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Volumn 29, Issue 3, 2013, Pages 1140-1146

Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration

Author keywords

Axonal regeneration; Retinal ganglion cells; RhoA Rho associated kinase; Y 39983

Indexed keywords

4 (AMINOETHYL) N (1H PYRROLO[2,3 B]PYRIDINE 4 YL)BENZAMIDE; RHO KINASE; RHO KINASE 1; RHO KINASE 2; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; Y 39983;

EID: 84872800686     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2205     Document Type: Article
Times cited : (21)

References (32)
  • 1
    • 0027232466 scopus 로고
    • Injury-associated induction of GAP-43 expression displays axon branch specificity in rat dorsal root ganglion neurons
    • Schreyer DJ and Skene JH: Injury-associated induction of GAP-43 expression displays axon branch specificity in rat dorsal root ganglion neurons. J Neurobiol 24: 959-970, 1993. (Pubitemid 23178785)
    • (1993) Journal of Neurobiology , vol.24 , Issue.7 , pp. 959-970
    • Schreyer, D.J.1    Skene, J.H.P.2
  • 2
    • 0028032526 scopus 로고
    • GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the rat
    • DOI 10.1002/neu.480251209
    • Schaden H, Stuermer CA and Bahr M: GAP-43 immuno-reactivity and axon regeneration in retinal ganglion cells of the rat. J Neurobiol 25: 1570-1578, 1994. (Pubitemid 24357119)
    • (1994) Journal of Neurobiology , vol.25 , Issue.12 , pp. 1570-1578
    • Schaden, H.1    Stuermer, C.A.O.2    Bahr, M.3
  • 3
    • 20444364506 scopus 로고    scopus 로고
    • Overcoming inhibitors in myelin to promote axonal regeneration
    • DOI 10.1016/j.jns.2005.03.023, PII S0022510X05000808, Preserve the Neuron. Brain Atrophy, Axonal Loss, Remyelination and Stem Cells in MS. European Charcot Foundation Symposium
    • Domeniconi M and Filbin MT: Overcoming inhibitors in myelin to promote axonal regeneration. J Neurol Sci 233: 43-47, 2005. (Pubitemid 40804814)
    • (2005) Journal of the Neurological Sciences , vol.233 , Issue.1-2 , pp. 43-47
    • Domeniconi, M.1    Filbin, M.T.2
  • 4
    • 77952636619 scopus 로고    scopus 로고
    • MAG and OMgp synergize with Nogo - A to restrict axonal growth and neurological recovery after spinal cord trauma
    • Cafferty WB, Duffy P, Huebner E and Strittmatter SM: MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma. J Neurosci 30: 6825-6837, 2010.
    • (2010) J Neurosci , vol.30 , pp. 6825-6837
    • Cafferty, W.B.1    Duffy, P.2    Huebner, E.3    Strittmatter, S.M.4
  • 5
    • 0037031945 scopus 로고    scopus 로고
    • Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substrates
    • DOI 10.1074/jbc.M201195200
    • Winton MJ, Dubreuil CI, Lasko D, Leclerc N and McKerracher L: Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substrates. J Biol Chem 277: 32820-32829, 2002. (Pubitemid 34984792)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 32820-32829
    • Winton, M.J.1    Dubreuil, C.I.2    Lasko, D.3    Leclerc, N.4    McKerracher, L.5
  • 7
    • 13944274451 scopus 로고    scopus 로고
    • Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats
    • DOI 10.1523/JNEUROSCI.3931-04.2005
    • Bertrand J, Winton MJ, Rodriguez-Hernandez N, Campenot RB and McKerracher L: Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J Neurosci 25: 1113-1121, 2005. (Pubitemid 40268952)
    • (2005) Journal of Neuroscience , vol.25 , Issue.5 , pp. 1113-1121
    • Bertrand, J.1    Winton, M.J.2    Rodriguez-Hernandez, N.3    Campenot, R.B.4    McKerracher, L.5
  • 8
    • 37549015155 scopus 로고    scopus 로고
    • ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells
    • Lingor P, Tönges L, Pieper N, Bermel C, Barski E, Planchamp V and Bähr M: ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain 131: 250-263, 2008.
    • (2008) Brain , vol.131 , pp. 250-263
    • Lingor, P.1    Tönges, L.2    Pieper, N.3    Bermel, C.4    Barski, E.5    Planchamp, V.6    Bähr, M.7
  • 10
    • 0038024241 scopus 로고    scopus 로고
    • Rocks: Multifunctional kinases in cell behaviour
    • DOI 10.1038/nrm1128
    • Riento K and Ridley AJ: Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4: 446-456, 2003. (Pubitemid 36648590)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.6 , pp. 446-456
    • Riento, K.1    Ridley, A.J.2
  • 11
    • 41749091574 scopus 로고    scopus 로고
    • Applications for ROCK kinase inhibition
    • Olson MF: Applications for ROCK kinase inhibition. Curr Opin Cell Biol 20: 242-248, 2008.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 242-248
    • Olson, M.F.1
  • 12
    • 0346750740 scopus 로고    scopus 로고
    • Myosin function in nervous and sensory systems
    • DOI 10.1002/neu.10285
    • Brown ME and Bridgman PC: Myosin function in nervous and sensory systems. J Neurobiol 58: 118-130, 2004. (Pubitemid 37543343)
    • (2004) Journal of Neurobiology , vol.58 , Issue.1 , pp. 118-130
    • Brown, M.E.1    Bridgman, P.C.2
  • 14
    • 77951713077 scopus 로고    scopus 로고
    • Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism
    • Mehta NR, Nguyen T, Bullen JW Jr, Griffin JW and Schnaar RL: Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism. ACS Chem Neurosci 1: 215-222, 2010.
    • (2010) ACS Chem Neurosci , vol.1 , pp. 215-222
    • Mehta, N.R.1    Nguyen, T.2    Bullen Jr., J.W.3    Griffin, J.W.4    Schnaar, R.L.5
  • 15
    • 77956232928 scopus 로고    scopus 로고
    • Regeneration of optic nerve fibers of adult mammals
    • Watanabe M: Regeneration of optic nerve fibers of adult mammals. Dev Growth Differ 52: 567-576, 2010.
    • (2010) Dev Growth Differ , vol.52 , pp. 567-576
    • Watanabe, M.1
  • 16
    • 79960729300 scopus 로고    scopus 로고
    • Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells
    • Ramachandran C, Patil RV, Combrink K, Sharif NA and Srinivas SP: Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells. Mol Vis 17: 1877-1890, 2011.
    • (2011) Mol Vis , vol.17 , pp. 1877-1890
    • Ramachandran, C.1    Patil, R.V.2    Combrink, K.3    Sharif, N.A.4    Srinivas, S.P.5
  • 17
    • 34247210251 scopus 로고    scopus 로고
    • A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats
    • DOI 10.1016/j.expneurol.2007.02.002, PII S0014488607000611
    • Sagawa H, Terasaki H, Nakamura M, Ichikawa M, Yata T, Tokita Y and Watanabe M: A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp Neurol 205: 230-240, 2007. (Pubitemid 46617509)
    • (2007) Experimental Neurology , vol.205 , Issue.1 , pp. 230-240
    • Sagawa, H.1    Terasaki, H.2    Nakamura, M.3    Ichikawa, M.4    Yata, T.5    Tokita, Y.6    Watanabe, M.7
  • 18
    • 80053320552 scopus 로고    scopus 로고
    • Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats
    • Tokushige H, Waki M, Takayama Y and Tanihara H: Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res 36: 964-970, 2011.
    • (2011) Curr Eye Res , vol.36 , pp. 964-970
    • Tokushige, H.1    Waki, M.2    Takayama, Y.3    Tanihara, H.4
  • 19
    • 33747877312 scopus 로고    scopus 로고
    • A rat model of glaucoma induced by episcleral vein ligation
    • DOI 10.1016/j.exer.2006.03.014, PII S0014483506001989
    • Yu S, Tanabe T and Yoshimura N: A rat model of glaucoma induced by episcleral vein ligation. Exp Eye Res 83: 758-770, 2006. (Pubitemid 44292671)
    • (2006) Experimental Eye Research , vol.83 , Issue.4 , pp. 758-770
    • Yu, S.1    Tanabe, T.2    Yoshimura, N.3
  • 20
    • 0034659957 scopus 로고    scopus 로고
    • Lens injury stimulates axon regeneration in the mature rat optic nerve
    • Leon S, Yin Y, Nguyen J, Irwin N and Benowitz LI: Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 20: 4615-4626, 2000. (Pubitemid 30396627)
    • (2000) Journal of Neuroscience , vol.20 , Issue.12 , pp. 4615-4626
    • Leon, S.1    Yin, Y.2    Nguyen, J.3    Irwin, N.4    Benowitz, L.I.5
  • 21
    • 0033753722 scopus 로고    scopus 로고
    • Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture
    • Fischer D, Pavlidis M and Thanos S: Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture. Invest Ophthalmol Vis Sci 41: 3943-3954, 2000.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3943-3954
    • Fischer, D.1    Pavlidis, M.2    Thanos, S.3
  • 22
    • 0031915402 scopus 로고    scopus 로고
    • Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity
    • Berkowitz BA, Lukaszew RA, Mullins CM and Penn JS: Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci 39: 391-396, 1998. (Pubitemid 28093878)
    • (1998) Investigative Ophthalmology and Visual Science , vol.39 , Issue.2 , pp. 391-396
    • Berkowitz, B.A.1    Lukaszew, R.A.2    Mullins, C.M.3    Penn, J.S.4
  • 24
    • 0042171820 scopus 로고    scopus 로고
    • Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system
    • DOI 10.1083/jcb.200301080
    • Dubreuil CI, Winton MJ and McKerracher L: Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system. J Cell Biol 162: 233-243, 2004. (Pubitemid 36928837)
    • (2003) Journal of Cell Biology , vol.162 , Issue.2 , pp. 233-243
    • Dubreuil, C.I.1    Winton, M.J.2    McKerracher, L.3
  • 25
    • 33745113228 scopus 로고    scopus 로고
    • NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro
    • DOI 10.1093/brain/awl080
    • Ahmed Z, Suggate EL, Brown ER, Dent RG, Armstrong SJ, Barrett LB, Berry M and Logan A: Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro. Brain 129: 1517-1533, 2006. (Pubitemid 43999384)
    • (2006) Brain , vol.129 , Issue.6 , pp. 1517-1533
    • Ahmed, Z.1    Suggate, E.L.2    Brown, E.R.3    Dent, R.G.4    Armstrong, S.J.5    Barrett, L.B.6    Berry, M.7    Logan, A.8
  • 28
    • 34548638861 scopus 로고    scopus 로고
    • Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo
    • DOI 10.1111/j.1471-4159.2007.04756.x
    • Lingor P, Teusch N, Schwarz K, Mueller R, Mack H, Bähr M and Mueller BK: Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J Neurochem 103: 181-189, 2007. (Pubitemid 47404219)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.1 , pp. 181-189
    • Lingor, P.1    Teusch, N.2    Schwarz, K.3    Mueller, R.4    Mack, H.5    Bahr, M.6    Mueller, B.K.7
  • 29
    • 80054754483 scopus 로고    scopus 로고
    • Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries
    • Watabe H, Abe S and Yoshitomi T: Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries. Jpn J Ophthalmol 55: 411-417, 2011.
    • (2011) Jpn J Ophthalmol , vol.55 , pp. 411-417
    • Watabe, H.1    Abe, S.2    Yoshitomi, T.3
  • 30
    • 17744397579 scopus 로고    scopus 로고
    • Contribution of ROCK in contraction of trabecular meshwork: Proposed mechanism for regulating aqueous outflow in monkey and human eyes
    • DOI 10.1002/jps.20285
    • Nakajima E, Nakajima T, Minagawa Y, Shearer TR and Azuma M: Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes. J Pharm Sci 94: 701-708, 2005. (Pubitemid 40577304)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.4 , pp. 701-708
    • Nakajima, E.1    Nakajima, T.2    Minagawa, Y.3    Shearer, T.R.4    Azuma, M.5
  • 31
    • 34548073671 scopus 로고    scopus 로고
    • Effects of topical administration of Y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys
    • DOI 10.1167/iovs.05-1617
    • Tokushige H, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M and Tanihara H: Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Ophthalmol Vis Sci 48: 3216-3222, 2007. (Pubitemid 351261166)
    • (2007) Investigative Ophthalmology and Visual Science , vol.48 , Issue.7 , pp. 3216-3222
    • Tokushige, H.1    Inatani, M.2    Nemoto, S.3    Sakaki, H.4    Katayama, K.5    Uehata, M.6    Tanihara, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.