Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunction

BJU International

Volumn 103, Issue 10, 2009, Pages 1396-1404

  Kovanecz, Istvan ^a,b   Nolazco, Gaby ^a,c   Ferrini, Monica G ^c   Toblli, Jorge E ^d   Heydarkhan, Sanaz ^a   Vernet, Dolores ^a,c   Rajfer, Jacob ^a,b   Gonzalez Cadavid, Nestor F ^a,b,c,e  

^a UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Erectile dysfunction; Fibroblasts; Myofibroblasts; Type 2 diabetes

Indexed keywords

COLLAGEN; CYCLINE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ERECTILE DYSFUNCTION; FIBROBLAST; HYPERGLYCEMIA; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INTIMA; MALE; MYOFIBROBLAST; NICK END LABELING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PENIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SMOOTH MUSCLE FIBER; TUNICA MEDIA; WESTERN BLOTTING; ZUCKER RAT; ANIMAL; FIBROSIS; ORGANIC IMPOTENCE; PATHOLOGY; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ANIMALS; AORTA; BLOTTING, WESTERN; DIABETES MELLITUS, TYPE 2; FIBROBLASTS; FIBROSIS; IMMUNOHISTOCHEMISTRY; IMPOTENCE, VASCULOGENIC; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PENIS; RATS; RATS, ZUCKER; TUNICA MEDIA;

EID: 66149122264     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.08251.x     Document Type: Article

References (50)

1. Nehra A, Azadzoi KM, Moreland RB et al. Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction. J Urol 1998 159 : 2229 36
2. Burchardt T, Burchardt M, Karden J et al. Reduction of endothelial and smooth muscle density in the corpora cavernosa of the streptozotocin induced diabetic rat. J Urol 2000 164 : 1807 11
3. Ferrini M, Magee TR, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Aging-related expression of inducible nitric oxide synthase (iNOS) and markers of tissue damage in the rat penis. Biol Reprod 2001 64 : 974 82
4. Shen ZJ, Jin XD, Chen ZD, Shi YH. Effect of aging on penile ultrastructure. Asian J Androl 2001 3 : 281 4
5. Simopoulos DN, Gibbons SJ, Malysz J et al. Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation. J Urol 2001 165 : 1776 82
6. Wespes E. Smooth muscle pathology and erectile dysfunction. Int J Impot Res 2002 14 (Suppl. 1 S17 21
7. Podlasek CA, Zelner DJ, Harris JD et al. Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod 2003 69 : 816 27
8. User HM, Hairston JH, Zelner DJ, McKenna KE, McVary KT. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 2003 169 : 1175 9
9. Gonzalez-Cadavid NF, Rajfer J. Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exptl Gerontol 2004 39 : 1705 12
10. Davila HH, Ferrini MG, Magee TR, Rajfer J, Gonzalez-Cadavid NF. Detrimental effect of cigarette smoking on erectile dysfunction in the rat is contingent to diabetes as co-morbidity. J Urol 2004 171 : 374
11. Iacono F, Giannella R, Somma P, Manno G, Fusco F, Mirone V. Histological alterations in cavernous tissue after radical prostatectomy. J Urol 2005 173 : 1673 6
12. Ahn GJ, Sohn YS, Kang KK et al. The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats. Int J Impot Res 2005 17 : 134 41
13. Ferrini MG, Davila H, Kovanecz I, Sanchez S, Gonzalez-Cadavid NF, Rajfer J. Long-term continuous treatment with vardenafil prevents fibrosis and preserves smooth muscle content in the rat corpora cavernosa after bilateral cavernosal nerve transection. Urology 2006 68 : 429 35
14. Kovanecz I, Ferrini MG, Davila HH, Rajfer J, Gonzalez-Cadavid NF. Pioglitazone ameliorates penile corpora veno-occlusive dysfunction in the aged rat. BJU Int 2007 100 : 867 74
15. Ferrini MG, Kovanecz I, Sanchez S et al. Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis. Biol Reprod 2007 76 : 915 23
16. Schwartz EJ, Wong P, Graydon RJ. Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 2004 171 : 771 4
17. Luo H, Goldstein I, Udelson D. A three-dimensional theoretical model of the relationship between cavernosal expandability and percent cavernosal smooth muscle. J Sex Med 2007 4 : 644 5
18. Rajfer J, Rosciszewski A, Mehringer M. Prevalence of corporal venous leakage in impotent men. J Urol 1988 140 : 69 71
19. Metro MJ, Broderick GA. Diabetes and vascular impotence: does insulin dependence increase the relative severity? Int J Impot Res 1999 11 : 87 9
20. Nehra A, Goldstein I, Pabby A et al. Mechanisms of venous leakage: a prospective clinicopathological correlation of corporeal function and structure. J Urol 1996 156 : 1320 9
21. Lue TF. Veno-occlusive dysfunction of corpora cavernosa: comparison of diagnostic methods. J Urol 1996 155 : 786 7
22. Wang YX, Fitch RM. Vascular stiffness: measurements, mechanisms and implications. Curr Vasc Pharmacol 2004 2 : 379 84
23. Najjar SS, Scuteri A, Lakatta EG. Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 2005 46 : 454 62
24. Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens 2003 21 : 3 12
25. Díez J. Arterial stiffness and extracellular matrix. Adv Cardiol 2007 44 : 76 95
26. Izzo JL Mitchell GF. Aging and arterial structure-function relations. Adv Cardiol 2007 44 : 19 34
27. Ferrini MG, Davila H, Valente EG, Gonzalez-Cadavid NF, Rajfer J. Aging-related induction of inducible nitric oxide synthase (iNOS) is vasculo-protective in the arterial media. Cardiovasc Res 2004 61 : 796 805
28. Yasmin, O'Shaughnessy KM. Genetics of arterial structure and function: towards new biomarkers for aortic stiffness? Clin Sci (Lond) 2008 114 : 661 77
29. Cernes R, Zimlichman R, Shargorodsky M. Arterial elasticity in cardiovascular disease: focus on hypertension, metabolic syndrome and diabetes. Adv Cardiol 2008 45 : 65 81
30. Busija DW, Miller AW, Katakam P, Erdös B. Insulin resistance and associated dysfunction of resistance vessels and arterial hypertension. Minerva Med 2005 96 : 223 32
31. Hayden MR, Sowers JR, Tyagi SC. The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded. Cardiovasc Diabetol 2005 4 : 9
32. Izzard AS, Rizzoni D, Agabiti-Rosei E, Heagerty AM. Small artery structure and hypertension: adaptive changes and target organ damage. J Hypertens 2005 23 : 247 50
33. Prieto D. Physiological regulation of penile arteries and veins. Int J Impot Res 2008 20 : 17 29
34. Barra S, Iacono F. Echo-Doppler-flowmetric assessment of penile dorsal arteries and their role in the erectile mechanism. Eur J Radiol 1997 25 : 67 73
35. Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus. BJU Int 2006 98 : 116 24
36. Luttrell IP, Swee M, Starcher B, Parks WC, Chitaley K. Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix. Am J Physiol Heart Circ Physiol 2008 294 : H2204 11
37. Gonzalez-Cadavid NF, Ryndin I, Vernet D, Magee TR, Rajfer J. Presence of NMDA receptor subunits in the male lower urogenital tract. J Androl 2000 21 : 566 78
38. Toblli JE, DeRosa G, Cao G, Piorno P, Pagano P. ACE inhibitor and angiotensin type I receptor antagonist in combination reduce renal damage in obese Zucker rats. Kidney Int 2004 65 : 2343 59
39. Kovanecz I, Rambhatla A, Ferrini MG et al. Long term sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats. Int J Impot Res 2007 100 : 867 74
40. Kovanecz I, Rambhatla A, Ferrini MG et al. Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection. BJU Int 2008 101 : 203 10
41. Ferrini MG, Nolazco G, Vernet D, Gonzalez-Cadavid NF, Berman J. Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis. Fertil Steril 2006 86 (Suppl. 4 1152 63
42. Nolazco G, Kovanecz I, Vernet D et al. Effect of muscle derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int 2008 101 : 1156 64
43. Zhao X, Li LY. PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular hypertrophy in Zucker diabetic fatty rats. Am J Nephrol 2008 28 : 598 606
44. Mitra AK, Del Core MG, Agrawal DK. Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies. Can J Physiol Pharmacol 2005 83 : 701 15
45. Noma T, Mizushige K, Yao L et al. Alteration in aortic wall stiffness and accumulation of collagen during the prediabetic stage of type II diabetes mellitus in rats. Jpn Circ J 1999 63 : 988 93
46. Mizushige K, Noma T, Yao L et al. Effects of troglitazone on collagen accumulation and distensibility of aortic wall in prestage of non-insulin-dependent diabetes mellitus of Otsuka Long-Evans Tokushima Fatty rats. J Cardiovasc Pharmacol 2000 35 : 150 5
47. Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 2001 38 : 581 7
48. Miner MM, Kuritzky L. Erectile dysfunction: a sentinel marker for cardiovascular disease in primary care. Cleve Clin J Med 2007 74 (Suppl. 3 S30 7
49. Babu PV, Sabitha KE, Shyamaladevi CS. Therapeutic effect of green tea extract on advanced glycation and cross-linking of collagen in the aorta of streptozotocin diabetic rats. Clin Exp Pharmacol Physiol 2006 33 : 351 7
50. Susic D, Varagic J, Ahn J, Frohlich ED. Collagen cross-link breakers: a beginning of a new era in the treatment of cardiovascular changes associated with aging, diabetes, and hypertension. Curr Drug Targets Cardiovasc Haematol Disord 2004 4 : 97 101