Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 2 47-2, 2003, Pages

  Boehm, Ernest ^a   Chan, Sharon ^b   Monfared, Mina ^b   Wallimann, Theo ^b   Clarke, Kieran ^b   Neubauer, Stefan ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NONE

Author keywords

Cell surface biotinylation; Creatine depletion; Creatine feeding; Creatine transport(er); Isolated perfused heart

Indexed keywords

CARRIER PROTEIN; CREATINE; CREATINE TRANSPORTER; GUANIDINOPROPIONIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART MUSCLE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; TRANSPORT KINETICS;

EID: 0037306641     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00259.2002     Document Type: Article

References (31)

1. Balsom PD, Soderlund K, and Ekblom B. Creatine in humans with special reference to creatine supplementation. Sports Med 18: 268-280, 1994.
2. Bessman SP and Carpenter CL. The creatine-creatine phosphate energy shuttle. Annu Rev Biochem 54: 831-862, 1985.
3. Bessman SP and Geiger PJ. Transport of energy in muscle: the phosphorylcreatine shuttle. Science 211: 448-452, 1982.
4. Bloch K, Schoenheimer R, and Rittenberg D. Rate of formation and disappearance of body creatine in normal animals. J Biol Chem 138: 155-166, 1941.
5. Boehm EA, Chan S, Monfared M, Zhang J, Liu J, and Neubauer S. Simultaneous decreases in the creatine transporter, creatine content and creatine kinase in an experimental dog model of heart failure (Abstract). Circulation 104: II-119, 2001.
6. Daniels GM and Amara SG. Selective labeling of neurotransmitter transporters at the cell surface. Methods Enzymol 296: 307-318, 1998.
7. Dodd JR, Zheng T, and Christie DL. Creatine accumulation and exchange by HEK293 cells stably expressing high levels of a creatine transporter. Biochim Biophys Acta 1472: 128-136, 1999.
8. Fitch CD, Shields RP, Payne WF, and Dacus JM. Creatine metabolism in skeletal muscle. 3. Specificity of the creatine entry process. J Biol Chem 243: 2024-2027, 1968.
9. Garcia-Delgado M, Peral MJ, Cano M, Calonge ML, and Ilundain AA. Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex. J Am Soc Nephrol 12: 1819-1825, 2001.
10. Guerrero-Ontiveros ML and Wallimann T. Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: down-regulation of the expression of creatine transporter isoforms in skeletal muscle. Mol Cell Biochem 184: 427-437, 1998.
11. Harris RC, Soderlund K, and Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Colch) 83: 367-374, 1992.
12. Horn M, Frantz S, Remkes H, Laser A, Urban B, Mettenleiter A, Schnackerz K, and Neubauer S. Effects of chronic dietary creatine feeding on cardiac energy metabolism and on creatine content in heart, skeletal muscle, brain, liver and kidney. J Mol Cell Cardiol 30: 277-284, 1998.
13. Loike JD, Zalutsky DL, Kaback E, Miranda AF, and Silverstein SC. Extracellular creatine regulates creatine transport in rat and human-muscle cells. Proc Natl Acad Sci USA 85: 807-811, 1988.
14. Lowry OH, Rosebrough MJ, Farr AL, and Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
15. Mekhfi H, Hoerter J, Lauer C, Wisnewsky C, Schwartz K, and Ventura Clapier R. Myocardial adaptation to creatine deficiency in rats fed with β-guanidinopropionic acid, a creatine analogue. Am J Physiol Heart Circ Physiol 258: H1151-H1158, 1990.
16. Moller A and Hamprecht B. Creatine transport in cultured cells of rat and mouse brain. J Neurochem 52: 544-550, 1989.
17. Neubauer S, Horn M, Naumann A, Tian R, Hu K, Laser M, Friedrich J, Gaudron P, Schnackerz K, Ingwall JS, and Ertl G. Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest 95: 1092-1100, 1995.
18. Neubauer S, Hu K, Horn M, Remkes H, Hoffmann KD, Schmidt C, Schmidt TJ, Schnackerz K, and Ertl G. Functional and energetic consequences of chronic myocardial creatine depletion by beta-guanidinopropionate in perfused hearts and in intact rats. J Mol Cell Cardiol 31: 1845-1855, 1999.
19. Neubauer S, Remkes H, Spindler M, Horn M, Wiesmann F, Prestle J, Walzel B, Ertl G, Hasenfuss G, and Wallimann T. Downregulation of the Na+-creatine cotransporter in failing human myocardium and in experimental heart failure. Circulation 100: 1847-1850, 1999.
20. Ogorman E, Beutner G, Wallimann T, and Brdiczka D. Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. Biochim Biophys Acta 1276: 161-170, 1996.
21. Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, and Carling D. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J 17: 1688-1699, 1998.
22. Powell T, Noma A, and Severs NJ. Isolation and culture of adult cardiac myocytes. In: Cell Biology: A Laboratory Handbook (2nd ed.). New York: Academic, 1998, p. 125-132.
23. Seppet EK, Adoyaan AJ, Kallikorm AP, Chernousova GB, Lyulina NV, Sharov VG, Severin VV, Popovich MI, and Saks VA. Hormone regulation of cardiac energy metabolism. I. Creatine transport across cell membranes of euthyroid and hyperthyroid rat heart. Biochem Med 34: 267-279, 1985.
24. Shoubridge EA, Challiss RA, Hayes DJ, and Radda GK. Biochemical adaptation in the skeletal muscle of rats depleted of creatine with the substrate analogue beta-guanidinopropionic acid. Biochem J 232: 125-131, 1985.
25. Snow RJ and Murphy RM. Creatine and the creatine transporter: a review. Mol Cell Biochem 224: 169-181, 2001.
26. Stephan MM, Chen MA, Penado KM, and Rudnick G. An extracellular loop region of the serotonin transporter may be involved in the translocation mechanism. Biochemistry 36: 1322-1328, 1997.
27. Wallimann T, Wyss M, Brdiczka D, Nicolay K, and Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the "phosphocreatine circuit" for cellular energy homeostasis. Biochem J 281: 21-40, 1992.
28. Walzel B, Speer O, Boehm E, Kristiansen S, Chan S, Clarke K, Magyar JP, Richter EA, and Wallimann T. New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle. Am J Physiol Endocrinol Metab 283: E390-E401, 2002.
29. Willott CA, Young ME, Leighton B, Kemp GJ, Boehm EA, Radda GK, and Clarke K. Creatine uptake in isolated soleus muscle: kinetics and dependence on sodium, but not on insulin. Acta Physiol Scand 166: 99-104, 1999.
30. Wyss M and Kaddurah Daouk R. Creatine and creatinine metabolism. Physiol Rev 80: 1107-1213, 2000.
31. Zweier JL, Jacobus WE, Korecky B, and Brandejs Barry Y. Bioenergetic consequences of cardiac phosphocreatine depletion induced by creatine analogue feeding. J Biol Chem 266: 20296-20304, 1991.