Quinine sulphate pellets for flexible pediatric drug dosing: Formulation development and evaluation of taste-masking efficiency using the electronic tongue

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 66, Issue 3, 2007, Pages 460-465

  Kayumba, P C ^a,b   Huyghebaert, N ^b   Cordella, C ^c   Ntawukuliryayo, J D ^a   Vervaet, C ^b   Remon, J P ^b  

^a UNIVERSITY OF RWANDA   (Rwanda)

^b GHENT UNIVERSITY   (Belgium)

^c Alpha MOS   (France)

Author keywords

Electronic tongue; Eudragit E PO; Extrusion spheronisation; Pediatric formulation; Pellets; Quinine sulphate; Taste masking

Indexed keywords

EUDRAGIT; PLASTICIZER; POLYMER; QUININE SULFATE; SEBACIC ACID DIBUTYL ESTER; STEARIC ACID; WATER;

ARTICLE; BITTER TASTE; BODY WEIGHT; DRUG COATING; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STORAGE; ELECTRONIC SENSOR; EVALUATION; HUMIDITY; MASKING; PEDIATRICS; PELLET EXTRUSION; SPHERONIZATION; TABLET; TASTE;

BIOSENSING TECHNIQUES; CHEMISTRY, PHARMACEUTICAL; CHILD; HUMANS; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; QUININE; TASTE; TECHNOLOGY, PHARMACEUTICAL; TONGUE;

EID: 34248531273     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.11.018     Document Type: Article

References (18)

1. Nahata M.C. Pediatric drug formulation: challenges and potential solutions. Ann. Pharmacother. 33 (1999) 247-249
2. Choonara I., and Conroy S. Unlicensed and off-label drug use in children: implication for safety. Drug Saf. 25 (2002) 1-5
3. Kristensen H.G., Jorgensen G.H., and Sonnegaard J.M. Mass uniformity of tablets broken by hand. Pharmeuropa 7 (1995) 298-302
4. Gupta P., and Gupta K. Broken tablets: does the sum of the parts equal the whole?. Am. J. Hosp. Pharm. 45 (1988) 1498
5. Myriam S., Philippe A., Fontan J.E., and Brion F. Splitting tablets in half. Am. J. Hosp. Pharm. 15 (1994) 548-550
6. Mc Devitt J.T., Gurst A.H., and Chen Y. Accuracy of tablet splitting. Pharmacotherapy 18 (1998) 193-197
7. Breitkreutz J., Wessel T., and Boos J. Dosage forms for peroral drug administration to children. Pediatr. Perinat. Drug Ther. 3 (1999) 25-33
8. Suzuki H., Hiraku O., Yuri T., Masaroni I., and Yoshiharu M. Development of oral acetaminophen chewable tablets with inhibited bitter taste. Int. J. Pharm. 251 (2003) 123-132
9. Katsuragi Y., Mitsui Y., Umeda T., Otsuji K., Yamasawa S., and Kurihara K. Basic studies for the practical use of bitterness inhibitors: selective inhibition of bitterness by phospholipids. Pharm. Res. 14 (1997) 720-724
10. Sohi H., Sultana Y., and Khar R.K. Taste masking technologies in oral pharmaceuticals: recent developments and approaches. Drug Dev. Ind. Pharm. 30 5 (2004) 429-448
11. Podczeck F., and Newton J.M. A shape factor to characterize the quality of spheroids. J. Pharm. Pharmacol. 46 (1994) 82-85
12. Vlasov Y., Legin A., and Rudnitskaya A. Electronic tongues and their analytical application. Anal. Bioanal. Chem. 373 (2002) 136-146
13. Wesseling M., Kuppler F., and Bodmeier R. Tackiness of acrylic and cellulosic polymer films used in the coating of solid dosage forms. Eur. J. Pharm. Biopharm. 47 (1999) 73-78
14. ® E PO, 33rd International Eudragit workshop, Darmstadt, Germany, 2001.
15. Petereit H.U., and Weisbrod W. Formulation and process considerations affecting the stability of solid dosage formulated with methacrylate copolymers. Eur. J. Pharm. Biopharm. 47 (1999) 15-25
16. Thoma K., and Bechtold K. Influence of aqueous coatings on the stability of enteric coated pellets and tablets. Eur. J. Pharm. Biopharm. 47 (1999) 39-50
17. Pedersen A.M., Bardow A., Jansen B.S., and Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 8 (2002) 117-129
18. Klancke J. Dissolution testing of orally disintegrating tablets. Dissol. Technol. 10 (2003) 6-8