Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo

Journal of Sexual Medicine

Volumn 7, Issue 4 PART 1, 2010, Pages 1518-1528

  Shindel, Alan W ^a   Xin, Zhong Chen ^b   Lin, Guiting ^a   Fandel, Thomas M ^a   Huang, Yun Ching ^a   Banie, Lia ^a   Breyer, Benjamin N ^a   Garcia, Maurice M ^a   Lin, Ching Shwun ^a   Lue, Tom F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Cavernous Nerve Injury; Complementary Medicine; Erectile Dysfunction; Icariin; Neurotrophins; Testosterone

Indexed keywords

ALCOHOL; CALPONIN; DIMETHYL SULFOXIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIMEDIUM BREVICORNUM EXTRACT; EPIMEDIUM EXTRACT; EPIMEDIUM KOREANUM EXTRACT; EPIMEDIUM SAGITTATUM EXTRACT; ICARIIN; LUTEINIZING HORMONE; NEURONAL NITRIC OXIDE SYNTHASE; PLACEBO; SILDENAFIL; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAVERNOUS NERVE INJURY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG ISOLATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIMEDIUM; EPIMEDIUM BREVICORNUM; EPIMEDIUM KOREANUM; EPIMEDIUM SAGITTATUM; GANGLION; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACAVERNOUS PRESSURE; LOW DRUG DOSE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; NERVE FIBER GROWTH; NERVE STIMULATION; NEUROTROPISM; NONHUMAN; PENILE BLOOD FLOW; PENIS ERECTION; PERIPHERAL NERVE INJURY; PRESSURE AND TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; TESTOSTERONE BLOOD LEVEL; WESTERN BLOTTING;

EID: 77955233813     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01699.x     Document Type: Article

References (25)

1. Xin ZC, Kim E, Tian ZJ, Ling GT, Guo YL. Icariin on relaxation effect of corpus cavernosum smooth muscle. Chin Sci Bull 2001, 46:1186-90.
2. Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology 2006, 68:1350-4.
3. Dell'Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod 2008, 71:1513-7.
4. Zhang ZB, Yang QT. The testosterone mimetic properties of icariin. Asian J Androl 2006, 8:601-5.
5. Wang YK, Huang ZQ. Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro. Pharmacol Res 2005, 52:174-82.
6. Xu HB, Huang ZQ. Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascul Pharmacol 2007, 47:18-24.
7. Tian L, Xin ZC, Yuan YM, Fu J, Liu WJ, Wang LL. Effects of icariin on intracavernosal pressure and systematic arterial blood pressure of rat. Zhonghua Yi Xue Za Zhi 2004, 84:142-5.
8. Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J Androl 2005, 7:381-8.
9. Tian L, Xin ZC, Liu WJ, Yang YM, Liu G, Chen L, Fu J, Wang LL. Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernosum of arterigenic erectile dysfunction rat model. Zhonghua Yi Xue Za Zhi 2004, 84:954-7.
10. Montorsi F, Brock G, Lee J, Shapiro J, Van Poppel H, Graefen M, Stief C. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy. Eur Urol 2008, 54:924-31.
11. Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl 2003, 5:15-8.
12. Bella AJ, Hayashi N, Carrion RE, Price R, Lue TF. FK1706 enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat. J Sex Med 2007, 4:341-6. discussion 46-7
13. Lin G, Chen KC, Hsieh PS, Yeh CH, Lue TF, Lin CS. Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia. BJU Int 2003, 92:631-5.
14. Vignozzi L, Filippi S, Morelli A, Marini M, Chavalmane A, Fibbi B, Silvestrini E, Mancina R, Carini M, Vannelli GB, Forti G, Maggi M. Cavernous neurotomy in the rat is associated with the onset of an overt condition of hypogonadism. J Sex Med 2009, 6:1270-83.
15. Yin XX, Chen ZQ, Liu ZJ, Ma QJ, Dang GT. Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2. Chin Med J (Engl) 2007, 120:204-10.
16. Song YH, Li BS, Chen XM, Cai H. Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. Int J Mol Med 2008, 21:117-24.
17. Nian H, Ma MH, Nian SS, Xu LL. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 2009, 16:320-6.
18. Wang L, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur J Pharmacol 2009, 609:40-4.
19. Makarova MN, Pozharitskaya ON, Shikov AN, Tesakova SV, Makarov VG, Tikhonov VP. Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats. J Ethnopharmacol 2007, 114:412-6.
20. Liu J, Lou YJ. Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: Rat pharmacokinetic studies after administration of icariin. J Pharm Biomed Anal 2004, 36:365-70.
21. Mulhall JP, Muller A, Donohue JF, Mullerad M, Kobylarz K, Paduch DA, Tal R, Li PS, Cohen-Gould L, Scardino PT. The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate. J Sex Med 2008, 5:1126-36.
22. Mulhall JP, Muller A, Donohue JF, Golijanin D, Tal R, Akin-Olugbade Y, Kobylarz K, Cohen-Gould L, Bennett NE, Scardino P. FK506 and erectile function preservation in the cavernous nerve injury model: Optimal dosing and timing. J Sex Med 2008, 5:1334-44.
23. Fandel TM, Bella AJ, Lin G, Tantiwongse K, Lin CS, Pohl J, Lue TF. Intracavernous growth differentiation factor-5 therapy enhances the recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 2008, 5:1866-75.
24. User HM, Hairston JH, Zelner DJ, McKenna KE, McVary KT. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 2003, 169:1175-9.
25. Teloken P, Mesquita G, Montorsi F, Mulhall J. Post-radical prostatectomy pharmacological penile rehabilitation: Practice patterns among the international society for sexual medicine practitioners. J Sex Med 2009, 6:2032-8.