Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries

Japanese Journal of Ophthalmology

Volumn 55, Issue 4, 2011, Pages 411-417

  Watabe, Hiroshi ^a   Abe, Sanae ^a   Yoshitomi, Takeshi ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Keywords Ca2+; ROCK inhibitor; Vasodilator; Y 27632; Y 39983

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM; HISTAMINE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM; PROSTACYCLIN; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG; Y 39983;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CALCIUM CELL LEVEL; CILIARY ARTERY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLUOROPHOTOMETRY; IN VITRO STUDY; INHIBITION KINETICS; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE CONTRACTION;

AMIDES; ANIMALS; CALCIUM; CILIARY ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROPHOTOMETRY; INDOMETHACIN; MALE; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; PYRIDINES; RABBITS; RHO-ASSOCIATED KINASES; VASODILATION;

EID: 80054754483     PISSN: 00215155     EISSN: 16132246     Source Type: Journal    
DOI: 10.1007/s10384-011-0048-9     Document Type: Article

References (36)

1. Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359-93 (Pubitemid 34879080)
2. Sato EA, Ohtake Y, Shinoda K, Mashima Y, Kimura I. Decreased blood flow at neuroretinal rim of optic nerve head corresponds with visual field deficit in eyes with normal tension glaucoma. Graefes Arch Clin Exp Ophthalmol. 2006;244:795-801 (Pubitemid 44103324)
3. Altan-Yaycioglu R, Türker G, Akdöl S, Acunaş G, Izgi B. The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: A color Doppler imaging study. Eur J Ophthalmol. 2001;11:37-46 (Pubitemid 32233927)
4. Mizuno K, Koide T, Saito N, Fujii M, Nagahara M, Tomidokoro A, et al. Topical nipradilol: Effects on optic nerve head circulation in humans and periocular distribution in monkeys. Invest Ophthalmol Vis Sci. 2002;43:3243-50
5. Kurashima H, Watabe H, Sato N, Abe S, Ishida N, Yoshitomi T. Effects of prostaglandin F(2a) analogues on endothelin-1-induced impairment of rabbit ocular blood flow: Comparison among tafluprost, travoprost, and latanoprost. Exp Eye Res. 2010;91: 853-9
6. Hayashi-Morimoto R, Yoshitomi T, Ishikawa H, Hayashi E, Sato Y. Effects of beta antagonists on mechanical properties in rabbit ciliary artery. Graefes Arch Clin Exp Ophthalmol. 1999;237: 661-7 (Pubitemid 29358764)
7. Dong Y, Ishikawa H, Wu Y, Shimizu K, Goseki T, Yoshitomi T. Effect and mechanisms of betaxolol and timolol on vascular relaxation in isolated rabbit ciliary artery. Jpn J Ophthalmol. 2006;50:504-8 (Pubitemid 44974219)
8. Dong Y, Ishikawa H, Wu Y, Yoshitomi T. Vasodilatory mechanism of levobunolol on vascular smooth muscle cells. Exp Eye Res. 2007;84:1039-46 (Pubitemid 46770718)
9. Yoshitomi T, Yamaji K, Ishikawa H, Ohnishi Y. Vasodilatory effects of nipradilol, an alpha- and beta-adrenergic blocker with nitric oxide releasing action, in rabbit ciliary artery. Exp Eye Res. 2002;75:669-76 (Pubitemid 36034631)
10. Yoshitomi T, Yamaji K, Ishikawa H, Ohnishi Y. Vasodilatory mechanism of unoprostone isopropyl on isolated rabbit ciliary artery. Curr Eye Res. 2004;28:167-74 (Pubitemid 38365820)
11. Ishikawa H, Yoshitomi T, Mashimo K, Nakanishi M, Shimizu K. Pharmacological effects of latanoprost, prostaglandin E2 and F2a on isolated rabbit ciliary artery. Graefes Arch Clin Exp Ophthalmol. 2002;240:120-5 (Pubitemid 36075586)
12. Dong Y, Watabe H, Su G, Ishikawa H, Sato N, Yoshitomi T. Relaxing effect and mechanism of tafluprost on isolated rabbit ciliary arteries. Exp Eye Res. 2008;87:251-6
13. Honjo M, Tanihara H, Inatani M, Kido N, Yue BY, Narumiya S, et al. Effect of Rho-associated protein kinase inhibitor, Y-27632, on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci. 2001;42:137-44 (Pubitemid 32059420)
14. Waki M, Yoshida Y, Oka T, Azuma M. Reduction of intraocular pressure by topical administration of an inhibitor of the Rhoassociated protein kinase. Curr Eye Res. 2001;22:470-4 (Pubitemid 34253206)
15. Tokushige H, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M, et al. Effects of topical administration of Y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Ophthalmol Vis Sci. 2007;48: 3216-22 (Pubitemid 351261166)
16. Nishio M, Fukunaga T, Sugimoto M, Ikesugi K, Sumi K, Hidaka H, et al. The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes. Curr Eye Res. 2009;34:282-6
17. Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, et al. Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation. 2000;101:1319-23 (Pubitemid 30158621)
18. Sato M, Tani E, Fujikawa H, Kaibuchi K. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res. 2000;87:195-200 (Pubitemid 30626426)
19. Iizuka K, Shimizu Y, Tsukagoshi H, Yoshii A, Harada T, Dobashi K, et al. Evaluation of Y-27632, a rho-kinase inhibitor, as a bronchodilator in guinea pigs. Eur J Pharmacol. 2000;406:273-9
20. Takahashi R, Nishimura J, Hirano K, Seki N, Naito S, Kanaide H. Ca2+ sensitization in contraction of human bladder smooth muscle. J Urol. 2004;172:748-52 (Pubitemid 38900254)
21. Chitaley K, Wingard CJ, Clinton Webb R, Branam H, Stopper VS, Lewis RW, et al. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med. 2001;7:119-22 (Pubitemid 32095651)
22. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, et al. Calcium sensitization of smooth muscle mediated by Rhoassociated protein kinase in hypertension. Nature. 1997;389:990-4 (Pubitemid 27485693)
23. Nakajima E, Nakajima T, Minagawa Y, Shearer TR, Azuma M. Contribution of ROCK in contraction of trabecular meshwork: Proposed mechanism for regulating aqueous outflow in monkey and human eyes. J Pharm Sci. 2005;94:701-8 (Pubitemid 40577304)
24. Halpern W, Mulvany MJ, Warshaw DM. Mechanical properties of smooth muscle cells in the wall of arterial resistance vessels. J Physiol. 1978;275:85-101 (Pubitemid 8279718)
25. Mulvany MJ, Halpern W. Mechanical properties of vascular smooth muscle cells in situ. Nature. 1976;260:617-9
26. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977;41:19-26 (Pubitemid 8132079)
27. Keef KD, Bowen SM. Effect of Ach on electrical and mechanical activity in guinea pig coronary arteries. Am J Physiol. 1989;257:H1096-103
28. Ushio-Fukai M, Abe S, Kobayashi S, Nishimura J, Kanaide H. Effects of isoprenaline on cytosolic calcium concentrations and on tension in the porcine coronary artery. J Physiol. 1993;462:679-96 (Pubitemid 23094502)
29. Sugiyama T, Shibata M, Kajiura S, Okuno T, Tonari M, Oku H, et al. Effects of Fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits. Invest Ophthalmol Vis Sci. 2011;52:64-9
30. Ishii K, Tomidokoro A, Nagahara M, Tamaki Y, Kanno M, Fukaya Y, et al. Effects of topical latanoprost on optic nerve head circulation in rabbits, monkeys, and humans. Invest Ophthalmol Vis Sci. 2001;42:2957-63 (Pubitemid 33035296)
31. Gustafsson H. Vasomotion and underlying mechanisms in small arteries. An in vitro study of rat blood vessels. Acta Physiol Scand Suppl. 1993;614:1-644
32. Laporte R, Laher I. Sarcoplasmic reticulum-sarcolemma interactions and vascular smooth muscle tone. J Vasc Res. 1997;34:325-43 (Pubitemid 27414503)
33. Schubert R, Kalentchuk VU, Krien U. Rho kinase inhibition partly weakens myogenic reactivity in rat small arteries by changing calcium sensitivity. Am J Physiol Heart Circ Physiol. 2002;283:H2288-95 (Pubitemid 35345932)
34. Hashiba Y, Tosaka M, Saito N, Imai H, Shimizu T, Sasaki T. Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries. Neurol Res. 2007;29:485-9 (Pubitemid 47311522)
35. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem. 1996;271:20246-9 (Pubitemid 26281788)
36. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996;273:245-8. (Pubitemid 26285892)