Electrophysiological effects of ivabradine in dog and human cardiac preparations: Potential antiarrhythmic actions

European Journal of Pharmacology

Volumn 668, Issue 3, 2011, Pages 419-426

  Koncz, István ^a   Szél, Tamás ^a   Bitay, Miklós ^e   Cerbai, Elisabetta ^c   Jaeger, Kristian ^a   Fülöp, Ferenc ^d   Jost, Norbert ^b   Virág, László ^a   Orvos, Péter ^f   Tálosi, László ^f   Kristóf, Attila ^b   Baczkó, István ^a   Papp, Julius Gy ^a,b   Varró, András ^a,b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITY OF SZEGED   (Hungary)

^e UNIVERSITY OF SZEGED   (Hungary)

^f Rytmion Ltd   (Hungary)

Author keywords

Diastolic depolarization; Human heart; Ivabradine; Purkinje fiber; Repolarization; V max

Indexed keywords

IVABRADINE;

ANIMAL CELL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CARDIOVASCULAR RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; HUMAN TISSUE; IC 50; ION CURRENT; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; BENZAZEPINES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGICAL PROCESSES; HEART; HUMANS; KINETICS; POTASSIUM; RABBITS; SODIUM CHANNEL BLOCKERS;

EID: 80053573168     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.07.025     Document Type: Article

References (23)

1. P. Bois, J. Bescond, B. Renaudon, and J. Lenfant Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells Br. J. Pharmacol. 118 1996 1051 1057 (Pubitemid 26261281)
2. f inhibition with ivabradine: electrophysiological effects and safety Drug Saf. 31 2008 95 107 (Pubitemid 351175614)
3. C.J. Cohen, B.P. Bean, and R.W. Tsien Maximal upstroke velocity as an index of available sodium conductance Circ. Res. 54 1984 636 651
4. f) plays an important role in regulating SA node pacemaker activity Cardiovasc. Res. 30 1995 307 308
5. K. Fox, I. Ford, P.G. Steg, M. Tendera, and R. Ferrari Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial Lancet 372 2008 807 816
6. G. Heusch, A. Skyschally, P. Gres, P. van Caster, D. Schilawa, and R. Schulz Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction Eur. Heart J. 29 2008 2265 2275
7. L.M. Hondeghem, and B.G. Katzung Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs Ann. Rev. Pharmacol. Toxicol. 24 1984 387 423 (Pubitemid 14129541)
8. R. Joannides, N. Moore, M. Iacob, P. Compagnon, G. Lerebours, J.F. Menard, and C. Thuillez Comparative effects of ivabradine, a selective heart rate-lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise Br. J. Clin. Pharmacol. 61 2005 127 137 (Pubitemid 43382606)
9. I. Koncz, T. Szél, K. Jaeger, I. Baczkó, E. Cerbai, M.N. Romanelli, J.Gy. Papp, and A. Varró Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets Curr. Med. Chem. 118 2011 (accepted manuscript)
10. A. Maguy, S. Le Bouter, P. Comtois, D. Chartier, L. Villeneuve, R. Wakili, K. Nishida, and S. Nattel Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure Circ. Res. 104 2009 1113 1122
11. O. Pérez, P. Gay, L. Fanqueza, R. Carrón, C. Valenzuela, E. Delpón, and J. Tamargo Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations Br. J. Pharmacol. 115 1995 787 794
12. + currents in ventricular myocytes from the epicardial border zone of the infarcted heart Circ. Res. 83 1998 431 440 (Pubitemid 28389973)
13. M. Rota, and M. Vassalle Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range J. Physiol. 548 2003 147 165 (Pubitemid 36410805)
14. D.A. Saint The cardiac persistent sodium current: an appealing therapeutic target? Br. J. Pharmacol. 153 2008 1133 1142 (Pubitemid 351415490)
15. Na in canine cardiac purkinje cells Circ. Res. 63 1998 386 398
16. J.C. Tardif, and J.S. Borer Efficacy of ivabradine, a selective I(f) inhibitor, in patients with chronic stable angina pectoris and diabetes mellitus Am. J. Cardiol. 105 2010 29 35
17. f inhibition help in congestive heart failure? Dialogues in Cardiovascular Medicine 11 2006 30 35 (Pubitemid 43810945)
18. C. Thollon, J.P. Bidouard, C. Cambarrat, L. Lesage, H. Reure, I. Delescluse, J. Vian, J.L. Peglion, and J.P. Vilaine Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S16257 Eur. J. Pharmacol. 339 1997 43 51 (Pubitemid 28015430)
19. C. Thollon, C. Cambarrat, J. Vian, J.F. Prost, J.L. Peglion, and J.P. Vilaine Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49 Br. J. Pharmacol. 112 1994 37 42 (Pubitemid 24151700)
20. Ks in dog ventricular muscle and Purkinje fibre repolarization J. Physiol. 523 2000 67 81 (Pubitemid 30135822)
21. M. Vassalle, H. Yu, and I.S. Cohen The pacemaker current in cardiac Purkinje myocytes J. Gen. Physiol. 106 1995 559 578
22. f current inhibitor Eur. Heart J. Supplements 5 2003 26 35
23. L. Virág, A. Varró, and J.Gy. Papp Effect of disopyramide on potassium currents in rabbit ventricular myocytes Naunyn-Schmiedeberg's Arch. Pharmacol. 357 1998 268 275 (Pubitemid 28112576)