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Volumn 8, Issue 1, 2013, Pages

TSC1 Controls Distribution of Actin Fibers through Its Effect on Function of Rho Family of Small GTPases and Regulates Cell Migration and Polarity

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; HAMARTIN; MAMMALIAN TARGET OF RAPAMYCIN; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE INHIBITOR; TUBERIN;

EID: 84872797974     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054503     Document Type: Article
Times cited : (16)

References (55)
  • 2
    • 0032438210 scopus 로고    scopus 로고
    • Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria
    • Roach ES, Gomez MR, Northrup H, (1998) Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol 13: 624-628.
    • (1998) J Child Neurol , vol.13 , pp. 624-628
    • Roach, E.S.1    Gomez, M.R.2    Northrup, H.3
  • 3
    • 77949882117 scopus 로고    scopus 로고
    • The tuberous sclerosis complex
    • Orlova KA, Crino PB, (2010) The tuberous sclerosis complex. Ann NY Acad Sci 1184: 87-105.
    • (2010) Ann NY Acad Sci , vol.1184 , pp. 87-105
    • Orlova, K.A.1    Crino, P.B.2
  • 4
    • 0036712905 scopus 로고    scopus 로고
    • Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    • Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, et al. (2002) Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4: 699-704.
    • (2002) Nat Cell Biol , vol.4 , pp. 699-704
    • Gao, X.1    Zhang, Y.2    Arrazola, P.3    Hino, O.4    Kobayashi, T.5
  • 5
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, et al. (2002) Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 99: 13571-13576.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5
  • 6
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL, (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 7
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, et al. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166: 213-223.
    • (2004) J Cell Biol , vol.166 , pp. 213-223
    • Harrington, L.S.1    Findlay, G.M.2    Gray, A.3    Tolkacheva, T.4    Wigfield, S.5
  • 8
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah OJ, Wang Z, Hunter T, (2004) Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 14: 1650-1656.
    • (2004) Curr Biol , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 9
    • 0030696314 scopus 로고    scopus 로고
    • Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis
    • Jones AC, Daniells CE, Snell RG, Tachataki M, Idziaszczyk SA, et al. (1997) Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis. Hum Mol Genet 6: 2155-2161.
    • (1997) Hum Mol Genet , vol.6 , pp. 2155-2161
    • Jones, A.C.1    Daniells, C.E.2    Snell, R.G.3    Tachataki, M.4    Idziaszczyk, S.A.5
  • 10
    • 0035167932 scopus 로고    scopus 로고
    • Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
    • Dabora SL, Jozwiak S, Franz DN, Roberts PS, Nieto A, et al. (2001) Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 68: 64-80.
    • (2001) Am J Hum Genet , vol.68 , pp. 64-80
    • Dabora, S.L.1    Jozwiak, S.2    Franz, D.N.3    Roberts, P.S.4    Nieto, A.5
  • 11
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL, (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17: 1829-1834.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 12
    • 0030064915 scopus 로고    scopus 로고
    • Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model
    • Tsuchiya H, Orimoto K, Kobayashi T, Hino O, (1996) Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model. Cancer Res 56: 429-433.
    • (1996) Cancer Res , vol.56 , pp. 429-433
    • Tsuchiya, H.1    Orimoto, K.2    Kobayashi, T.3    Hino, O.4
  • 13
    • 0032493629 scopus 로고    scopus 로고
    • Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members
    • Henry KW, Yuan X, Koszewski NJ, Onda H, Kwiatkowski DJ, et al. (1998) Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members. J Biol Chem 273: 20535-20539.
    • (1998) J Biol Chem , vol.273 , pp. 20535-20539
    • Henry, K.W.1    Yuan, X.2    Koszewski, N.J.3    Onda, H.4    Kwiatkowski, D.J.5
  • 14
    • 0032580368 scopus 로고    scopus 로고
    • A role of the tuberous sclerosis gene-2 product during neuronal differentiation
    • Soucek T, Hölzl G, Bernaschek G, Hengstschläger M, (1998) A role of the tuberous sclerosis gene-2 product during neuronal differentiation. Oncogene 16: 2197-2204.
    • (1998) Oncogene , vol.16 , pp. 2197-2204
    • Soucek, T.1    Hölzl, G.2    Bernaschek, G.3    Hengstschläger, M.4
  • 15
    • 0035019467 scopus 로고    scopus 로고
    • Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene
    • Kleymenova E, Ibraghimov-Beskrovnaya O, Kugoh H, Everitt J, Xu H, et al. (2001) Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol Cell 7: 823-832.
    • (2001) Mol Cell , vol.7 , pp. 823-832
    • Kleymenova, E.1    Ibraghimov-Beskrovnaya, O.2    Kugoh, H.3    Everitt, J.4    Xu, H.5
  • 16
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J, (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13: 1259-1268.
    • (2003) Curr Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 17
    • 12744255189 scopus 로고    scopus 로고
    • Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex
    • Nellist M, Sancak O, Goedbloed MA, Rohe C, van Netten D, et al. (2005) Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex. Eur J Hum Genet 13: 59-68.
    • (2005) Eur J Hum Genet , vol.13 , pp. 59-68
    • Nellist, M.1    Sancak, O.2    Goedbloed, M.A.3    Rohe, C.4    van Netten, D.5
  • 18
    • 4444276510 scopus 로고    scopus 로고
    • Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
    • Li Y, Inoki K, Guan KL, (2004) Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol 24: 7965-7975.
    • (2004) Mol Cell Biol , vol.24 , pp. 7965-7975
    • Li, Y.1    Inoki, K.2    Guan, K.L.3
  • 20
    • 0033775869 scopus 로고    scopus 로고
    • The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
    • Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, et al. (2000) The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol 2: 281-287.
    • (2000) Nat Cell Biol , vol.2 , pp. 281-287
    • Lamb, R.F.1    Roy, C.2    Diefenbach, T.J.3    Vinters, H.V.4    Johnson, M.W.5
  • 21
    • 0037113967 scopus 로고    scopus 로고
    • The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton
    • Haddad LA, Smith N, Bowser M, Niida Y, Murthy V, et al. (2002) The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton. J Biol Chem 277: 44180-44186.
    • (2002) J Biol Chem , vol.277 , pp. 44180-44186
    • Haddad, L.A.1    Smith, N.2    Bowser, M.3    Niida, Y.4    Murthy, V.5
  • 22
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A, (2002) Rho GTPases in cell biology. Nature 420: 629-35.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 23
    • 42049092972 scopus 로고    scopus 로고
    • Regulation of actin assembly associated with protrusion and adhesion in cell migration
    • Le Clainche C, Carlier MF, (2008) Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev 88: 489-513.
    • (2008) Physiol Rev , vol.88 , pp. 489-513
    • Le Clainche, C.1    Carlier, M.F.2
  • 24
    • 79959677602 scopus 로고    scopus 로고
    • Life at the leading edge
    • Ridley AJ, (2011) Life at the leading edge. Cell 145: 1012-1022.
    • (2011) Cell , vol.145 , pp. 1012-1022
    • Ridley, A.J.1
  • 25
    • 3042822399 scopus 로고    scopus 로고
    • Plakins: goliaths that link cell junctions and the cytoskeleton
    • Jefferson JJ, Leung CL, Liem RK, (2004) Plakins: goliaths that link cell junctions and the cytoskeleton. Nat Rev Mol Cell Biol 5: 542-553.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 542-553
    • Jefferson, J.J.1    Leung, C.L.2    Liem, R.K.3
  • 26
    • 33846847701 scopus 로고    scopus 로고
    • Rap1: a key regulator in cell-cell junction formation
    • Kooistra MR, Dubé N, Bos JL, (2007) Rap1: a key regulator in cell-cell junction formation. J Cell Sci 120: 17-22.
    • (2007) J Cell Sci , vol.120 , pp. 17-22
    • Kooistra, M.R.1    Dubé, N.2    Bos, J.L.3
  • 27
    • 50249107474 scopus 로고    scopus 로고
    • Paxillin comes of age
    • Deakin NO, Turner CE, (2008) Paxillin comes of age. J Cell Sci 121: 2435-2444.
    • (2008) J Cell Sci , vol.121 , pp. 2435-2444
    • Deakin, N.O.1    Turner, C.E.2
  • 28
    • 76349098227 scopus 로고    scopus 로고
    • Rho signaling and tight junction functions
    • Terry S, Nie M, Matter K, Balda MS, (2010) Rho signaling and tight junction functions. Physiology 25: 16-26.
    • (2010) Physiology , vol.25 , pp. 16-26
    • Terry, S.1    Nie, M.2    Matter, K.3    Balda, M.S.4
  • 29
    • 11244277987 scopus 로고    scopus 로고
    • TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
    • Goncharova E, Goncharov D, Noonan D, Krymskaya VP, (2004) TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J Cell Biol 167: 1171-82.
    • (2004) J Cell Biol , vol.167 , pp. 1171-1182
    • Goncharova, E.1    Goncharov, D.2    Noonan, D.3    Krymskaya, V.P.4
  • 30
    • 17844369428 scopus 로고    scopus 로고
    • The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
    • Benvenuto G, Li S, Brown SJ, Braverman R, Vass WC, et al. (2000) The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19: 6306-6316.
    • (2000) Oncogene , vol.19 , pp. 6306-6316
    • Benvenuto, G.1    Li, S.2    Brown, S.J.3    Braverman, R.4    Vass, W.C.5
  • 31
    • 33646854721 scopus 로고    scopus 로고
    • TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
    • Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, et al. (2006) TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem 281: 8313-8316.
    • (2006) J Biol Chem , vol.281 , pp. 8313-8316
    • Chong-Kopera, H.1    Inoki, K.2    Li, Y.3    Zhu, T.4    Garcia-Gonzalo, F.R.5
  • 32
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
    • Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, et al. (2002) A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11: 525-534.
    • (2002) Hum Mol Genet , vol.11 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3    Heiberger, K.M.4    Glogauer, M.5
  • 33
    • 0029814436 scopus 로고    scopus 로고
    • Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region
    • Jin F, Wienecke R, Xiao GH, Maize JC Jr, DeClue JE, et al. (1996) Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region. Proc Natl Acad Sci USA 93: 9154-9159.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9154-9159
    • Jin, F.1    Wienecke, R.2    Xiao, G.H.3    Maize Jr., J.C.4    DeClue, J.E.5
  • 34
    • 0030044323 scopus 로고    scopus 로고
    • Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells
    • Orimoto K, Tsuchiya H, Kobayashi T, Matsuda T, Hino O, (1996) Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells. Biochem Biophys Res Commun 219: 70-75.
    • (1996) Biochem Biophys Res Commun , vol.219 , pp. 70-75
    • Orimoto, K.1    Tsuchiya, H.2    Kobayashi, T.3    Matsuda, T.4    Hino, O.5
  • 35
    • 0033861013 scopus 로고    scopus 로고
    • The TSC1 gene product, hamartin, negatively regulates cell proliferation
    • Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, et al. (2000) The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum Mol Genet 9: 1721-1727.
    • (2000) Hum Mol Genet , vol.9 , pp. 1721-1727
    • Miloloza, A.1    Rosner, M.2    Nellist, M.3    Halley, D.4    Bernaschek, G.5
  • 36
    • 39849100440 scopus 로고    scopus 로고
    • Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
    • Hartsock A, Nelson WJ, (2008) Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 1778: 660-669.
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 660-669
    • Hartsock, A.1    Nelson, W.J.2
  • 37
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, et al. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22: 159-168.
    • (2006) Mol Cell , vol.22 , pp. 159-168
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3    Sheen, J.H.4    Hsu, P.P.5
  • 38
    • 34147146014 scopus 로고    scopus 로고
    • Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
    • Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, et al. (2007) Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 109: 3509-3512.
    • (2007) Blood , vol.109 , pp. 3509-3512
    • Zeng, Z.1    dos Sarbassov, D.2    Samudio, I.J.3    Yee, K.W.4    Munsell, M.F.5
  • 39
    • 0035902509 scopus 로고    scopus 로고
    • A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
    • Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, et al. (2001) A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci USA 98: 8762-8767.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8762-8767
    • Kobayashi, T.1    Minowa, O.2    Sugitani, Y.3    Takai, S.4    Mitani, H.5
  • 40
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    • Potter CJ, Huang H, Xu T, (2001) Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105: 357-368.
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 41
    • 0037028305 scopus 로고    scopus 로고
    • Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration
    • Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, et al. (2002) Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene 21: 8470-8476.
    • (2002) Oncogene , vol.21 , pp. 8470-8476
    • Astrinidis, A.1    Cash, T.P.2    Hunter, D.S.3    Walker, C.L.4    Chernoff, J.5
  • 42
    • 77955296990 scopus 로고    scopus 로고
    • Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1
    • Larson Y, Liu J, Stevens PD, Li X, Li J, et al. (2010) Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. J Biol Chem 285: 24987-24998.
    • (2010) J Biol Chem , vol.285 , pp. 24987-24998
    • Larson, Y.1    Liu, J.2    Stevens, P.D.3    Li, X.4    Li, J.5
  • 43
    • 80051495791 scopus 로고    scopus 로고
    • Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle
    • Zhou J, Shrikhande G, Xu J, McKay RM, Burns DK, et al. (2011) Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle. Genes Dev 25: 1595-1600.
    • (2011) Genes Dev , vol.25 , pp. 1595-1600
    • Zhou, J.1    Shrikhande, G.2    Xu, J.3    McKay, R.M.4    Burns, D.K.5
  • 44
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion, and adhesion during cell movement
    • Nobes CD, Hall A, (1999) Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 144: 1235-1244.
    • (1999) J Cell Biol , vol.144 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 45
    • 0028821093 scopus 로고
    • Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells
    • Yonemura S, Itoh M, Nagafuchi A, Tsukita S, (1995) Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells. J Cell Sci 108: 127-142.
    • (1995) J Cell Sci , vol.108 , pp. 127-142
    • Yonemura, S.1    Itoh, M.2    Nagafuchi, A.3    Tsukita, S.4
  • 46
    • 0036746704 scopus 로고    scopus 로고
    • Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium
    • Vaezi A, Bauer C, Vasioukhin V, Fuchs E, (2002) Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev Cell 3: 367-381.
    • (2002) Dev Cell , vol.3 , pp. 367-381
    • Vaezi, A.1    Bauer, C.2    Vasioukhin, V.3    Fuchs, E.4
  • 47
    • 29244449302 scopus 로고    scopus 로고
    • Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network
    • Hildebrand JD, (2005) Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J Cell Sci 118: 5191-5203.
    • (2005) J Cell Sci , vol.118 , pp. 5191-5203
    • Hildebrand, J.D.1
  • 48
    • 38349138921 scopus 로고    scopus 로고
    • EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
    • Abe K, Takeichi M, (2008) EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci USA 105: 3-19.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3-19
    • Abe, K.1    Takeichi, M.2
  • 50
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang J, Dibble CC, Matsuzaki M, Manning BD, (2008) The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 8: 4104-1415.
    • (2008) Mol Cell Biol , vol.8 , pp. 1415-4104
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 51
    • 68049126433 scopus 로고    scopus 로고
    • Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors
    • Huang J, Wu S, Wu CL, Manning BD, (2009) Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res 69: 6107-6114.
    • (2009) Cancer Res , vol.69 , pp. 6107-6114
    • Huang, J.1    Wu, S.2    Wu, C.L.3    Manning, B.D.4
  • 52
    • 81055130119 scopus 로고    scopus 로고
    • Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia
    • Chauhan BK, Lou M, Zheng Y, Lang RA, (2011) Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proc Natl Acad Sci USA 108: 18289-94.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 18289-18294
    • Chauhan, B.K.1    Lou, M.2    Zheng, Y.3    Lang, R.A.4
  • 53
    • 0033558236 scopus 로고    scopus 로고
    • Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas
    • Satake N, Kobayashi T, Kobayashi E, Izumi K, Hino O, (1999) Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas. Cancer Res 59: 849-855.
    • (1999) Cancer Res , vol.59 , pp. 849-855
    • Satake, N.1    Kobayashi, T.2    Kobayashi, E.3    Izumi, K.4    Hino, O.5
  • 54
    • 56149090835 scopus 로고    scopus 로고
    • The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition
    • Shiono M, Kobayashi T, Takahashi R, Sun G, Abe M, et al. (2008) The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition. Oncogene 27: 6690-6697.
    • (2008) Oncogene , vol.27 , pp. 6690-6697
    • Shiono, M.1    Kobayashi, T.2    Takahashi, R.3    Sun, G.4    Abe, M.5
  • 55
    • 0034667869 scopus 로고    scopus 로고
    • A new Western blotting method using polymer immunocomplexes: detection of Tsc1 and Tsc2 expression in various cultured cell lines
    • Fukuda T, Tani Y, Kobayashi T, Hirayama Y, Hino O, (2000) A new Western blotting method using polymer immunocomplexes: detection of Tsc1 and Tsc2 expression in various cultured cell lines. Anal Biochem 285: 274-276.
    • (2000) Anal Biochem , vol.285 , pp. 274-276
    • Fukuda, T.1    Tani, Y.2    Kobayashi, T.3    Hirayama, Y.4    Hino, O.5


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