Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation

Inflammation and Allergy - Drug Targets

Volumn 7, Issue 4, 2008, Pages 217-223

  Hansen, Wiebke ^a   Westendorf, Astrid M ^a   Buer, Jan ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

CD83; Foxp3; G protein coupled receptor 83; Neuropilin 1; Regulatory T cells; Surface receptor

Indexed keywords

CD83 ANTIGEN; CD83L ANTIGEN; DEC 205 ANTIBODY; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 83; HEMAGGLUTININ; NEUROPILIN 1; RETINOIC ACID; RETROVIRUS VECTOR; T LYMPHOCYTE ANTIGEN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; ANTIGEN; GPR83 PROTEIN, HUMAN; IMMUNOGLOBULIN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INTERACTION; DENDRITIC CELL; DRUG POTENCY; DRUG TARGETING; GENE TARGETING; GENE TRANSFER; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; IN VIVO STUDY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; NONHUMAN; REGULATORY T LYMPHOCYTE; REPEATED DRUG DOSE; REVIEW; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; ANIMAL; DRUG EFFECT; IMMUNOLOGY; PHYSIOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGENS; ANTIGENS, CD; AUTOIMMUNE DISEASES; HUMANS; IMMUNOGLOBULINS; IMMUNOTHERAPY; INFLAMMATION; MEMBRANE GLYCOPROTEINS; NEUROPILIN-1; RECEPTORS, G-PROTEIN-COUPLED; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRETINOIN;

EID: 58249086492     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152808786848360     Document Type: Review

References (58)

1. Sakaguchi, S.; Ono, M.; Setoguchi, R.; Yagi, H.; Hori, S.; Fehervari, Z.; Shimizu, J.; Takahashi, T.; Nomura, T. Foxp3+CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev., 2006, 212, 8.
2. Izcue, A.; Coombes, J.L.; Powrie, F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev., 2006, 212, 256.
3. Fontenot, J.D.; Rudensky, A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol., 2005, 6, 331.
4. von Boehmer. H. Mechanisms of suppression by suppressor T cells. Nat. Immunol., 2005, 6, 338.
5. Fontenot, J.D.; Gavin, M.A.; Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol., 2003, 4, 330.
6. Lanoue, A.; Bona, C.; von Boehmer, H.; Sarukhan, A. Conditions that induce tolerance in mature CD4+ T cells. J. Exp. Med., 1997, 185, 405.
7. Buer, J.; Lanoue, A.; Franzke, A.; Garcia, C.; von Boehmer, H.; Sarukhan, A. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J. Exp. Med., 1998, 187, 177.
8. Hansen, W.; Westendorf, A.M.; Reinwald, S.; Bruder, D.; Deppenmeier, S.; Groebe, L.; Probst-Kepper, M.; Gruber, A. D.; Geffers, R.; Buer, J. Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3-CD25- regulatory T cells. J. Immunol., 2007, 179, 8059.
9. Westendorf, A. M.; Fleissner, D.; Deppenmeier, S.; Gruber, A.D.; Bruder, D.; Hansen, W.; Liblau, R.; Buer, J. Autoimmune-mediated intestinal inflammation-impact and regulation of antigen-specific CD8+ T cells. Gastroenterology, 2006, 131, 510.
10. Apostolou, I.; von Boehmer, H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med., 2004, 199, 1401.
11. Verginis, P.; McLaughlin, K.A.; Wucherpfennig, K.W.; von Boehmer, H.; Apostolou, I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc. Natl. Acad. Sci. USA, 2008, 105, 3479.
12. Kretschmer, K.; Apostolou, I.; Hawiger, D.; Khazaie, K.; Nussenzweig, M.C.; von Boehmer, H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol., 2005, 6, 1219.
13. Bruder, D.; Westendorf, A.M.; Hansen, W.; Prettin, S.; Gruber, A.D.; Qian, Y.; von Boehmer, H.; Mahnke, K.; Buer, J. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes, 2005, 54, 3395.
14. Gorelik, L.; Flavell, R. A. Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol., 2002, 2, 46.
15. Gorelik, L.; Flavell, R. A. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity, 2000, 12, 171.
16. Chen, W.; Jin, W.; Hardegen, N.; Lei, K.J.; Li, L.; Marinos, N.; McGrady, G.; Wahl, S.M. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med., 2003, 198, 1875.
17. Fantini, M.C.; Becker, C.; Tubbe, I.; Nikolaev, A.; Lehr, H.A.; Galle, P.; Neurath, M. F. Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut, 2006, 55, 671.
18. Coombes, J.L.; Siddiqui, K.R.; Arancibia-Carcamo, C.V.; Hall, J.; Sun, C.M.; Belkaid, Y.; Powrie, F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med., 2007, 204, 1757.
19. Sun, C.M.; Hall, J.A.; Blank, R.B.; Bouladoux, N.; Oukka, M.; Mora, J.R.; Belkaid, Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 Treg cells via retinoic acid. J. Exp. Med., 2007, 204, 1775.
20. Benson, M.J.; Pino-Lagos, K.; Rosemblatt, M.; Noelle, R.J. All-trans retinoic acid mediates enhanced Treg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med., 2007, 204, 1765.
21. Nakamura, K.; Kitani, A.; Strober, W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med., 2001, 194, 629.
22. Chen, M.L.; Pittet, M.J.; Gorelik, L.; Flavell, R.A.; Weissleder, R.; von Boehmer, H.; Khazaie, K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc. Natl. Acad. Sci. USA, 2005, 102, 419.
23. Green, E.A.; Gorelik, L.; McGregor, C.M.; Tran, E.H.; Flavell, R.A. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. USA, 2003, 100, 10878.
24. Gil-Guerrero, L.; Dotor, J.; Huibregtse, I.L.; Casares, N.; Lopez-Vazquez, A.B.; Rudilla, F.; Riezu-Boj, J.I.; Lopez-Sagaseta, J.; Hermida, J.; Van, D.S.; Bezunartea, J.; Llopiz, D.; Sarobe, P.; Prieto, J.; Borras-Cuesta, F.; Lasarte, J.J. In Vitro and In Vivo Down-Regulation of Regulatory T Cell Activity with a Peptide Inhibitor of TGF-beta1. J. Immunol., 2008, 181, 126.
25. Kolodkin, A.L.; Levengood, D.V.; Rowe, E.G.; Tai, Y.T.; Giger, R.J.; Ginty, D.D. Neuropilin is a semaphorin III receptor. Cell, 1997, 90, 753.
26. Bruder, D.; Probst-Kepper, M.; Westendorf, A.M.; Geffers, R.; Beissert, S.; Loser, K.; von Boehmer, H.; Buer, J.; Hansen, W. Neuropilin-1: a surface marker of regulatory T cells. Eur. J. Immunol., 2004, 34, 623.
27. Hill, J.A.; Feuerer, M.; Tash, K.; Haxhinasto, S.; Perez, J.; Melamed, R.; Mathis, D.; Benoist, C. Foxp3 transcription-factordependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity, 2007, 27, 786.
28. Delgado, M.; Chorny, A.; Gonzalez-Rey, E.; Ganea, D. Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo. J. Leukoc. Biol., 2005, 78, 1327.
29. Battaglia, A.; Buzzonetti, A.; Monego, G.; Peri, L.; Ferrandina, G.; Fanfani, F.; Scambia, G.; Fattorossi, A. Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer. Immunology, 2008, 123, 129.
30. Corbel, C.; Lemarchandel, V.; Thomas-Vaslin, V.; Pelus, A. S.; Agboton, C.; Romeo, P.H. Neuropilin 1 and CD25 co-regulation during early murine thymic differentiation. Dev. Comp Immunol., 2007, 31, 1082.
31. Tordjman, R.; Lepelletier, Y.; Lemarchandel, V.; Cambot, M.; Gaulard, P.; Hermine, O.; Romeo, P.H. A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat. Immunol., 2002, 3, 477.
32. Sarris, M.; Andersen, K.G.; Randow, F.; Mayr, L.; Betz, A.G. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity, 2008, 28, 402.
33. Tadokoro, C.E.; Shakhar, G.; Shen, S.; Ding, Y.; Lino, A.C.; Maraver, A.; Lafaille, J. J.; Dustin, M.L. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J. Exp. Med., 2006, 203, 505.
34. Tang, Q.; Adams, J.Y.; Tooley, A.J.; Bi, M.; Fife, B. T.; Serra, P.; Santamaria, P.; Locksley, R.M.; Krummel, M.F.; Bluestone, J.A. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol., 2006, 7, 83.
35. Zhou, L.J.; Tedder, T.F. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol., 1995, 154, 3821.
36. Breloer, M.; Fleischer, B. CD83 regulates lymphocyte maturation, activation and homeostasis. Trends Immunol., 2008, 29, 186.
37. Reinwald, S.; Wiethe, C.; Westendorf, A.M.; Breloer, M.; Probst-Kepper, M.; Fleischer, B.; Steinkasserer, A.; Buer, J.; Hansen, W. CD83 expression in CD4+ T cells modulates inflammation and autoimmunity. J. Immunol., 2008, 180, 5890.
38. Hock, B.D.; Kato, M.; McKenzie, J.L.; Hart, D.N. A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera. Int. Immunol., 2001, 13, 959.
39. Hock, B.D.; O'Donnell, J.L.; Taylor, K.; Steinkasserer, A.; McKenzie, J.L.; Rothwell, A.G.; Summers, K.L. Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients. Tissue Antigens, 2006, 67, 57.
40. Hirano, N.; Butler, M.O.; Xia, Z.; Ansen, S.; von Bergwelt-Baildon, M.S.; Neuberg, D.; Freeman, G.J.; Nadler, L.M. Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity. Blood, 2006, 107, 1528.
41. Lechmann, M.; Krooshoop, D.J.; Dudziak, D.; Kremmer, E.; Kuhnt, C.; Figdor, C.G.; Schuler, G.; Steinkasserer, A. The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells. J. Exp. Med., 2001, 194, 1813.
42. Zinser, E.; Lechmann, M.; Golka, A.; Lutz, M.B.; Steinkasserer, A. Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83. J. Exp. Med., 2004, 200, 345.
43. Scholler, N.; Hayden-Ledbetter, M.; Dahlin, A.; Hellstrom, I.; Hellstrom, K.E.; Ledbetter, J.A. Cutting edge: CD83 regulates the development of cellular immunity. J. Immunol., 2002, 168, 2599.
44. Xu, J.F.; Huang, B.J.; Yin, H.; Xiong, P.; Feng, W.; Xu, Y.; Fang, M.; Zheng, F.; Wang, C.Y.; Gong, F.L. A limited course of soluble CD83 delays acute cellular rejection of MHC-mismatched mouse skin allografts. Transpl. Int., 2007, 20, 266.
45. Senechal, B.; Boruchov, A.M.; Reagan, J.L.; Hart, D.N.; Young, J.W. Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83. Blood, 2004, 103, 4207.
46. Scholler, N.; Hayden-Ledbetter, M.; Hellstrom, K.E.; Hellstrom, I.; Ledbetter, J.A. CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells. J. Immunol., 2001, 166, 3865.
47. Prechtel, A.T.; Turza, N.M.; Theodoridis, A.A.; Steinkasserer, A. CD83 knockdown in monocyte-derived dendritic cells by small interfering RNA leads to a diminished T cell stimulation. J. Immunol., 2007, 178, 5454.
48. Sugimoto, N.; Oida, T.; Hirota, K.; Nakamura, K.; Nomura, T.; Uchiyama, T.; Sakaguchi, S. Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int. Immunol., 2006, 18, 1197.
49. Harrigan, M.T.; Campbell, N.F.; Bourgeois, S. Identification of a gene induced by glucocorticoids in murine T-cells: a potential G protein-coupled receptor. Mol. Endocrinol., 1991, 5, 1331.
50. Parker, R.; Liu, M.; Eyre, H.J.; Copeland, N.G.; Gilbert, D.J.; Crawford, J.; Sutherland, G.R.; Jenkins, N.A.; Herzog, H. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. Biochim. Biophys. Acta, 2000, 1491, 369.
51. Harrigan, M.T.; Baughman, G.; Campbell, N.F.; Bourgeois, S. Isolation and characterization of glucocorticoid- and cyclic AMP-induced genes in T lymphocytes. Mol. Cell Biol., 1989, 9, 3438.
52. Baughman, G.; Harrigan, M.T.; Campbell, N.F.; Nurrish, S.J.; Bourgeois, S. Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol. Endocrinol., 1991, 5, 637.
53. Pesini, P.; Detheux, M.; Parmentier, M.; Hokfelt, T. Distribution of a glucocorticoid-induced orphan receptor (JP05) mRNA in the central nervous system of the mouse. Brain Res. Mol. Brain Res., 1998, 57, 281.
54. Hansen, W.; Loser, K.; Westendorf, A.M.; Bruder, D.; Pfoertner, S.; Siewert, C.; Huehn, J.; Beissert, S.; Buer, J. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. J. Immunol., 2006, 177, 209.
55. Toms, C.; Jessup, H.; Thompson, C.; Baban, D.; Davies, K.; Powrie, F. Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. Immunology, 2008, (epub ahead).
56. Lu, L.F.; Gavin, M.A.; Rasmussen, J.P.; Rudensky, A.Y. G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol. Cell Biol., 2007, 27, 8065.
57. Sah, R.; Parker, S.L.; Sheriff, S.; Eaton, K.; Balasubramaniam, A.; Sallee, F.R. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides, 2007, 28, 302.
58. Sah, R.; Pritchard, L.M.; Richtand, N.M.; Ahlbrand, R.; Eaton, K.; Sallee, F.R.; Herman, J.P. Expression of the glucocorticoid-induced receptor mRNA in rat brain. Neuroscience, 2005, 133, 281.