Enhanced cytotoxicity and activation of ROS-dependent c-Jun NH 2-terminal kinase and caspase-3 by low doses of tetrandrine-loaded nanoparticles in Lovo cells - A possible Trojan strategy against cancer

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 75, Issue 3, 2010, Pages 334-340

  Li, Xiaolin ^a,d   Zhen, Donghui ^b   Lu, Xiaowei ^a   Xu, Hua'e ^a   Shao, Yun ^a   Xue, Qiping ^a   Hu, Yong ^c   Liu, Baorui ^d   Sun, Weihao ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

^d MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Anti tumor; C Jun NH 2 terminal kinase; Caspase 3; Nanoparticle; Reactive oxygen species (ROS); Tetrandrine

Indexed keywords

CASPASE 3; COPOLYMER; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TETRANDRINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG STABILITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; LOW DRUG DOSE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZYLISOQUINOLINES; BLOTTING, WESTERN; CASPASE 3; CELL LINE; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICROSCOPY, ATOMIC FORCE; NANOPARTICLES; REACTIVE OXYGEN SPECIES;

EID: 77954542990     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.04.016     Document Type: Article

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