Aph-1 is required to regulate presenilin-mediated γ-secretase activity and cell survival in Drosophila wing development

Genesis

Volumn 47, Issue 3, 2009, Pages 169-174

  Cooper, Emilie ^a,b   Deng, Wu Min ^c   Chung, Hui Min ^a  

^a UNIVERSITY OF WEST FLORIDA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c FLORIDA STATE UNIVERSITY   (United States)

Author keywords

secretase; Aph 1; Cell survival; Notch; Presenilin

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; PRESENILIN; APH 1 PROTEIN, DROSOPHILA; APH-1 PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DEVELOPMENTAL BIOLOGY; DOWN REGULATION; DROSOPHILA; ENZYME ACTIVITY; FORELIMB; LIMB DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; CELL DIFFERENTIATION; DIMERIZATION; DROSOPHILA MELANOGASTER; GENETICS; LETTER; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; PROTEIN QUATERNARY STRUCTURE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; DIMERIZATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; MEMBRANE PROTEINS; PRESENILINS; PROTEIN STRUCTURE, QUATERNARY; WING;

EID: 67049161214     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20478     Document Type: Article

References (16)

1. Barakat A, Mercer B, Cooper E, Chung H-M. 2009. Examing requirement for formation of functional presenilin proteins and their processing events in vivo. Genes J Genet Dev doi: 10.1002/DVG20475.
2. Blair SS. 1996. Notch and wingless signals collide. Science 271:1822-1823.
3. Chen Q, Schubert D. 2002. Presenilin-interacting proteins. Expert Rev Mol Med 4:1-18.
4. Chung HM, Struhl G. 2001. Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nat Cell Biol 3:1129-1132.
5. Dries DR, Yu G. 2008. Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease. Curr Alzheimer Res 5:132-146.
6. Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. 2002. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3:85-97.
7. Goutte C, Tsunozaki M, Hale VA, Priess JR. 2002. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 99:775-779.
8. Hu Y, Fortini ME. 2003. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol 161:685-690.
9. Iwatsubo T. 2004. The gamma-secretase complex: Machinery for intramembrane proteolysis. Curr Opin Neurobiol 14:379-383.
10. Micchelli CA, Rulifson EJ, Blair SS. 1997. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124:1485-1495.
11. Parks AL, Curtis D. 2007. Presenilin diversifies its portfolio. Trends Genet 23:140-150.
12. Rulifson EJ, Micchelli CA, Axelrod JD, Perrimon N, Blair SS. 1996. Wingless refines its own expression domain on the Drosophila wing margin. Nature 384:72-74.
13. Schweisguth F. 2004. Notch signaling activity. Curr Biol 14:R129-R138.
14. Struhl G, Greenwald I. 1999. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398:522-525.
15. Struhl G, Greenwald I. 2001. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci USA 98:229-234.
16. Xu T, Rubin GM. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117:1223-1237.