, M. G., de Lencastre, H., and Tomasz, A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10886-10891
2. Enright, M. C., Robinson, D. A., Randle, G., Feil, E. J., Grundmann, H., and Spratt, B. G. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 7687-7692
3. Georgopapadakou, N. H., Dix, B. A., and Mauriz, Y. R. (1996) Antimicrob. Agents Chemother. 29, 333-336
4. Bush, K., and Mobashery, S. (1998) Adv. Exp. Med. Biol. 456, 71-98
5. Goffin, C., and Ghuysen, J. M. (2002) Microbiol. Mol. Biol. Rev. 66, 702-738
6. Entenza, J. M., Hohl, P., Heinze-Krauss, I., Glausner, M. P., and Moreillon, P., (2002) Antimicrob. Agents Chemother. 46, 171-177
7. Malouin, F., Biais, J., Chamberland, S., Hoang, M., Park, C., Chan, C., Mathias, K, Hakem, S., Dupree, K., Liu, E., Nguyen, T., and Dudley, M. N. (2003) Antimicrob. Agents Chemother. 47, 658-664
8. Ishikawa, T., Matsunaga, N., Tawada, H., Kuroda, N., Nakayama, Y., Ishibashi, Y., Tomimoto, M., Ikeda, Y., Tagawa, Y., Iizawa, Y., Okonogi, K., Hashiguchi, S., and Miyake, A. (2003) Bioorg. Med. Chem. 11, 2427-2437
9. Drew, R. H., Perfect, J. R., Srinath, L., Kurkimilis, E., Dowzicky, M., and Talbot, G. H. (2000) J. Antimicrob. Chemother. 46, 775-784
10. Richter, S. S., Kealey, D. E., Murray, C. T., Heilmann, K. P., Coffman, S. L., and Doern, G. V. (2003) J. Antimicrob. Chemother. 52, 123-127
11. Dailey, C. F., Dileto-Fang, C. L., Buchanan, L. V., Oramas-Shirey, M. P., Batts, D. H., Ford, C. W., and Gibson, J. K. (2001) Antimicrob. Agents Chemother. 45, 2304-2308
12. Tsiodras, S., Gold, H. S., Sakoulas, G., Eliopoulos, G. M., Wennersten, C., Venkataraman, L., Moellering, R. C., and Ferraro, M. J. (2001) Lancet 358, 207-208
13. Bartley, J. (2002) Infect. Control Hasp. Epidemiol. 23, 480
14. Walsh, T. R., Bolmstrom, A., Qwarnstrom, A., Ho, P., Wootton, M., Howe, R. A., MacGowan, A. P., and Diekema, D. (2001) J. Clin. Microbiol. 39, 2439-2444
15. Centers for Disease Control and Prevention (2002) Marb. Mortal. Wkly. Rep. 51, 931
16. Centers for Disease Control and Prevention (2004) Morb. Mortal. Wkly. Rep. 53, 322-323
17. Lim, D., and Strynadka, N. C. (2002) Nat. Struct. Biol. 9, 870-876
18. Graves-Woodward, K., and Pratt, R. F. (1998) Biochem. J. 332, 755-761
19. Zhao, G., Meier, T. I., Kahn, S. D., Gee, K. R., and Blaszczak, L. C. (1999) Antimicrob. Agents Chemother. 43, 1124-1128
20. Roychoudhury, S., Dotzlaf, J. E., Ghag, S., and Yeh, W. (1994) J. Biol. Chem. 269, 12067-12073
21. Sun, Y., Bauer, M. D., and Lu, W. (1998) J. Mass Spectrom. 33, 1009-1016
22. Pinho, M.G., Ludovice, A. M., Wu, S., and De Lencastre, H. (1997) Microb. Drug Resist. 3, 409-413
23. Hackbarth, C. J., Muck, C., and Chambers, H. F. (1994) Antimicrob. Agents Chemother. 38, 2568-2571
24. Katayama, Y., Zhang, H. Z., Hong, D., and Chambers, H. F. (2003) J. Bacteriol. 185, 5465-5472
25. Katayama, Y., Zhang, H. Z., and Chambers, H. F. (2004) Antimicrob. Agents Chemother. 48, 453-459
26. Lu, W. P., Kincaid, E., Sun, Y., and Bauer, M. D. (2001) J. Biol. Chem. 276, 31494-31501
27. Jamin, M., Hakenbeck, R., and Frere, J. M. (1993) FEBS Lett. 331, 101-104
28. Crisostomo, M. I., Westh, H., Tomasz, A., Chung, M., Oliveira, D. C., and de Lencastre, H., (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9865-9870
29. Lu, W. P., Sun, Y., Bauer, M. D., Paule, S., Koenigs, P. M., and Kraft, W. G. (1999) Biochemistry 38, 6537-6546
30. Wu, C. Y., Alborn, W. E., Flokowitsch, J. E., Hoskins, J., Unal, S., Blaszczak, L. C., Preston, D. A., and Skatrud, P. L. (1994) J. Bacteriol. 176, 443-449
31. Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J. P., and Mobashery, S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 14280-14285
32. Golemi-Kotra, D., Cha, J. Y., Meroueh, S. O., Vakulenko, S. B., and Mobashery, S. (2003) J. Biol. Chem. 278, 18419-18425
33. Lee, W., McDonough, M. A., Kotra, L., Li, Z. H., Silvaggi, N. R., Takeda, Y., Kelly, J. A., and Mobashery, S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 1427-1431