LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 45, Issue 4, 2007, Pages 667-672

  Xu, Wen ^a   Zhang, Yaping ^b   Yang, Ming ^b   Shen, Ziyin ^c   Zhang, Xinmin ^c   Zhang, Weidong ^a,d   Li, Haiyun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c FUDAN UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Icariin; Icariside I; Icariside II; LC MS MS; Pharmacokinetics

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONITRILE; DAIDZEIN; DRUG METABOLITE; FORMIC ACID; ICARIIN; ICARISIDE I; ICARISIDE II; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; EPIMEDIUM; FLAVONES; FLAVONOIDS; ISOFLAVONES; MALE; MEDICINE, CHINESE TRADITIONAL; RATS; RATS, WISTAR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; UMBELLIFERONES;

EID: 35548960004     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.07.007     Document Type: Article

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