GABAa receptor α1 and β2 subunit null mutant mice: Behavioral responses to ethanol

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 3, 2003, Pages 854-863

  Blednov, Y A ^a   Walker, D ^a   Alva, H ^a   Creech, K ^a   Findlay, G ^a   Harris, R A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; QUININE; RECEPTOR SUBUNIT; SACCHARIN; CENTRAL DEPRESSANT AGENT;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; FEMALE; GENE DELETION; MOTOR PERFORMANCE; MOUSE; MUTANT; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; SEIZURE; TASTE AVERSION; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CONDITIONED REFLEX; DRINKING BEHAVIOR; DRUG EFFECT; GENETICS; METABOLISM; MOTOR ACTIVITY; MOUSE MUTANT; PATHOPHYSIOLOGY;

ALCOHOL DRINKING; ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDITIONING, CLASSICAL; ETHANOL; FEMALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; RECEPTORS, GABA-A;

EID: 0037799867     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.049478     Document Type: Article

References (40)

1. Balakleevsky A, Colombo G, Fadda F, and Gessa GL (1990) Ro 19-4603, a benzodiazepine receptor inverse agonist, attenuates voluntary ethanol consumption in rats selectively bred for high ethanol preference. Alcohol Alcohol 25:449-452.
2. Berridge KC and Pecina S (1995) Benzodiazepines, appetite and taste palatability. Neurosci Biobehav Rev 19:121-131.
3. Berridge KC and Treit D (1986) Chlordiazepoxide directly enhances positive ingestive reactions in rats. Pharmacol Biochem Behav 24:217-221.
4. Blednov YA, Jung S, Alva H, Wallace D, Rosahl T, Whiting PJ, and Harris RA (2003) Deletion of the alpha1 or beta2 subunit of GABAA receptor reduces actions of alcohol and other drugs. J Pharmacol Exp Ther 304:30-36.
5. Boyle AE, Segal R, Smith BR, and Amit Z (1993) Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats. Pharmacol Biochem Behav 46:179-182.
6. Broadbent J and Harless WE (1999) Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2J mice. Psychopharmacology 141:197-205.
7. Buck KJ and Finn DA (2001) Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction 96:139-149.
8. Buck KJ and Hood HM (1998) Genetic association of a GABAA receptor γ2 subunit variant with severity of acute physiological dependence on alcohol. Mamm Genome 9:975-978.
9. Chester JA and Cunningham CL (2002) GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 26:131-143.
10. Crabbe JC, Merrill C, and Belknap JK (1991) Acute dependence on depressant drugs is determined by common genes in mice. J Pharmacol Exp Ther 257:663-667.
11. Cunningham CL (1993) Pavlovian drug conditioning, in Methods in Behavioral Pharmacology (F van Haaren ed) pp 349-381, Elsevier, New York.
12. 1 subtype in the ventral pallidum regulates alcohol-seeking behaviors. J Neurosci 22:3765-3775.
13. Hinko CN and Rozanov C (1990) The role of bicuculline, aminooxyacetic acid and gabaculine in the modulation of ethanol-induced motor impairment. Eur J Pharmacol 182:261-271.
14. Hodge CW and Cox AA (1998) The discriminative stimulus effects of ethanol are mediated by NMDA and GABAA receptors in specific limbic brain regions. Psychopharmacology 139:95-107.
15. Homanics GE, Ferguson C, Quinlan JJ, Daggett J, Snyder K, Lagenaur C, Mi ZP, Wang XH, Grayson DR, and Firestone LL (1997) Gene knockout of the α6 subunit of the γ-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital and general anesthetics. Mol Pharmacol 51:588-596.
16. Homanics GE, Harrison NL, Quinlan JJ, Krasowski MD, Rick CEM, de Blas AL, Mehta AK, Kist F, Mihalek RM, Aul JJ, et al. (1999) Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma 2 subunit of the gamma-aminobutyrate type A receptor. Neuropharmacology 38:253-255.
17. A receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 283:151-159.
18. Gunther U, Benson J, Benke D, Fritschy J, Reyes G, Knoflach F, Crestani F, Aguzzi A, Argoni M, Lang Y, et al. (1995) Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci USA 92:7749-7753.
19. Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, et al. (1997) Ligand-gated ion channel subunit partnerships: GABAA receptor α6 subunit gene inactivation inhibits δ subunit expression. J Neurosci 17:1350-1362.
20. June HL, Zuccarelli D, Torres L, Craig KS, DeLong J, Allen A, Braun MR, Cason CR, and Murphy JM (1998) High-affinity benzodiazepine antagonists reduce responding maintained by ethanol presentation in ethanol-preferring rats. J Pharmacol Exp Ther 284:1006-1014.
21. Koechling UM, Smith BR, and Amit Z (1991) Effects of GABA antagonists and habituation to novelty on ethanol-induced locomotor activity in mice. Alcohol Alcohol 26:315-322.
22. Korpi ER, Koikkalainen P, Vekovischeva OY, Mäkelä R, Kleinz R, Uusi-Oukari M, and Wisden W (1999) Cerebellar granule-cell-specific GABAA receptors attenuate benzodiazepine-induced ataxia: evidence from α6-subunit-deficient mice. Eur J Neurosci 11:233-240.
23. Kralic JE, Korpi ER, O'Buckley TK, Homanics GE, and Morrow AL (2002a) Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice. J Pharmacol Exp Ther 302:1037-1045.
24. Kralic JE, O'Buckley TK, Khisti RT, Hodge CW, Homanics GE, and Morrow AL (2002b) GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology 43:685-694.
25. Loh EW and Ball D (2000) Role of the GABA(A) beta2, GABA(A) alpha6, GABA(A) alpha1 and GABA(A) gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence. Neurochem Int 37:413-423.
26. Lundquist F (1959) The determination of ethyl alcohol in blood and tissue. Methods Biochem Anal 7:217-251.
27. A receptor subunit antisense oligodeoxynucleotides. Alcohol Alcohol 36:309-313.
28. McKernan RM and Whiting PJ (1996) Which GABAA receptor subtypes really occur in the brain. Trends Neurosci 19:139-143.
29. A receptors. Brain Res Rev 29:196-217.
30. Mihalek RM, Bowers BJ, Wehner JM, Kralic JE, VanDoren MJ, Morrow AL, and Homanics GE (2001) GABAA -Receptor delta Subunit Knockout Mice Have Multiple Defects in Behavioral Responses to Ethanol. Alcohol Clin Exp Res 25:1708-1718.
31. Quinlan JJ, Firestone LL, and Homanics GE (2000) Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines. Pharmacol Biochem Behav 66:371-374.
32. Schwarzer C, Berresheim U, Pirker S, Wieselthaler A, Fuchs K, Sieghart W, and Sperk G (2001) Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. J Comp Neurol 433:526-549.
33. Smith BR, Robidoux J, and Amit Z (1992) GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats. Alcohol Alcohol 27:227-231.
34. Snell LD, Szabo G, Tabakoff B, and Hoffman PA (1996) Gangliosides reduce the development of ethanol dependence without affecting ethanol tolerance. J Pharmacol Exp Ther 279:128-136.
35. Stevenson A, Wingrove PB, Whiting PJ, and Wafford KA (1995) beta-Carboline gamma-aminobutyric acid A receptor inverse agonists modulate gammaaminobutyric acid via the loreclezole binding site as well as the benzodiazepine site. Mol Pharmacol 48:965-969.
36. Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O'Meara G, Howell O, Newman R, et al. (2001) Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci 21:3409-3418.
37. A agonist, muscimol, on ethanol intake and measures of intoxication in Wistar rats. Alcohol Alcohol 29:551-558.
38. Wegelius K, Honkanen A, and Korpi ER (1994) Benzodiazepine receptor ligands modulate ethanol drinking in alcohol-preferring rats. Eur J Pharmacol 263: 141-147.
39. Wick MJ, Radcliffe RA, Bowers BJ, Mascia MP, Luscher B, Harris RA, and Wehner JM (2000) Behavioural changes produced by transgenic overexpression of gamma2L and gamma2S subunits of the GABAA receptor. Eur J Neurosci 12: 2634-2638.
40. Wingrove PB, Thompson SA, Wafford KA, and Whiting PJ (1997) Key amino acids in the α subunit of the γ-aminobutyric acid A receptor that determine ligand binding and modulation at the benzodiazepine site. Mol Pharmacol 52:874-881.