-
1
-
-
77649123846
-
The role of the funny current in pacemaker activity
-
DiFrancesco D. The role of the funny current in pacemaker activity. Circ Res. 2010;106:434-446.
-
(2010)
Circ Res.
, vol.106
, pp. 434-446
-
-
DiFrancesco, D.1
-
2
-
-
36148965480
-
The funny current: Cellular basis for the control of heart rate
-
DiFrancesco D, Borer JS. The funny current: cellular basis for the control of heart rate. Drugs. 2007;67:15-24. (Pubitemid 350114592)
-
(2007)
Drugs
, vol.67
, Issue.SUPPL. 2
, pp. 15-24
-
-
DiFrancesco, D.1
Borer, J.S.2
-
3
-
-
67649104033
-
What keeps us ticking: A funny current, a calcium clock or both?
-
Lakatta EG, DiFrancesco D. What keeps us ticking: a funny current, a calcium clock, or both? J Mol Cell Cardiol. 2009;47:157-170.
-
(2009)
J Mol Cell Cardiol.
, vol.47
, pp. 157-170
-
-
Lakatta, E.G.1
DiFrancesco, D.2
-
4
-
-
77949379471
-
2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker
-
2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res. 2010; 106:659-673.
-
(2010)
Circ Res.
, vol.106
, pp. 659-673
-
-
Lakatta, E.G.1
Maltsev, V.A.2
Vinogradova, T.M.3
-
5
-
-
38849146377
-
2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function
-
DOI 10.1093/cvr/cvm058
-
2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function. Cardiovasc Res. 2008;77: 274-284. (Pubitemid 351197645)
-
(2008)
Cardiovascular Research
, vol.77
, Issue.2
, pp. 274-284
-
-
Maltsev, V.A.1
Lakatta, E.G.2
-
7
-
-
47249125756
-
(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells
-
(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells. J Biol Chem. 2008;283:14461-14468.
-
(2008)
J Biol Chem.
, vol.283
, pp. 14461-14468
-
-
Younes, A.1
Lyashkov, A.E.2
Graham, D.3
Sheydina, A.4
Volkova, M.V.5
Mitsak, M.6
Vinogradova, T.M.7
Lukyanenko, Y.O.8
Li, Y.9
Ruknudin, A.M.10
Boheler, K.R.11
Van Eyk, J.12
Lakatta, E.G.13
-
8
-
-
74149088545
-
Beta-adrenergic receptor signaling in the heart: Role of CaMKII
-
Grimm M, Brown JH. Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol. 2010;48:322-330.
-
(2010)
J Mol Cell Cardiol.
, vol.48
, pp. 322-330
-
-
Grimm, M.1
Brown, J.H.2
-
9
-
-
65249100171
-
Calmodulin kinase II is required for fight or flight sinoatrial node physiology
-
Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009;106:5972-5977.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, pp. 5972-5977
-
-
Wu, Y.1
Gao, Z.2
Chen, B.3
Koval, O.M.4
Singh, M.V.5
Guan, X.6
Hund, T.J.7
Kutschke, W.8
Sarma, S.9
Grumbach, I.M.10
Wehrens, X.H.11
Mohler, P.J.12
Song, L.S.13
Anderson, M.E.14
-
10
-
-
0006006081
-
The heart rate of the sympathectomized dog in rest and exercise
-
Brouha L, Cannon WB, Dill DB. The heart rate of the sympathectomized dog in rest and exercise. J Physiol. 1936;87:345-359.
-
(1936)
J Physiol.
, vol.87
, pp. 345-359
-
-
Brouha, L.1
Cannon, W.B.2
Dill, D.B.3
-
11
-
-
82955239542
-
Pharmacological injections and physiological inferences
-
Cannon WB. Pharmacological injections and physiological inferences. Science. 1929;70:500-501.
-
(1929)
Science
, vol.70
, pp. 500-501
-
-
Cannon, W.B.1
-
12
-
-
77953358632
-
(2+) release both contribute to pacemaker activity in canine sinoatrial node cells
-
(2+) release both contribute to pacemaker activity in canine sinoatrial node cells. J Mol Cell Cardiol. 2010;49:33-40.
-
(2010)
J Mol Cell Cardiol.
, vol.49
, pp. 33-40
-
-
Gao, Z.1
Chen, B.2
Joiner, M.L.3
Wu, Y.4
Guan, X.5
Koval, O.M.6
Chaudhary, A.K.7
Cunha, S.R.8
Mohler, P.J.9
Martins, J.B.10
Song, L.S.11
Anderson, M.E.12
-
15
-
-
20244362095
-
Calmodulin kinase II inhibition protects against structural heart disease
-
DOI 10.1038/nm1215
-
Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE Jr, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med. 2005;11:409-417. (Pubitemid 40562331)
-
(2005)
Nature Medicine
, vol.11
, Issue.4
, pp. 409-417
-
-
Zhang, R.1
Khoo, M.S.C.2
Wu, Y.3
Yang, Y.4
Grueter, C.E.5
Ni, G.6
Price Jr., E.E.7
Thiel, W.8
Guatimosim, S.9
Song, L.-S.10
Madu, E.C.11
Shah, A.N.12
Vishnivetskaya, T.A.13
Atkinson, J.B.14
Gurevich, V.V.15
Salama, G.16
Lederer, W.J.17
Colbran, R.J.18
Anderson, M.E.19
-
16
-
-
0014444074
-
The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres
-
Hauswirth O, Noble D, Tsien RW. The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres. J Physiol. 1969; 200:255-265.
-
(1969)
J Physiol.
, vol.200
, pp. 255-265
-
-
Hauswirth, O.1
Noble, D.2
Tsien, R.W.3
-
17
-
-
69249150907
-
(2+) cycling and I(KACh)
-
(2+) cycling and I(KACh). Am J Physiol Heart Circ Physiol. 2009;297:H949-H959.
-
(2009)
Am J Physiol Heart Circ Physiol.
, vol.297
-
-
Lyashkov, A.E.1
Vinogradova, T.M.2
Zahanich, I.3
Li, Y.4
Younes, A.5
Nuss, H.B.6
Spurgeon, H.A.7
Maltsev, V.A.8
Lakatta, E.G.9
-
19
-
-
0025782740
-
Direct activation of cardiac pacemaker channels by intracellular cyclic AMP
-
DiFrancesco D, Tortora P. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature. 1991;351:145-147. (Pubitemid 21896552)
-
(1991)
Nature
, vol.351
, Issue.6322
, pp. 145-147
-
-
DiFrancesco, D.1
Tortora, P.2
-
20
-
-
77956236012
-
Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node
-
Liao Z, Lockhead D, Larson ED, Proenza C. Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node. J Gen Physiol. 2010;136:247-258.
-
(2010)
J Gen Physiol.
, vol.136
, pp. 247-258
-
-
Liao, Z.1
Lockhead, D.2
Larson, E.D.3
Proenza, C.4
-
21
-
-
0034623718
-
16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to β-agonists
-
DOI 10.1074/jbc.M004079200
-
Chu G, Lester JW, Young KB, Luo W, Zhai J, Kranias EG. A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta-agonists. J Biol Chem. 2000;275: 38938-38943. (Pubitemid 32009233)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.49
, pp. 38938-38943
-
-
Chu, G.1
Lester, J.W.2
Young, K.B.3
Luo, W.4
Zhai, J.5
Kranias, E.G.6
-
22
-
-
0022921924
-
Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains
-
Simmerman HK, Collins JH, Theibert JL, Wegener AD, Jones LR. Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains. J Biol Chem. 1986;261: 13333-13341. (Pubitemid 17006915)
-
(1986)
Journal of Biological Chemistry
, vol.261
, Issue.28
, pp. 13333-13341
-
-
Simmerman, H.K.B.1
Collins, J.H.2
Theibert, J.L.3
-
23
-
-
0141653536
-
2+ release contributes to automaticity in cat atrial pacemaker cells
-
2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol. 2000;524:415-422. (Pubitemid 30229507)
-
(2000)
Journal of Physiology
, vol.524
, Issue.2
, pp. 415-422
-
-
Huser, J.1
Blatter, L.A.2
Lipsius, S.L.3
-
25
-
-
42049095908
-
2+ releases
-
DOI 10.1161/CIRCRESAHA.107.161679
-
2+ releases. Circ Res. 2008;102:761-769. (Pubitemid 351521586)
-
(2008)
Circulation Research
, vol.102
, Issue.7
, pp. 761-769
-
-
Vinogradova, T.M.1
Sirenko, S.2
Lyashkov, A.E.3
Younes, A.4
Li, Y.5
Zhu, W.6
Yang, D.7
Ruknudin, A.M.8
Spurgeon, H.9
Lakatta, E.G.10
-
26
-
-
0037059563
-
2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells
-
DOI 10.1161/hh0102.102271
-
(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res. 2002;90:73-79. (Pubitemid 34074611)
-
(2002)
Circulation Research
, vol.90
, Issue.1
, pp. 73-79
-
-
Vinogradova, T.M.1
Bogdanov, K.Yu.2
Lakatta, E.G.3
-
27
-
-
0032498172
-
2+ oscillations
-
DOI 10.1126/science.279.5348.227
-
2+ oscillations. Science. 1998;279:227-230. (Pubitemid 28103880)
-
(1998)
Science
, vol.279
, Issue.5348
, pp. 227-230
-
-
De Koninck, P.1
Schulman, H.2
-
29
-
-
0032508040
-
A family of hyperpolarization-activated mammalian cation channels
-
DOI 10.1038/31255
-
Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. A family of hyperpolarization-activated mammalian cation channels. Nature. 1998; 393:587-591. (Pubitemid 28319249)
-
(1998)
Nature
, vol.393
, Issue.6685
, pp. 587-591
-
-
Ludwig, A.1
Zong, X.2
Jeglitsch, M.3
Hofmann, F.4
Biel, M.5
-
30
-
-
30444452695
-
Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel
-
DOI 10.1056/NEJMoa052475
-
Milanesi R, Baruscotti M, Gnecchi-Ruscone T, Difrancesco D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N Engl J Med. 2006;354:151-157. (Pubitemid 43076712)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.2
, pp. 151-157
-
-
Milanesi, R.1
Baruscotti, M.2
Gnecchi-Ruscone, T.3
DiFrancesco, D.4
-
31
-
-
77956612624
-
Ivabradine and outcomes in chronic heart failure (SHIFT): A randomised placebo-controlled study
-
Swedberg K, Komajda M, Bohm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet. 2010;376: 875-885.
-
(2010)
Lancet
, vol.376
, pp. 875-885
-
-
Swedberg, K.1
Komajda, M.2
Bohm, M.3
Borer, J.S.4
Ford, I.5
Dubost-Brama, A.6
Lerebours, G.7
Tavazzi, L.8
-
32
-
-
0033538398
-
Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues
-
Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D, Cohen IS. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res. 1999;85:e1-e6.
-
(1999)
Circ Res.
, vol.85
-
-
Shi, W.1
Wymore, R.2
Yu, H.3
Wu, J.4
Wymore, R.T.5
Pan, Z.6
Robinson, R.B.7
Dixon, J.E.8
McKinnon, D.9
Cohen, I.S.10
-
33
-
-
35648939866
-
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice
-
DOI 10.1038/sj.emboj.7601868, PII 7601868
-
Herrmann S, Stieber J, Stockl G, Hofmann F, Ludwig A. HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J. 2007;26:4423-4432. (Pubitemid 350036626)
-
(2007)
EMBO Journal
, vol.26
, Issue.21
, pp. 4423-4432
-
-
Herrmann, S.1
Stieber, J.2
Stockl, G.3
Hofmann, F.4
Ludwig, A.5
-
34
-
-
34848845270
-
Normal Heart Rhythm is Initiated and Regulated by an Intracellular Calcium Clock Within Pacemaker Cells
-
DOI 10.1016/j.hlc.2007.07.005, PII S1443950607008438, Pacemaker Cell and Atrial Function
-
Maltsev VA, Lakatta EG. Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells. Heart Lung Circ. 2007;16:335-348. (Pubitemid 47504909)
-
(2007)
Heart Lung and Circulation
, vol.16
, Issue.5
, pp. 335-348
-
-
Maltsev, V.A.1
Lakatta, E.G.2
-
35
-
-
0037307568
-
f) by calcium and calmodulin in the guinea-pig sino-atrial node
-
DOI 10.1016/S0008-6363(02)00668-5, PII S0008636302006685
-
Rigg L, Mattick PA, Heath BM, Terrar DA. Modulation of the hyperpolarization-activated current (If) by calcium and calmodulin in the guinea-pig sino-atrial node. Cardiovasc Res. 2003;57:497-504. (Pubitemid 36149753)
-
(2003)
Cardiovascular Research
, vol.57
, Issue.2
, pp. 497-504
-
-
Rigg, L.1
Mattick, P.A.D.2
Heath, B.M.3
Terrar, D.A.4
-
36
-
-
33645324479
-
2+ store oscillations and spontaneous beating of cardiac pacemaker cells
-
2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res. 2006;98:505-514.
-
(2006)
Circ Res.
, vol.98
, pp. 505-514
-
-
Vinogradova, T.M.1
Lyashkov, A.E.2
Zhu, W.3
Ruknudin, A.M.4
Sirenko, S.5
Yang, D.6
Deo, S.7
Barlow, M.8
Johnson, S.9
Caffrey, J.L.10
Zhou, Y.Y.11
Xiao, R.P.12
Cheng, H.13
Stern, M.D.14
Maltsev, V.A.15
Lakatta, E.G.16
-
38
-
-
33747881612
-
2+ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII
-
DOI 10.1016/j.molcel.2006.07.006, PII S1097276506004837
-
2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Mol Cell. 2006;23:641-650. (Pubitemid 44292555)
-
(2006)
Molecular Cell
, vol.23
, Issue.5
, pp. 641-650
-
-
Grueter, C.E.1
Abiria, S.A.2
Dzhura, I.3
Wu, Y.4
Ham, A.-J.L.5
Mohler, P.J.6
Anderson, M.E.7
Colbran, R.J.8
-
39
-
-
0021182780
-
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
-
Hess P, Lansman JB, Tsien RW. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature. 1984;311:538-544. (Pubitemid 14046377)
-
(1984)
Nature
, vol.311
, Issue.5986
, pp. 538-544
-
-
Hess, P.1
Lansman, J.B.2
Tsien, R.W.3
-
40
-
-
61949338001
-
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
-
Bellinger AM, Reiken S, Carlson C, Mongillo M, Liu X, Rothman L, Matecki S, Lacampagne A, Marks AR. Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med. 2009;15:325-330.
-
(2009)
Nat Med.
, vol.15
, pp. 325-330
-
-
Bellinger, A.M.1
Reiken, S.2
Carlson, C.3
Mongillo, M.4
Liu, X.5
Rothman, L.6
Matecki, S.7
Lacampagne, A.8
Marks, A.R.9
-
41
-
-
77953418093
-
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure
-
Kushnir A, Shan J, Betzenhauser MJ, Reiken S, Marks AR. Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A. 2010;107:10274-10279.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 10274-10279
-
-
Kushnir, A.1
Shan, J.2
Betzenhauser, M.J.3
Reiken, S.4
Marks, A.R.5
|