Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 121-127

  Ito, Masanori ^a,c   Ikehama, Kiyoharu ^b   Yoshida, Koichi ^b   Haraguchi, Tamami ^c   Yoshida, Miyako ^c   Wada, Koichi ^a   Uchida, Takahiro ^c  

^a NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^b Alpha MOS Japan KK   (Japan)

^c MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Artificial sweetener; Bitterness prediction; Electronic tongue; H 1 antihistamines; Taste masking; Taste sensor

Indexed keywords

ACESULFAME POTASSIUM; ASPARTAME; AZELASTINE; CETIRIZINE; CHLORPHENIRAMINE; DIPHENHYDRAMINE; EPINASTINE; FEXOFENADINE; FLAVORING AGENT; HISTAMINE H1 RECEPTOR ANTAGONIST; KETOTIFEN; OLOPATADINE; QUININE; SWEETENING AGENT; UNCLASSIFIED DRUG; WATER; ACETOSULFAME; DIBENZAZEPINE DERIVATIVE; IMIDAZOLE DERIVATIVE; THIAZINE DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; BITTER TASTE; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; DRUG SOLUBILITY; ELECTRONIC TONGUE; ELECTRONICS; HUMAN; HUMAN EXPERIMENT; MASKING; MOLECULAR SENSOR; PREDICTION; PRIORITY JOURNAL; SCORING SYSTEM; SENSORY SYSTEM EXAMINATION; TONGUE; CHEMISTRY; ELECTROCHEMICAL ANALYSIS; TASTE; THEORETICAL MODEL;

DIBENZAZEPINES; ELECTROCHEMICAL TECHNIQUES; HISTAMINE H1 ANTAGONISTS; HUMANS; IMIDAZOLES; MODELS, THEORETICAL; SWEETENING AGENTS; TASTE; THIAZINES; TONGUE;

MLCS; MLOWN;

EID: 84872766401     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.11.047     Document Type: Article

References (19)

1. Alpha M.O.S. ASTREE Electrochemical Sensor Technology Technical Note T-SA 2004 S S04
2. V. Anand, M. Kataria, V. Kukkar, V. Saharan, and P.K. Choudhury The latest trends in the taste assessment of pharmaceuticals Drug Discov. Today 12 2007 257 265
3. Ayenew, Z., Puri, V., Kumar, L., Bansal, A.K., 2009. Trends in pharmaceutical taste masking technologies: a patent review. Recent Pat. Drug Deliv. Formul. 3, 26-39.
4. E.A. Baldwin, J. Bai, A. Plotto, and S. Dea Electronic noses and tongues: applications for the food and pharmaceutical industries Sensors 11 2011 4744 4766
5. R. Chopra, G. Alderborn, J.M. Newton, and F. Podczeck The influence of film coating on pellet properties Pharm. Dev. Tech. 7 2002 59 68
6. N. Funasaki, I. Uratsuji, T. Okuno, S. Hirota, and S. Neya Masking mechanisms of bitter taste of drugs studied with ion selective Chem. Pharm. Bull. 54 2006 1155 1161
7. Y. Hashimoto, C. Matsunaga, E. Tokuyama, E. Tsuji, T. Uchida, and H. Okada The quantitative prediction of bitterness-suppressing effect of sweeteners on the bitterness of famotidine by sweetness-responsive sensor Chem. Pharm. Bull. 55 2007 739 746
8. 1-receptor antagonists using a taste sensor Sens. Mater 23 2011 483 492
9. M. Kataoka, E. Tokuyama, Y. Miyanaga, and T. Uchida The taste sensory evaluation of medical plants and Chinese medicines Int. J. Pharm. 351 2008 36 44
10. Y. Katsuragi, Y. Mitsui, T. Umeda, K. Otsuji, S. Yamasawa, and K. Kurihara Basic studies for the practical use of bitterness inhibitors: selective inhibition of bitterness by phospholipids Pharm. Res. 14 1997 720 724
11. P.C. Kayumba, N. Huyghebaert, C. Cordella, J.D. Ntawukuliryayo, C. Vervaet, and J.P. Remon Quinine sulphate pellets for flexible pediatric drug dosing: formulation development and evaluation of taste-masking efficiency using the electronic tongue Eur. J. Pharm. Biopharm. 66 2007 460 465
12. Y. Kikkawa, K. Toko, T. Matsuno, and K. Yamafuji Discrimination of taste of amino acids with a multichannel taste sensor Jpn. J. Appl. Phys. 32 1993 5731 5736
13. J. Szejtli, and L. Szente Elimination of bitter, disgusting tastes of drugs and foods by cyclodextrins Eur. J. Pharm. Biopharm. 61 2005 115 125
14. S. Takagi, K. Toko, K. Wada, H. Yamada, and K. Toyoshima Detection of suppression of bitterness by sweet substance using a multichannel taste sensor J. Pharm. Sci. 87 1998 552 555
15. S. Takagi, K. Toko, K. Wada, and T. Ohki Quantification of suppression of bitterness using an electronic tongue J. Pharm. Sci. 90 2001 2042 2048
16. T. Uchida, Y. Kobayashi, Y. Miyanaga, R. Tokubo, H. Ikezaki, A. Taniguchi, M. Nishikata, and K. Matsuyama A new method for evaluating the bitterness of medicines by semi-continuous measurement of adsorption using a taste sensor Chem. Pharm. Bull. 49 2001 1336 1339
17. T. Uchida, A. Tanigake, Y. Miyanaga, K. Matsuyama, M. Kunitomo, Y. Kobayashi, H. Ikezaki, and A. Taniguchi Evaluation of the bitterness of antibiotics using a taste sensor J. Pharm. Pharmacol. 55 2003 1479 1485
18. G.-W. Von Rymon Lipinski The new intense sweetener acesulfame K Food Chem. 16 1985 259 269
19. K. Woertz, C. Tissen, P. Kleinebudde, and J. Breitkreutz Performance qualification of an electronic tongue based on ICH guideline Q2 J. Pharm. Biomed. Anal. 51 2010 497 506