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Volumn 55, Issue 1, 2013, Pages 12-18

Using metabolomics to assess myocardial metabolism and energetics in heart failure

Author keywords

Congestive heart failure; Energetics; Metabolomics

Indexed keywords

AMINO ACID; KETONE BODY; PENTOSE PHOSPHATE;

EID: 84872677864     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.08.025     Document Type: Review
Times cited : (44)

References (87)
  • 1
    • 79952444246 scopus 로고    scopus 로고
    • Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association
    • M 1
    • Heidenreich P.A., Trogdon J.G., Khavjou O.A., Butler J., Dracup K., Ezekowitz M.D., et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation Mar 1 2011, 123(8):933-944.
    • (2011) Circulation , vol.123 , Issue.8 , pp. 933-944
    • Heidenreich, P.A.1    Trogdon, J.G.2    Khavjou, O.A.3    Butler, J.4    Dracup, K.5    Ezekowitz, M.D.6
  • 2
    • 3142745348 scopus 로고    scopus 로고
    • Trends in heart failure incidence and survival in a community-based population
    • J 21
    • Roger V.L., Weston S.A., Redfield M.M., Hellermann-Homan J.P., Killian J., Yawn B.P., et al. Trends in heart failure incidence and survival in a community-based population. JAMA Jul 21 2004, 292(3):344-350.
    • (2004) JAMA , vol.292 , Issue.3 , pp. 344-350
    • Roger, V.L.1    Weston, S.A.2    Redfield, M.M.3    Hellermann-Homan, J.P.4    Killian, J.5    Yawn, B.P.6
  • 4
    • 0037206364 scopus 로고    scopus 로고
    • Long-term trends in the incidence of and survival with heart failure
    • O 31
    • Levy D., Kenchaiah S., Larson M.G., Benjamin E.J., Kupka M.J., Ho K.K., et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med Oct 31 2002, 347(18):1397-1402.
    • (2002) N Engl J Med , vol.347 , Issue.18 , pp. 1397-1402
    • Levy, D.1    Kenchaiah, S.2    Larson, M.G.3    Benjamin, E.J.4    Kupka, M.J.5    Ho, K.K.6
  • 5
    • 0037010011 scopus 로고    scopus 로고
    • Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy
    • O 2
    • Beer M., Seyfarth T., Sandstede J., Landschutz W., Lipke C., Kostler H., et al. Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol Oct 2 2002, 40(7):1267-1274.
    • (2002) J Am Coll Cardiol , vol.40 , Issue.7 , pp. 1267-1274
    • Beer, M.1    Seyfarth, T.2    Sandstede, J.3    Landschutz, W.4    Lipke, C.5    Kostler, H.6
  • 6
    • 0031884306 scopus 로고    scopus 로고
    • Human myocardial ATP content and in vivo contractile function
    • M
    • Starling R.C., Hammer D.F., Altschuld R.A. Human myocardial ATP content and in vivo contractile function. Mol Cell Biochem Mar 1998, 180(1-2):171-177.
    • (1998) Mol Cell Biochem , vol.180 , Issue.1-2 , pp. 171-177
    • Starling, R.C.1    Hammer, D.F.2    Altschuld, R.A.3
  • 7
    • 0028050777 scopus 로고
    • Bioenergetics. Dissecting the role of creatine kinase
    • v
    • Wallimann T. Bioenergetics. Dissecting the role of creatine kinase. Curr Biol Jan 1 1994, 4(1):42-46.
    • (1994) Curr Biol , vol.4 , Issue.1 , pp. 42-46
    • Wallimann, T.1
  • 8
    • 0021436518 scopus 로고
    • A simple analysis of the "phosphocreatine shuttle"
    • M
    • Meyer R.A., Sweeney H.L., Kushmerick M.J. A simple analysis of the "phosphocreatine shuttle". Am J Physiol May 1984, 246(5 Pt 1):C365-C377.
    • (1984) Am J Physiol , vol.246 , Issue.5 PART 1
    • Meyer, R.A.1    Sweeney, H.L.2    Kushmerick, M.J.3
  • 9
    • 0025936039 scopus 로고
    • Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy
    • S
    • Bristow M.R., Anderson F.L., Port J.D., Skerl L., Hershberger R.E., Larrabee P., et al. Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy. Circulation Sep 1991, 84(3):1024-1039.
    • (1991) Circulation , vol.84 , Issue.3 , pp. 1024-1039
    • Bristow, M.R.1    Anderson, F.L.2    Port, J.D.3    Skerl, L.4    Hershberger, R.E.5    Larrabee, P.6
  • 11
    • 85047675897 scopus 로고
    • Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy
    • J
    • Sylven C., Lin L., Jansson E., Sotonyi P., Fu L.X., Waagstein F., et al. Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy. Cardiovasc Res Jul 1993, 27(7):1295-1299.
    • (1993) Cardiovasc Res , vol.27 , Issue.7 , pp. 1295-1299
    • Sylven, C.1    Lin, L.2    Jansson, E.3    Sotonyi, P.4    Fu, L.X.5    Waagstein, F.6
  • 12
    • 4444286823 scopus 로고    scopus 로고
    • Transgenesis and cardiac energetics: new insights into cardiac metabolism
    • S
    • Ingwall J.S. Transgenesis and cardiac energetics: new insights into cardiac metabolism. J Mol Cell Cardiol Sep 2004, 37(3):613-623.
    • (2004) J Mol Cell Cardiol , vol.37 , Issue.3 , pp. 613-623
    • Ingwall, J.S.1
  • 13
    • 0035920253 scopus 로고    scopus 로고
    • Energetic crosstalk between organelles: architectural integration of energy production and utilization
    • J 20
    • Kaasik A., Veksler V., Boehm E., Novotova M., Minajeva A., Ventura-Clapier R. Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res Jul 20 2001, 89(2):153-159.
    • (2001) Circ Res , vol.89 , Issue.2 , pp. 153-159
    • Kaasik, A.1    Veksler, V.2    Boehm, E.3    Novotova, M.4    Minajeva, A.5    Ventura-Clapier, R.6
  • 14
    • 0033840893 scopus 로고    scopus 로고
    • Glycolysis supports calcium uptake by the sarcoplasmic reticulum in skinned ventricular fibres of mice deficient in mitochondrial and cytosolic creatine kinase
    • J
    • Boehm E., Ventura-Clapier R., Mateo P., Lechene P., Veksler V. Glycolysis supports calcium uptake by the sarcoplasmic reticulum in skinned ventricular fibres of mice deficient in mitochondrial and cytosolic creatine kinase. J Mol Cell Cardiol Jun 2000, 32(6):891-902.
    • (2000) J Mol Cell Cardiol , vol.32 , Issue.6 , pp. 891-902
    • Boehm, E.1    Ventura-Clapier, R.2    Mateo, P.3    Lechene, P.4    Veksler, V.5
  • 16
    • 0037306641 scopus 로고    scopus 로고
    • Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine
    • F
    • Boehm E., Chan S., Monfared M., Wallimann T., Clarke K., Neubauer S. Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. Am J Physiol Endocrinol Metab Feb 2003, 284(2):E399-E406.
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , Issue.2
    • Boehm, E.1    Chan, S.2    Monfared, M.3    Wallimann, T.4    Clarke, K.5    Neubauer, S.6
  • 17
    • 77953817830 scopus 로고    scopus 로고
    • Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells
    • J
    • Li H., Thali R.F., Smolak C., Gong F., Alzamora R., Wallimann T., et al. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol Jul 2010, 299(1):F167-F177.
    • (2010) Am J Physiol Renal Physiol , vol.299 , Issue.1
    • Li, H.1    Thali, R.F.2    Smolak, C.3    Gong, F.4    Alzamora, R.5    Wallimann, T.6
  • 18
    • 30944442640 scopus 로고    scopus 로고
    • Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice
    • N 15
    • Wallis J., Lygate C.A., Fischer A., ten Hove M., Schneider J.E., Sebag-Montefiore L., et al. Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice. Circulation Nov 15 2005, 112(20):3131-3139.
    • (2005) Circulation , vol.112 , Issue.20 , pp. 3131-3139
    • Wallis, J.1    Lygate, C.A.2    Fischer, A.3    ten Hove, M.4    Schneider, J.E.5    Sebag-Montefiore, L.6
  • 19
    • 0032482127 scopus 로고    scopus 로고
    • Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase
    • M 4
    • Saupe K.W., Spindler M., Tian R., Ingwall J.S. Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase. Circ Res May 4 1998, 82(8):898-907.
    • (1998) Circ Res , vol.82 , Issue.8 , pp. 898-907
    • Saupe, K.W.1    Spindler, M.2    Tian, R.3    Ingwall, J.S.4
  • 20
    • 84855420869 scopus 로고    scopus 로고
    • Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved
    • J 3
    • Gupta A., Akki A., Wang Y., Leppo M.K., Chacko V.P., Foster D.B., et al. Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. J Clin Invest Jan 3 2012, 122(1):291-302.
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 291-302
    • Gupta, A.1    Akki, A.2    Wang, Y.3    Leppo, M.K.4    Chacko, V.P.5    Foster, D.B.6
  • 22
    • 33646832738 scopus 로고    scopus 로고
    • Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction
    • M 31
    • Augustus A.S., Buchanan J., Park T.S., Hirata K., Noh H.L., Sun J., et al. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem Mar 31 2006, 281(13):8716-8723.
    • (2006) J Biol Chem , vol.281 , Issue.13 , pp. 8716-8723
    • Augustus, A.S.1    Buchanan, J.2    Park, T.S.3    Hirata, K.4    Noh, H.L.5    Sun, J.6
  • 24
    • 79551498811 scopus 로고    scopus 로고
    • A murine model of isolated cardiac steatosis leads to cardiomyopathy
    • F
    • Glenn D.J., Wang F., Nishimoto M., Cruz M.C., Uchida Y., Holleran W.M., et al. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension Feb 2011, 57(2):216-222.
    • (2011) Hypertension , vol.57 , Issue.2 , pp. 216-222
    • Glenn, D.J.1    Wang, F.2    Nishimoto, M.3    Cruz, M.C.4    Uchida, Y.5    Holleran, W.M.6
  • 25
    • 54249093047 scopus 로고    scopus 로고
    • Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
    • O
    • Park T.S., Hu Y., Noh H.L., Drosatos K., Okajima K., Buchanan J., et al. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res Oct 2008, 49(10):2101-2112.
    • (2008) J Lipid Res , vol.49 , Issue.10 , pp. 2101-2112
    • Park, T.S.1    Hu, Y.2    Noh, H.L.3    Drosatos, K.4    Okajima, K.5    Buchanan, J.6
  • 26
    • 7744234747 scopus 로고    scopus 로고
    • Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
    • N
    • Sharma S., Adrogue J.V., Golfman L., Uray I., Lemm J., Youker K., et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J Nov 2004, 18(14):1692-1700.
    • (2004) FASEB J , vol.18 , Issue.14 , pp. 1692-1700
    • Sharma, S.1    Adrogue, J.V.2    Golfman, L.3    Uray, I.4    Lemm, J.5    Youker, K.6
  • 27
    • 34347352169 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy revisited
    • J 26
    • Boudina S., Abel E.D. Diabetic cardiomyopathy revisited. Circulation Jun 26 2007, 115(25):3213-3223.
    • (2007) Circulation , vol.115 , Issue.25 , pp. 3213-3223
    • Boudina, S.1    Abel, E.D.2
  • 28
    • 0033574265 scopus 로고    scopus 로고
    • Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death
    • M 16
    • Mathur A., Sims H.F., Gopalakrishnan D., Gibson B., Rinaldo P., Vockley J., et al. Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death. Circulation Mar 16 1999, 99(10):1337-1343.
    • (1999) Circulation , vol.99 , Issue.10 , pp. 1337-1343
    • Mathur, A.1    Sims, H.F.2    Gopalakrishnan, D.3    Gibson, B.4    Rinaldo, P.5    Vockley, J.6
  • 31
    • 0037199390 scopus 로고    scopus 로고
    • Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure
    • J 30
    • Osorio J.C., Stanley W.C., Linke A., Castellari M., Diep Q.N., Panchal A.R., et al. Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation Jul 30 2002, 106(5):606-612.
    • (2002) Circulation , vol.106 , Issue.5 , pp. 606-612
    • Osorio, J.C.1    Stanley, W.C.2    Linke, A.3    Castellari, M.4    Diep, Q.N.5    Panchal, A.R.6
  • 33
    • 0029800177 scopus 로고    scopus 로고
    • Fatty acid oxidation enzyme gene expression is downregulated in the failing heart
    • D 1
    • Sack M.N., Rader T.A., Park S., Bastin J., McCune S.A., Kelly D.P. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation Dec 1 1996, 94(11):2837-2842.
    • (1996) Circulation , vol.94 , Issue.11 , pp. 2837-2842
    • Sack, M.N.1    Rader, T.A.2    Park, S.3    Bastin, J.4    McCune, S.A.5    Kelly, D.P.6
  • 35
    • 0035896205 scopus 로고    scopus 로고
    • Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction
    • M 16
    • Ide T., Tsutsui H., Hayashidani S., Kang D., Suematsu N., Nakamura K., et al. Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ Res Mar 16 2001, 88(5):529-535.
    • (2001) Circ Res , vol.88 , Issue.5 , pp. 529-535
    • Ide, T.1    Tsutsui, H.2    Hayashidani, S.3    Kang, D.4    Suematsu, N.5    Nakamura, K.6
  • 36
    • 0033588198 scopus 로고    scopus 로고
    • Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium
    • A 20
    • Ide T., Tsutsui H., Kinugawa S., Utsumi H., Kang D., Hattori N., et al. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ Res Aug 20 1999, 85(4):357-363.
    • (1999) Circ Res , vol.85 , Issue.4 , pp. 357-363
    • Ide, T.1    Tsutsui, H.2    Kinugawa, S.3    Utsumi, H.4    Kang, D.5    Hattori, N.6
  • 37
    • 0037132631 scopus 로고    scopus 로고
    • Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression
    • D 18
    • Scheubel R.J., Tostlebe M., Simm A., Rohrbach S., Prondzinsky R., Gellerich F.N., et al. Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression. J Am Coll Cardiol Dec 18 2002, 40(12):2174-2181.
    • (2002) J Am Coll Cardiol , vol.40 , Issue.12 , pp. 2174-2181
    • Scheubel, R.J.1    Tostlebe, M.2    Simm, A.3    Rohrbach, S.4    Prondzinsky, R.5    Gellerich, F.N.6
  • 38
    • 59449110495 scopus 로고    scopus 로고
    • Metabolic remodelling of the failing heart: beneficial or detrimental?
    • F 15
    • van Bilsen M., van Nieuwenhoven F.A., van der Vusse G.J. Metabolic remodelling of the failing heart: beneficial or detrimental?. Cardiovasc Res Feb 15 2009, 81(3):420-428.
    • (2009) Cardiovasc Res , vol.81 , Issue.3 , pp. 420-428
    • van Bilsen, M.1    van Nieuwenhoven, F.A.2    van der Vusse, G.J.3
  • 39
    • 35848955451 scopus 로고    scopus 로고
    • Return to the fetal gene program protects the stressed heart: a strong hypothesis
    • D
    • Rajabi M., Kassiotis C., Razeghi P., Taegtmeyer H. Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev Dec 2007, 12(3-4):331-343.
    • (2007) Heart Fail Rev , vol.12 , Issue.3-4 , pp. 331-343
    • Rajabi, M.1    Kassiotis, C.2    Razeghi, P.3    Taegtmeyer, H.4
  • 40
  • 42
    • 36849040149 scopus 로고    scopus 로고
    • Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
    • D
    • Neglia D., De Caterina A., Marraccini P., Natali A., Ciardetti M., Vecoli C., et al. Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol Dec 2007, 293(6):H3270-H3278.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , Issue.6
    • Neglia, D.1    De Caterina, A.2    Marraccini, P.3    Natali, A.4    Ciardetti, M.5    Vecoli, C.6
  • 43
    • 0028144326 scopus 로고
    • Total-body and myocardial substrate oxidation in congestive heart failure
    • F
    • Paolisso G., Gambardella A., Galzerano D., D'Amore A., Rubino P., Verza M., et al. Total-body and myocardial substrate oxidation in congestive heart failure. Metabolism Feb 1994, 43(2):174-179.
    • (1994) Metabolism , vol.43 , Issue.2 , pp. 174-179
    • Paolisso, G.1    Gambardella, A.2    Galzerano, D.3    D'Amore, A.4    Rubino, P.5    Verza, M.6
  • 44
    • 0035933194 scopus 로고    scopus 로고
    • Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure
    • M 22
    • Wallhaus T.R., Taylor M., DeGrado T.R., Russell D.C., Stanko P., Nickles R.J., et al. Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure. Circulation May 22 2001, 103(20):2441-2446.
    • (2001) Circulation , vol.103 , Issue.20 , pp. 2441-2446
    • Wallhaus, T.R.1    Taylor, M.2    DeGrado, T.R.3    Russell, D.C.4    Stanko, P.5    Nickles, R.J.6
  • 45
    • 0035136262 scopus 로고    scopus 로고
    • An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure
    • J
    • Taylor M., Wallhaus T.R., Degrado T.R., Russell D.C., Stanko P., Nickles R.J., et al. An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure. J Nucl Med Jan 2001, 42(1):55-62.
    • (2001) J Nucl Med , vol.42 , Issue.1 , pp. 55-62
    • Taylor, M.1    Wallhaus, T.R.2    Degrado, T.R.3    Russell, D.C.4    Stanko, P.5    Nickles, R.J.6
  • 46
    • 3042758687 scopus 로고    scopus 로고
    • Myocardial perfusion reserve and oxidative metabolism contribute to exercise capacity in patients with dilated cardiomyopathy
    • A
    • Stolen K.Q., Kemppainen J., Kalliokoski K.K., Hallsten K., Luotolahti M., Karanko H., et al. Myocardial perfusion reserve and oxidative metabolism contribute to exercise capacity in patients with dilated cardiomyopathy. J Card Fail Apr 2004, 10(2):132-140.
    • (2004) J Card Fail , vol.10 , Issue.2 , pp. 132-140
    • Stolen, K.Q.1    Kemppainen, J.2    Kalliokoski, K.K.3    Hallsten, K.4    Luotolahti, M.5    Karanko, H.6
  • 47
    • 70449591256 scopus 로고    scopus 로고
    • Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling
    • Funada J., Betts T.R., Hodson L., Humphreys S.M., Timperley J., Frayn K.N., et al. Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling. PLoS One 2009, 4(10):e7533.
    • (2009) PLoS One , vol.4 , Issue.10
    • Funada, J.1    Betts, T.R.2    Hodson, L.3    Humphreys, S.M.4    Timperley, J.5    Frayn, K.N.6
  • 48
    • 65349161591 scopus 로고    scopus 로고
    • Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion
    • A 7
    • Turer A.T., Stevens R.D., Bain J.R., Muehlbauer M.J., van der Westhuizen J., Mathew J.P., et al. Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. Circulation Apr 7 2009, 119(13):1736-1746.
    • (2009) Circulation , vol.119 , Issue.13 , pp. 1736-1746
    • Turer, A.T.1    Stevens, R.D.2    Bain, J.R.3    Muehlbauer, M.J.4    van der Westhuizen, J.5    Mathew, J.P.6
  • 51
    • 84856073205 scopus 로고    scopus 로고
    • Metabolomics and cardiovascular biomarker discovery
    • J
    • Rhee E.P., Gerszten R.E. Metabolomics and cardiovascular biomarker discovery. Clin Chem Jan 2012, 58(1):139-147.
    • (2012) Clin Chem , vol.58 , Issue.1 , pp. 139-147
    • Rhee, E.P.1    Gerszten, R.E.2
  • 52
    • 77954743140 scopus 로고    scopus 로고
    • Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure
    • M
    • Kato T., Niizuma S., Inuzuka Y., Kawashima T., Okuda J., Tamaki Y., et al. Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure. Circ Heart Fail May 2010, 3(3):420-430.
    • (2010) Circ Heart Fail , vol.3 , Issue.3 , pp. 420-430
    • Kato, T.1    Niizuma, S.2    Inuzuka, Y.3    Kawashima, T.4    Okuda, J.5    Tamaki, Y.6
  • 53
    • 64249123194 scopus 로고    scopus 로고
    • Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy
    • M 27
    • Pound K.M., Sorokina N., Ballal K., Berkich D.A., Fasano M., Lanoue K.F., et al. Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy. Circ Res Mar 27 2009, 104(6):805-812.
    • (2009) Circ Res , vol.104 , Issue.6 , pp. 805-812
    • Pound, K.M.1    Sorokina, N.2    Ballal, K.3    Berkich, D.A.4    Fasano, M.5    Lanoue, K.F.6
  • 54
    • 70049105662 scopus 로고    scopus 로고
    • Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein
    • J
    • Andreadou I., Papaefthimiou M., Zira A., Constantinou M., Sigala F., Skaltsounis A.L., et al. Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein. NMR Biomed Jul 2009, 22(6):585-592.
    • (2009) NMR Biomed , vol.22 , Issue.6 , pp. 585-592
    • Andreadou, I.1    Papaefthimiou, M.2    Zira, A.3    Constantinou, M.4    Sigala, F.5    Skaltsounis, A.L.6
  • 55
    • 81155137578 scopus 로고    scopus 로고
    • Potential biomarkers in mouse myocardium of doxorubicin-induced cardiomyopathy: a metabonomic method and its application
    • Tan G., Lou Z., Liao W., Zhu Z., Dong X., Zhang W., et al. Potential biomarkers in mouse myocardium of doxorubicin-induced cardiomyopathy: a metabonomic method and its application. PLoS One 2011, 6(11):e27683.
    • (2011) PLoS One , vol.6 , Issue.11
    • Tan, G.1    Lou, Z.2    Liao, W.3    Zhu, Z.4    Dong, X.5    Zhang, W.6
  • 57
    • 79953740856 scopus 로고    scopus 로고
    • Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy
    • M
    • Alexander D., Lombardi R., Rodriguez G., Mitchell M.M., Marian A.J. Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy. Eur J Clin Invest May 2011, 41(5):527-538.
    • (2011) Eur J Clin Invest , vol.41 , Issue.5 , pp. 527-538
    • Alexander, D.1    Lombardi, R.2    Rodriguez, G.3    Mitchell, M.M.4    Marian, A.J.5
  • 58
    • 79651471472 scopus 로고    scopus 로고
    • (1)H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure
    • M
    • Kang S.M., Park J.C., Shin M.J., Lee H., Oh J., Ryu do H., et al. (1)H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clin Biochem Mar 2011, 44(4):293-299.
    • (2011) Clin Biochem , vol.44 , Issue.4 , pp. 293-299
    • Kang, S.M.1    Park, J.C.2    Shin, M.J.3    Lee, H.4    Oh, J.5    Ryu do, H.6
  • 59
    • 0026317455 scopus 로고
    • Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate
    • D
    • Russell R.R., Taegtmeyer H. Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate. Am J Physiol Dec 1991, 261(6 Pt 2):H1756-H1762.
    • (1991) Am J Physiol , vol.261 , Issue.6 PART 2
    • Russell, R.R.1    Taegtmeyer, H.2
  • 60
    • 0026065784 scopus 로고
    • Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate
    • F
    • Russell R.R., Taegtmeyer H. Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate. J Clin Invest Feb 1991, 87(2):384-390.
    • (1991) J Clin Invest , vol.87 , Issue.2 , pp. 384-390
    • Russell, R.R.1    Taegtmeyer, H.2
  • 61
    • 0028857578 scopus 로고
    • Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate
    • J
    • Russell R.R., Mommessin J.I., Taegtmeyer H. Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate. Am J Physiol Jan 1995, 268(1 Pt 2):H441-H447.
    • (1995) Am J Physiol , vol.268 , Issue.1 PART 2
    • Russell, R.R.1    Mommessin, J.I.2    Taegtmeyer, H.3
  • 62
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • J
    • Stanley W.C., Recchia F.A., Lopaschuk G.D. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev Jul 2005, 85(3):1093-1129.
    • (2005) Physiol Rev , vol.85 , Issue.3 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 63
    • 38349100117 scopus 로고    scopus 로고
    • Combined metabolomic and proteomic analysis of human atrial fibrillation
    • F 5
    • Mayr M., Yusuf S., Weir G., Chung Y.L., Mayr U., Yin X., et al. Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol Feb 5 2008, 51(5):585-594.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.5 , pp. 585-594
    • Mayr, M.1    Yusuf, S.2    Weir, G.3    Chung, Y.L.4    Mayr, U.5    Yin, X.6
  • 64
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • A
    • Wang T.J., Larson M.G., Vasan R.S., Cheng S., Rhee E.P., McCabe E., et al. Metabolite profiles and the risk of developing diabetes. Nat Med Apr 2011, 17(4):448-453.
    • (2011) Nat Med , vol.17 , Issue.4 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3    Cheng, S.4    Rhee, E.P.5    McCabe, E.6
  • 65
    • 77953667219 scopus 로고    scopus 로고
    • Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
    • A
    • Shah S.H., Bain J.R., Muehlbauer M.J., Stevens R.D., Crosslin D.R., Haynes C., et al. Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ Cardiovasc Genet Apr 2010, 3(2):207-214.
    • (2010) Circ Cardiovasc Genet , vol.3 , Issue.2 , pp. 207-214
    • Shah, S.H.1    Bain, J.R.2    Muehlbauer, M.J.3    Stevens, R.D.4    Crosslin, D.R.5    Haynes, C.6
  • 66
    • 79955387227 scopus 로고    scopus 로고
    • Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss
    • [80re2] A 27
    • Laferrere B., Reilly D., Arias S., Swerdlow N., Gorroochurn P., Bawa B., et al. Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med Apr 27 2011, 3(80). [80re2].
    • (2011) Sci Transl Med , vol.3 , Issue.80
    • Laferrere, B.1    Reilly, D.2    Arias, S.3    Swerdlow, N.4    Gorroochurn, P.5    Bawa, B.6
  • 67
    • 79953329970 scopus 로고    scopus 로고
    • Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    • A
    • Rhee E.P., Cheng S., Larson M.G., Walford G.A., Lewis G.D., McCabe E., et al. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest Apr 2011, 121(4):1402-1411.
    • (2011) J Clin Invest , vol.121 , Issue.4 , pp. 1402-1411
    • Rhee, E.P.1    Cheng, S.2    Larson, M.G.3    Walford, G.A.4    Lewis, G.D.5    McCabe, E.6
  • 69
    • 0037316670 scopus 로고    scopus 로고
    • Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
    • F
    • Yagyu H., Chen G., Yokoyama M., Hirata K., Augustus A., Kako Y., et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest Feb 2003, 111(3):419-426.
    • (2003) J Clin Invest , vol.111 , Issue.3 , pp. 419-426
    • Yagyu, H.1    Chen, G.2    Yokoyama, M.3    Hirata, K.4    Augustus, A.5    Kako, Y.6
  • 70
    • 0036143320 scopus 로고    scopus 로고
    • The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    • J
    • Finck B.N., Lehman J.J., Leone T.C., Welch M.J., Bennett M.J., Kovacs A., et al. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest Jan 2002, 109(1):121-130.
    • (2002) J Clin Invest , vol.109 , Issue.1 , pp. 121-130
    • Finck, B.N.1    Lehman, J.J.2    Leone, T.C.3    Welch, M.J.4    Bennett, M.J.5    Kovacs, A.6
  • 71
    • 34948910262 scopus 로고    scopus 로고
    • Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice
    • Son N.H., Park T.S., Yamashita H., Yokoyama M., Huggins L.A., Okajima K., et al. Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice. J Clin Invest 2007 Oct, 117(10):2791-2801.
    • (2007) J Clin Invest , vol.117 , Issue.10 , pp. 2791-2801
    • Son, N.H.1    Park, T.S.2    Yamashita, H.3    Yokoyama, M.4    Huggins, L.A.5    Okajima, K.6
  • 72
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • M 4
    • Listenberger L.L., Ory D.S., Schaffer J.E. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem May 4 2001, 276(18):14890-14895.
    • (2001) J Biol Chem , vol.276 , Issue.18 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 73
    • 33845575826 scopus 로고    scopus 로고
    • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    • D
    • Borradaile N.M., Han X., Harp J.D., Gale S.E., Ory D.S., Schaffer J.E. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res Dec 2006, 47(12):2726-2737.
    • (2006) J Lipid Res , vol.47 , Issue.12 , pp. 2726-2737
    • Borradaile, N.M.1    Han, X.2    Harp, J.D.3    Gale, S.E.4    Ory, D.S.5    Schaffer, J.E.6
  • 74
    • 77957846150 scopus 로고    scopus 로고
    • PPARgamma-induced cardiolipotoxicity in mice is ameliorated by PPARalpha deficiency despite increases in fatty acid oxidation
    • O
    • Son N.H., Yu S., Tuinei J., Arai K., Hamai H., Homma S., et al. PPARgamma-induced cardiolipotoxicity in mice is ameliorated by PPARalpha deficiency despite increases in fatty acid oxidation. J Clin Invest Oct 2010, 120(10):3443-3454.
    • (2010) J Clin Invest , vol.120 , Issue.10 , pp. 3443-3454
    • Son, N.H.1    Yu, S.2    Tuinei, J.3    Arai, K.4    Hamai, H.5    Homma, S.6
  • 75
    • 33644874718 scopus 로고    scopus 로고
    • Metabolomic identification of novel biomarkers of myocardial ischemia
    • D 20
    • Sabatine M.S., Liu E., Morrow D.A., Heller E., McCarroll R., Wiegand R., et al. Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation Dec 20 2005, 112(25):3868-3875.
    • (2005) Circulation , vol.112 , Issue.25 , pp. 3868-3875
    • Sabatine, M.S.1    Liu, E.2    Morrow, D.A.3    Heller, E.4    McCarroll, R.5    Wiegand, R.6
  • 77
    • 55849144043 scopus 로고    scopus 로고
    • Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury
    • O
    • Lewis G.D., Wei R., Liu E., Yang E., Shi X., Martinovic M., et al. Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest Oct 2008, 118(10):3503-3512.
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3503-3512
    • Lewis, G.D.1    Wei, R.2    Liu, E.3    Yang, E.4    Shi, X.5    Martinovic, M.6
  • 78
    • 79952837133 scopus 로고    scopus 로고
    • Assessment of metabolic phenotypes in patients with non-ischemic dilated cardiomyopathy undergoing cardiac resynchronization therapy
    • D
    • Obrzut S., Tiongson J., Jamshidi N., Phan H.M., Hoh C., Birgersdotter-Green U. Assessment of metabolic phenotypes in patients with non-ischemic dilated cardiomyopathy undergoing cardiac resynchronization therapy. J Cardiovasc Transl Res Dec 2010, 3(6):643-651.
    • (2010) J Cardiovasc Transl Res , vol.3 , Issue.6 , pp. 643-651
    • Obrzut, S.1    Tiongson, J.2    Jamshidi, N.3    Phan, H.M.4    Hoh, C.5    Birgersdotter-Green, U.6
  • 79
    • 78649692853 scopus 로고    scopus 로고
    • On getting there from here
    • D 3
    • McKnight S.L. On getting there from here. Science Dec 3 2010, 330(6009):1338-1339.
    • (2010) Science , vol.330 , Issue.6009 , pp. 1338-1339
    • McKnight, S.L.1
  • 80
    • 79951837511 scopus 로고    scopus 로고
    • Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry
    • F
    • Li W., Bian F., Chaudhuri P., Mao X., Brunengraber H., Yu X. Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry. NMR Biomed Feb 2011, 24(2):176-187.
    • (2011) NMR Biomed , vol.24 , Issue.2 , pp. 176-187
    • Li, W.1    Bian, F.2    Chaudhuri, P.3    Mao, X.4    Brunengraber, H.5    Yu, X.6
  • 81
    • 0027180438 scopus 로고
    • Effects of amino acids on substrate selection, anaplerosis, and left ventricular function in the ischemic reperfused rat heart
    • A
    • Jessen M.E., Kovarik T.E., Jeffrey F.M., Sherry A.D., Storey C.J., Chao R.Y., et al. Effects of amino acids on substrate selection, anaplerosis, and left ventricular function in the ischemic reperfused rat heart. J Clin Invest Aug 1993, 92(2):831-839.
    • (1993) J Clin Invest , vol.92 , Issue.2 , pp. 831-839
    • Jessen, M.E.1    Kovarik, T.E.2    Jeffrey, F.M.3    Sherry, A.D.4    Storey, C.J.5    Chao, R.Y.6
  • 82
    • 0030448394 scopus 로고    scopus 로고
    • Effects of glutamate and aspartate on myocardial substrate oxidation during potassium arrest
    • v
    • Reed M.K., Barak C., Malloy C.R., Maniscalco S.P., Jessen M.E. Effects of glutamate and aspartate on myocardial substrate oxidation during potassium arrest. J Thorac Cardiovasc Surg Dec 1996, 112(6):1651-1660.
    • (1996) J Thorac Cardiovasc Surg , vol.112 , Issue.6 , pp. 1651-1660
    • Reed, M.K.1    Barak, C.2    Malloy, C.R.3    Maniscalco, S.P.4    Jessen, M.E.5
  • 83
    • 0029897429 scopus 로고    scopus 로고
    • Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by 13C isotopomer analysis and O2 consumption in the heart
    • M
    • Malloy C.R., Jones J.G., Jeffrey F.M., Jessen M.E., Sherry A.D. Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by 13C isotopomer analysis and O2 consumption in the heart. MAGMA Mar 1996, 4(1):35-46.
    • (1996) MAGMA , vol.4 , Issue.1 , pp. 35-46
    • Malloy, C.R.1    Jones, J.G.2    Jeffrey, F.M.3    Jessen, M.E.4    Sherry, A.D.5
  • 84
    • 82755168823 scopus 로고    scopus 로고
    • Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
    • N 22
    • Merritt M.E., Harrison C., Sherry A.D., Malloy C.R., Burgess S.C. Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc Natl Acad Sci U S A Nov 22 2011, 108(47):19084-19089.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.47 , pp. 19084-19089
    • Merritt, M.E.1    Harrison, C.2    Sherry, A.D.3    Malloy, C.R.4    Burgess, S.C.5
  • 85
    • 55749109847 scopus 로고    scopus 로고
    • Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3
    • N
    • Merritt M.E., Harrison C., Storey C., Sherry A.D., Malloy C.R. Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3. Magn Reson Med Nov 2008, 60(5):1029-1036.
    • (2008) Magn Reson Med , vol.60 , Issue.5 , pp. 1029-1036
    • Merritt, M.E.1    Harrison, C.2    Storey, C.3    Sherry, A.D.4    Malloy, C.R.5
  • 86
    • 84860787353 scopus 로고    scopus 로고
    • The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study
    • M
    • Schroeder M.A., Atherton H.J., Dodd M.S., Lee P., Cochlin L.E., Radda G.K., et al. The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. Circ Cardiovasc Imaging Mar 2012, 5(2):201-209.
    • (2012) Circ Cardiovasc Imaging , vol.5 , Issue.2 , pp. 201-209
    • Schroeder, M.A.1    Atherton, H.J.2    Dodd, M.S.3    Lee, P.4    Cochlin, L.E.5    Radda, G.K.6
  • 87
    • 80052854052 scopus 로고    scopus 로고
    • Could 13C MRI assist clinical decision-making for patients with heart disease?
    • O
    • Malloy C.R., Merritt M.E., Sherry A.D. Could 13C MRI assist clinical decision-making for patients with heart disease?. NMR Biomed Oct 2011, 24(8):973-979.
    • (2011) NMR Biomed , vol.24 , Issue.8 , pp. 973-979
    • Malloy, C.R.1    Merritt, M.E.2    Sherry, A.D.3


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