Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry

NMR in Biomedicine

Volumn 24, Issue 2, 2011, Pages 176-187

  Li, Wei ^a   Bian, Fang ^a   Chaudhuri, Priyanjana ^a   Mao, Xian ^b   Brunengraber, Henri ^c   Yu, Xin ^a,b  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

13C isotopomer; Anaplerosis; Metabolic modeling; Metabolomics; Stable isotope

Indexed keywords

13C ISOTOPOMER; ANAPLEROSIS; METABOLIC MODELING; METABOLOMICS; STABLE ISOTOPE;

GLUCOSE; ISOMERS; ISOTOPES; MASS SPECTROMETRY; METABOLISM; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

SUBSTRATES;

2 OXOGLUTARIC ACID; ALANINE; CARBON 13; GLUCOSE; GLUTAMIC ACID; LACTIC ACID; MALIC ACID; PALMITIC ACID; PROPIONYL COENZYME A; SUCCINIC ACID; TRICARBOXYLIC ACID;

ACCURACY; AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; GAS CHROMATOGRAPHY; GLUCOSE UTILIZATION; HEART MUSCLE METABOLISM; ISOLATED HEART; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; MATHEMATICAL MODEL; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RADIOISOTOPE DISTRIBUTION; RAT;

ALANINE; ANIMALS; CARBON ISOTOPES; CITRIC ACID CYCLE; COMPUTER SIMULATION; LACTIC ACID; MALE; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MYOCARDIUM; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; VENTRICULAR FUNCTION;

RATTUS;

EID: 79951837511     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1569     Document Type: Article

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