Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice

Journal of Endocrinology

Volumn 188, Issue 1, 2006, Pages 25-36

  Dong, F ^a   Zhang, X ^a   Yang, X ^a   Esberg, L B ^a   Yang, H ^a   Zhang, Z ^a   Culver, B ^a   Ren, J ^a  

^a UNIVERSITY OF WYOMING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; LEPTIN; LEPTIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STIMULATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; GENE MUTATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; HYPOPROTEINEMIA; LEAN BODY WEIGHT; LIPID DIET; MALE; MITOCHONDRION SWELLING; MOUSE; MOUSE STRAIN; MYOCARDIAL DISEASE; NONHUMAN; OBESITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CALCIUM; CELL SEPARATION; HEART VENTRICLES; LEPTIN; MALE; MICE; MICE, OBESE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; OBESITY; SUPEROXIDES;

EID: 31544477999     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06241     Document Type: Article

References (28)

1. Aizawa-Abe M, Ogawa Y, Masuzaki H, Ebihara K, Satoh N, Iwai H, Matsuoka N, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y & Nakao K 2000 Pathophysiological role of leptin in obesity-related hypertension. Journal of Clinical Investigation 105 1243-1252.
2. Barouch LA, Berkowitz DE, Harrison RW, O'Donnell CP & Hare JM 2003 Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 108 754-759.
3. Choi DJ & Rockman HA 1993 Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure. Cellular Biochemistry and Biophysics 31 321-329.
4. Coleman DL 1978 Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14 141-148.
5. Dobrian AD, Davies MJ, Prewitt RL & Lauterio TJ 2000 Development of hypertension in a rat model of diet-induced obesity. Hypertension 35 1009-1015.
6. Dobrian AD, Davies MJ, Schriver SD, Lauterio TJ & Prewitt RL 2001 Oxidative stress in a rat model of obesity-induced hypertension. Hypertension 37 554-560.
7. Duan J, Zhang HY, Adkins SD, Ren BH, Norby FL, Zhang X, Benoit JN, Epstein PN & Ren J 2003 Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA. American Journal of Physiology: Endocrinology and Metabolism 284 E366-E376.
8. Eckel RH, Barouch WW & Ershow AG 2002 Report of the National Heart, Lung, and Blood Institute - National Institute of Diabetes and Digestive and Kidney Diseases Working Group on the pathophysiology of obesity associated cardiovascular disease. Circulation 103 2923-2928.
9. Giacomelli F & Wiener J 1979 Primary myocardial disease in the diabetic mouse. An ultrastructural study. Laboratory Investigation 40 460-473.
10. Kuo JJ, Jones OB & Hall JE 2003 Chronic cardiovascular and renal actions of leptin during hyperinsulinemia. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 284 R1037-R1042.
11. Li SY, Liu Y, Sigmon VK, McCort A & Ren J 2005 High-fat diet enhances visceral advanced glycation end products, nuclear O-Glc-Nac modification, p38 mitogen-activated protein kinase activation and apoptosis. Diabetes, Obesity and Metabolism 7 448-454.
12. McPherson BC & Yao Z 2001 Morphine mimics preconditioning via free radical signals and mitochondrial K(ATP) channels in myocytes. Circulation 103 290-295.
13. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW & Huffnagle GB 2002 Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. Journal of Immunology 168 4018-4024.
14. Mark AL & Sivitz WI 2002 Uncoupling metabolism and coupling leptin to cardiovascular disease. Arteriosclerosis, Thrombosis and Vascular Biology 22 881-883.
15. Matsumura K, Abe I, Tsuchihashi T & Fujishima M 2000 Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 278 R1314-R1320.
16. Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S & Abel ED 2004 Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 53 2366-2374.
17. Minhas KM, Khan SA, Raju SV, Phan AC, Gonzalez DR, Skaf MW, Lee K, Tejani AD, Saliaris AP, Barouch LA, O'Donnell CP, Emala CW, Berkowitz DE & Hare JM 2005 Leptin repletion restores depressed β-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. Journal of Physiology 565 463-474.
18. Nickola MW, Wold LE, Colligan PB, Wang G-J, Samson WK & Ren J 2000 Leptin attenuates cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Hypertension 36 501-505.
19. Ren J 2004 Leptin and hyperleptinemia - from friend to foe for cardiovascular function. Journal of Endocrinology 181 1-10.
20. Ren J 2005 Lessons from the leptin paradox in cardiac regulation - too much versus too little. Journal of Physiology 565 347.
21. Ren J, Sowers JR, Walsh MF & Brown RA 2000a Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats. American Journal of Physiology: Heart and Circulatory Physiology 279 H1708-H1714.
22. Ren J, Walsh MF, Jefferson L, Natavio M, Ilg KJ, Sowers JR & Brown RA 2000b Basal and ethanol-induced cardiac contractile response in lean and obese Zucker rat hearts. Journal of Biomedical Sciences 7 390-400.
23. Ross SA, Gulve EA & Wang M 2004 Chemistry and biochemistry of type 2 diabetes. Chemistry Review 104 1255-1282.
24. Sethi JK & Vidal-Puig A 2005 Visfatin: the missing link between intra-abdominal obesity and diabetes? Trends in Molecular Medicine 11 344-347.
25. Shirasaka T, Takasaki M & Kannan H 2003 Cardiovascular effects of leptin and orexins. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 284 R639-R651.
26. Sewers JR 1998 Obesity and cardiovascular disease. Clinical Chemistry 44 1821-1825.
27. Winters B, Mo Z, Brooks-Asplund E, Kim S, Shoukas A, Li D, Nyhan D & Berkowitz DE 2000 Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lep(ob)) mice. Journal of Applied Physiology 89 2382-2390.
28. Wold, LE, Relling DP, Duan J, Norby FL & Ren J 2002 Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Hypertension 39 69-74.