Presenilin 1 is frequently over-expressed and positively associates with epidermal growth factor receptor expression in head and neck squamous cell carcinoma

Head and Neck Oncology

Volumn 4, Issue 2, 2012, Pages

  Song, X ^a,b   Xia, R ^a,b   Cui, Z ^a,b   Chen, W ^a,b   Mao, L ^a,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Key Laboratory of Stomatology   (China)

^c UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PRESENILIN 1; SMALL INTERFERING RNA;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84872713979     PISSN: None     EISSN: 17583284     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Darnell RB, Posner JB. Paraneoplastic syndromes affecting the nervous system. Semin Oncol. 2006 Jun;33(3): 270-98. (Pubitemid 43849931)
2. Kosaka Y, Fujii M, Ishizuka S, Azumi M, Yamamoto T, Sasaki H. Dementia of patients with cancer. Geriatr Gerontol Int. 2010 Jul;10(3):269-71.
3. Bateman A, Bennett HP. The granulin gene family: from cancer to dementia. Bioessays. 2009 Nov;31(11):1245-54.
4. Morris LG, Veeriah S, Chan TA. Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene. 2010 Jun;29(24):3453-64.
5. Cao L, Liu X, Lin EJ, Wang C, Choi EY, Riban V, et al. Environmental and genetic activation of a brain-adipocyte BDNF/ leptin axis causes cancer remission and inhibition. Cell. 2010 Jul;142(1):52-64.
6. Roe CM, Fitzpatrick AL, Xiong C, Sieh W, Kuller L, Miller JP, et al. Cancer linked to Alzheimer disease but not vascular dementia. Neurology. 2010 Jan;74(2):106-12.
7. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995 Jun;375(6534): 754-60.
8. Telerman A, Amson R. The molecular programme of tumour reversion: the steps beyond malignant transformation. Nat Rev Cancer. 2009 Mar;9(3):206-16.
9. Roperch JP, Alvaro V, Prieur S, Tuynder M, Nemani M, Lethrosne F, et al. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nat Med. 1998 Jul;4(7):835-8. (Pubitemid 28331027)
10. Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, et al. Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene. 2010 May;29(20): 2950-61.
11. Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H. Presenilin/gamma- secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci USA. 2007 Jun;104(25):10613-8. (Pubitemid 47185713)
12. Repetto E, Yoon IS, Zheng H, Kang DE. Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J Biol Chem. 2007 Oct;282(43): 31504-16. (Pubitemid 350044898)
13. Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu DD, et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol. 2007 Jun;25(16):2164-70. (Pubitemid 46954638)
14. Mao L, Hong WK, Papadimitrakopoulou VA. Focus on head and neck cancer. Cancer Cell. 2004 Apr;5(4):311-6. (Pubitemid 38482067)
15. Cao W, Zhang ZY, Xu Q, Sun Q, Yan M, Zhang J, et al. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma. Mol Cancer. 2010 Nov;9:296.
16. Cao W, Feng Z, Cui Z, Zhang C, Sun Z, Mao L, et al. Up-regulation of enhancer of zeste homolog 2 is associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma. Cancer. 2012 Jun;118(11):2858-71.
17. Cao W, Younis RH, Li J, Chen H, Xia R, Mao L, et al. EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia. Cancer Prev Res (Phila). 2011 Nov;4(11):1816-24.
18. Janicki SM, Monteiro MJ. Presenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer's disease PS2(N141I) mutant. Am J Pathol. 1999 Jul;155(1): 135-44.
19. Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, et al. Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors. J Alzheimers Dis. 2009;16(3): 565-75.
20. Weisz L, Oren M, Rotter V. Transcription regulation by mutant p53. Oncogene. 2007 Apr;26(15):2202-11. (Pubitemid 46536644)
21. Song JI, Grandis JR. STAT signaling in head and neck cancer. Oncogene. 2000 May;19(21):2489-95. (Pubitemid 30339204)
22. Steiner H. The catalytic core of gammasecretase: presenilin revisited. Curr Alzheimer Res. 2008 Apr;5(2):147-57. (Pubitemid 351536339)
23. Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell. 2002 Jul;3(1):85-97. (Pubitemid 34778398)
24. Cooper E, Deng WM, Chung HM. Aph-1 is required to regulate Presenilinmediated gamma-secretase activity and cell survival in Drosophila wing development. Genesis. 2009 Mar;47(3): 169-74.
25. De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron. 2003 Apr;38(1):9-12. (Pubitemid 36423348)
26. Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, et al. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem. 2003 Mar; 278(10):7850-4. (Pubitemid 36800519)
27. Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, et al. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem. 2002 Oct;277(42): 39062-5. (Pubitemid 35190871)
28. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug;333(6046):1157-60.
29. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011 Aug;333(6046):1154-7.
30. Taoudi Benchekroun M, Saintigny P, Thomas SM, El-Naggar AK, Papadimitrakopoulou V, Ren H, et al. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev Res (Phila). 2010 Jul;3(7):800-9.
31. Hass MR, Sato C, Kopan R, Zhao G. Presenilin: RIP and beyond. Semin Cell Dev Biol. 2009 Apr;20(2):201-10.
32. Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, et al. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem. 2007 Nov;282(44):32264-73. (Pubitemid 350106457)