A novel antagonist, No. 7943, of the Na+/Ca2+ exchange current in guinea-pig cardiac ventricular cells

British Journal of Pharmacology

Volumn 119, Issue 3, 1996, Pages 555-563

  Watano, Tomokazu ^b   Kimura, Junko ^a   Morita, Tominori ^b   Nakanishi, Hironori ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b KANEBO LTD   (Japan)

Author keywords

3'4' dichlorobenzamil (DCB); Ca2+ current; Cardiac myocyte; Competitive inhibition; Heart; K+ current; Na+ current; Na+ Ca2+ exchange current; No. 7943; Whole cell clamp

Indexed keywords

3',4' DICHLOROBENZAMIL; ANTIPORTER; CALCIUM ION; MESYLIC ACID DERIVATIVE; NO 7943; POTASSIUM ION; SODIUM ION; UNCLASSIFIED DRUG; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; EXTRACELLULAR CALCIUM; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE; MEMBRANE CURRENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT; VOLTAGE CLAMP;

EID: 0029833380     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15708.x     Document Type: Article

References (37)

1. ALLEN, D.G., CAIRNS, S.P., TURVEY, S.E. & LEE, J.A. (1993). Intracellular calcium and myocardial function during ischemia. Adv. Exp. Med. Biol., 346, 19-29.
2. ALLEN, D.G., & ORCHARD, C.H. (1987). Myocardial contractile function during ischemia and hypoxia. Circ. Res., 60, 153-168.
3. BERSOHN, M.M., PHILIPSON, K.D. & WHIS, R.S. (1991). Lysophosphatidylcholine and sodium-calcium exchange in cardiac sarcolemma: comparison with ischemia. Am. J. Physiol., 260, C433-C438.
4. BIELEFELD, D.R., HADLHY, R.W., VASSILEY, P.M. & HUME, J.R. (1986). Membrane electrical properties of vesicular Na-Ca exchange Inhibitors in single atrial myocytes. Circ. Res., 59, 381-389.
5. BLAUSTEIN, M.P. & RUSSELL, J.M. (1975). Sodium-calcium exchange and calcium-calcium exchange in internally dialyzed squid giant axons. J. Membr. Biol., 22, 285-312.
6. CHIN, T.K., SPITZER, K.W., PHILIPSON, K.D. & BRIDGH, J.H.B. (1993). The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells. Circ. Res., 72, 497-503.
7. COETZEE, W.A. & OPIE, L.H. (1987). Effects of components of ischemia and metabolic inhibition on delayed after depolarizations in guinea pig papillary muscle. Circ. Res., 61, 157-165.
8. 2+ exchange activity by quinacrine. Am. J. Physiol., 252, C24-C29.
9. DENNIS, S.C., GEVERS, W. & OPIE, L.H. (1991). Protons in ischemia: where do they come from; where do they go to? J. Mol. Cell. Cardiol., 23, 1077-1086.
10. + concentration. J. Biol. Chem., 259, 8880-8885.
11. GARCIA, M.L., SLAUGHTER, R.S., KING, V.F. & KACZOROWSKI, G.J. (1988). Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 2. Mechanisms of inhibition by bepridil. Biochemistry, 27, 2410-2415.
12. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflügers Arch., 391, 85-100.
13. 2+ exchange in pituitary plasma membrane vesicles by analogues of amiloride. Biochemistry, 24, 1394-1403.
14. KACZOROWSKI, G.J., GARCIA, M.L., KING, R. & SLAUGHTER, R.S. (1989). Development and use of inhibitors to study sodium-calcium exchange. In Sodium-Calcium Exchange, ed. Allen, F.J., Noble, D., & Reuter, H., pp. 66-101. Oxford: University Press.
15. 2+ exchange system. J. Biol. Chem., 266, 13764-13769.
16. 2+ exchange current in guinea-pig cardiac myocytes. Ann. N. Y. Acad. Sci., 119, 515-520.
17. KIMURA, J., MIYAMAE, S. & NOMA, A. (1987). Identification of sodium-calcium exchange current in single ventricular cells of guinea-pig. J. Physiol., 384, 199-222.
18. KLEYMAN, T.R. & CRAGOE, E.J. Jr. (1988). Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol., 105, 1-21.
19. KUSUOKA, H., CAMILION DE HURATADA, M.C. & MARBAN, E. (1993). Role of Sodium/Calcium exchange in the mechanisms of myocardial stunning: Protective effect of reperfusion with high sodium solution. J. Am. Coll. Cardiol., 21, 240-248.
20. NIGGLI, E., & LEDERER, W.J. (1991). Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature, 349, 621-624.
21. LI, J.M. & KIMURA, J. (1991). Translocation mechanism of cardiac Na-Ca exchange. Ann. N. Y. Acad. Sci., 639, 48-60.
22. 2+ exchanger. J. Biol. Chem., 266, 1014-1020.
23. 2+. J. Gen. Physiol., 93, 1129-1145.
24. MURATA, Y., HARADA, K., NAKAJIMA, F., MARUO, J. & MORITA, T. (1995). Non-selective effects of amiloride and its analogues on ion transport systems and their cytotoxicities in cardiac myocytes. Jpn. J. Pharmacol., 68, 279-285.
25. 2+ exchanger. Science, 250, 562-565.
26. NIGGLI, E. & LEDERER, W.J. (1991). Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature, 349, 621-624.
27. 2+ exchange in cardiac sarcolemmal vesicles. J. Biol. Chem., 259, 13999-14002.
28. POOLE-WILSON, P.A. (1989). Regulation of intracellular pH in the myocardium; relevance to pathology. Mol. Cell Biochem., 89, 151-155.
29. REEVES, J.P. & SUTKO, J.L. (1983). Competitive interactions of sodium and calcium with the sodium-calcium exchange system of cardiac sarcolemmal vesicles. J. Biol. Chem., 258, 3178-3182.
30. + exchange inhibitor and its effects in cardiac ischemia. Br. J. Pharmacol., 109, 562-568.
31. 2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride. Proc. Natl. Acad. Sci. U.S.A., 81, 3238-3242.
32. SLAUGHTER, R.S., GARCIA, M.L., CRAGOE, E.J.Jr., REEVES, J.P. & KACZOROWSKI, G.J. (1988). Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 1. Mechanism of inhibition by amiloride analogues. Biochemistry, 27, 2403-2409.
33. STEENBERGEN, C., DELEEUW, G., RICH, T. & WILLIAMSON, J.R. (1977). Effects of acidosis and ischemia on contractility and intracellular pH of rat heart. Circ. Res., 41, 849-858.
34. 3 pituitary cells. J. Pharmacol. Exp. Ther., 247, 248-253.
35. 2+ exchange in cardiac sarcolemmal vesicles. Biochem. Biophys. Acta., 731, 63-68.
36. VER DONCK, L., MARCEL, B. & VERDONCK, F. (1993). Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle. Cardiovasc. Res., 27, 349-357.
37. WRIGHT, A.R., REES, S.A., VANDENVERG, J.I., TEIST, V.W. & POWELL, T. (1995) Extracellular osmotic pressure modulated sodium-calcium exchange in isolated guinea-pig ventricular myocytes. J. Physiol., 488, 293-301.