Interaction between maternal and postnatal high fat diet leads to a greater risk of myocardial dysfunction in offspring via enhanced lipotoxicity, IRS-1 serine phosphorylation and mitochondrial defects

Journal of Molecular and Cellular Cardiology

Volumn 55, Issue 1, 2013, Pages 117-129

  Turdi, Subat ^a   Ge, Wei ^a,b   Hu, Nan ^a   Bradley, Katherine M ^a   Wang, Xiaoming ^b   Ren, Jun ^a  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cardiac function; Fetal programming; High fat; Insulin; Lipotoxicity; Mitochondria

Indexed keywords

ACYL COENZYME A DESATURASE; ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; CALCINEURIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MYOSIN HEAVY CHAIN BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN TYROSINE PHOSPHATASE 1B; REACTIVE OXYGEN METABOLITE; SERINE; TRANSCRIPTION FACTOR GATA 4;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DYSLIPIDEMIA; ECHOCARDIOGRAPHY; FEMALE; GLUCOSE INTOLERANCE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; HISTOLOGY; INSULIN RESISTANCE; LACTATION; LIPID DIET; LIPOTOXICITY; LOW FAT DIET; MALE; MATERNAL NUTRITION; MOUSE; MYOCARDIAL DISEASE; MYOCARDIAL DYSFUNCTION; NONHUMAN; OBESITY; PERINATAL PERIOD; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ADIPOCYTES; ADULT; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CALCIUM; CALCIUM-BINDING PROTEINS; CARDIOMEGALY; DIET, HIGH-FAT; ECHOCARDIOGRAPHY; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HEART; HUMANS; HYPERTROPHY; INSULIN RECEPTOR SUBSTRATE PROTEINS; LIPID METABOLISM; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MYOCARDIAL CONTRACTION; MYOCARDIUM; ORGAN SIZE; PHOSPHORYLATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER;

MUS;

EID: 84872675112     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.12.007     Document Type: Article

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