The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response

Veterinary Immunology and Immunopathology

Volumn 108, Issue 1-2 SPEC. ISS., 2005, Pages 199-209

  Bouhet, Sandrine ^a   Oswald, Isabelle P ^a  

^a CEMAGREF   (France)

Author keywords

Barrier function; Epithelial cells; Food contaminant; Immune system; Intestine; Mycotoxin

Indexed keywords

AFLATOXIN B1; ALTERNARIOL; ANTIMICROBIAL CATIONIC PEPTIDE; CITRININ; CYCLOPIAZONIC ACID; CYTOKINE; ERGOTAMINE; FUMONISIN B1; GLIOTOXIN; IMMUNOGLOBULIN A; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; KOJIC ACID; MONILIFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MYCOPHENOLIC ACID; MYCOTOXIN; OCHRATOXIN; PATULIN; PENICILLIC ACID; TRANSFORMING GROWTH FACTOR ALPHA; TRICHOTHECENE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; ZEARALENONE;

ALTERNARIA; ASPERGILLUS; CELL ACTIVITY; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CLAVICEPS; CONFERENCE PAPER; CYTOKINE RELEASE; FOOD CONTAMINATION; FUNGUS; FUSARIUM; HUMAN; INNATE IMMUNITY; INTESTINE EPITHELIUM CELL; MUCUS SECRETION; NONHUMAN; PENICILLIUM; PEPTIDE SYNTHESIS; PROTEIN FUNCTION; STACHYBOTRYS;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CHEMOKINES; CYTOKINES; EPITHELIAL CELLS; FOOD CONTAMINATION; HUMANS; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; IMMUNOGLOBULIN A, SECRETORY; INTESTINES; MYCOTOXINS;

ANIMALIA;

EID: 24944587966     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2005.08.010     Document Type: Conference Paper

References (73)

1. M. Albassam, S. Yong, R. Bhatnagar, A. Sharma, and M. Prior Histopathologic and electron microscopic studies on the acute toxicity of ochratoxin A in rats Vet. Pathol. 24 1987 427 435
2. J. Azcona-Olivera, J. Ouang, J. Murtha, F. Chu, and J. Pestka Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition Toxicol. Appl. Pharmacol. 133 1995 109 120
3. C.G. Beckett, D. Dell'Olio, R.G. Shidrawi, S. Rosen-Bronson, and P.J. Ciclitira Gluten-induced nitric oxide and pro-inflammatory cytokine release by cultured coeliac small intestinal biopsies Eur. J. Gastroenterol. Hepatol. 11 1999 529 535
4. R.V. Bhat, P.H. Shetty, R.P. Amruth, and R.V. Sudershan A foodborne disease outbreak due to the consumption of moldy sorghum and maize containing fumonisin mycotoxins J. Toxicol. Clin. Toxicol. 35 1997 249 255
5. G.S. Bondy, and J.J. Pestka Immunomodulation by fungal toxins J. Toxicol. Environ. Health B: Crit. Rev. 3 2000 109 143
6. C. Booth, and C.S. Potten Gut instincts: thoughts on intestinal epithelial stem cells J. Clin. Invest. 105 2000 1493 1499
7. 1 alters the proliferation and the barrier function of porcine intestinal epithelial cells Toxicol. Sci. 77 2004 165 171
8. T. Brown, G. Rottinghaus, and M. Williams Fumonisin mycotoxicosis in broilers: performances and pathology Avian Dis. 36 1992 450 454
9. G. Brunsgaard Effects of cereal type and feed particle size on morphological characteristics, epithelial cell proliferation, and lectin binding patterns in the large intestine of pigs J. Anim. Sci. 76 1998 2787 2798
10. CAST, 2003. Mycotoxins: risks in plant, animal, and human systems. Vol Task Force Report 138. Council for Agricultural Science and Technology, Ames, IA, USA, 199 pp.
11. P.J. Chaplin, K.R. Parsons, and R.A. Collins The cloning of cattle interferon-A subtypes isolated from the gut epithelium of rotavirus-infected calves Immunogenetics 44 1996 143 145
12. D.E. Corrier Mycotoxicosis: mechanisms of immunosuppression Vet. Immunol. Immunopathol. 30 1991 73 87
13. J.L. Desseyn, J.P. Aubert, N. Porchet, and A. Laine Evolution of the large secreted gel-forming mucins Mol. Biol. Evol. 17 2000 1175 1184
14. M. Dürr, and A. Peschel Chemokines meet defensins: the merging concepts of chemoattractants and antimicrobial peptides in host defense Infect. Immun. 70 2002 6524 6533
15. A. Dzidic, A. Mohr, K. Meyer, J. Bauer, H.H. Meyer, and M.W. Pfaffl Effects of mycophenolic acid (MPA) treatment on expression of Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIgR) mRNA in adult sheep tissues Croat. Med. J. 45 2004 130 135
16. L. Eckmann, M.F. Kagnoff, and J. Fierer Intestinal epithelial cells as watchdogs for the natural immune system Trends Microbiol. 3 1995 118 120
17. K. Fellermann, and E.F. Stange Defensins - innate immunity at the epithelial frontier Eur. J. Gastroenterol. Hepatol. 13 2001 771 776
18. L. Fitzpatrick, J. Wang, and T. Le In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats Dig. Dis. Sci. 45 2000 2327 2336
19. S.E. Fleming, L.D. Youngman, and B.N. Ames Intestinal cell proliferation is influenced by intakes of protein and energy, aflatoxin, and whole-body radiation Nutr. Cancer 22 1994 11 30
20. K. Fujiwara, M. Ochiai, T. Ohta, M. Ohki, H. Aburatani, M. Nagao, T. Sugimura, and H. Nakagama Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine Carcinogenesis 25 2004 1495 1505
21. C.N. Glover, and C. Hogstrand Effects of dissolved metals and other hydrominerals on in vivo intestinal zinc uptake in freshwater rainbow trout Aquat. Toxicol. 62 2003 281 293
22. B.M. Gumbiner Breaking through the tight junction barrier J. Cell. Biol. 123 1993 1631 1633
23. K. Hashimoto, and M. Shimizu Epithelial properties of human intestinal Caco-2 cells cultured in a serum-free medium Cytotechnology 13 1993 175 184
24. R. Hedman, A. Thuvander, I. Gadhasson, M. Reverter, and H. Petersson Influence of dietary nivalenol exposure on gross pathology and selected immunological parameters in young pigs Nat. Toxins 5 1997 238 246
25. F. Hinoshita, Y. Suzuki, K. Yokoyama, S. Hara, A. Yamada, Y. Ogura, H. Hashimoto, S. Tomura, F. Marumo, and Y. Ueno Experimental IgA nephropathy induced by a low-dose environmental mycotoxin, nivalenol Nephron 75 1997 469 478
26. F. Hoerr, W. Carlton, and B. Yagen Mycotoxicosis caused by a single dose of T-2 toxin or diacetoxyscirpenol in broiler chickens Vet. Pathol. 18 1981 652 664
27. L.V. Hooper, T.S. Stappenbeck, C.V. Hong, and J.I. Gordon Angiogenins: a new class of microbicidal proteins involved in innate immunity Nat. Immunol. 4 2003 269 273
28. M.D. Howard, D.T. Gordon, L.W. Pace, K.A. Garleb, and M.S. Kerley Effects of dietary supplementation with fructooligosaccharides on colonic microbiota populations and epithelial cell proliferation in neonatal pigs J. Pediatr. Gastroenterol. Nutr. 21 1995 297 303
29. G. Hunder, K. Schumann, G. Strugala, J. Gropp, B. Fichtl, and W. Forth Influence of subchronic exposure to low dietary deoxynivalenol, a trichothecene mycotoxin, on intestinal absorption of nutrients in mice Food Chem. Toxicol. 29 1991 809 814
30. R. Jiang, X. Chang, B. Stoll, M.Z. Fan, J. Arthington, E. Weaver, J. Campbell, and D.G. Burrin Dietary plasma protein reduces small intestinal growth and lamina propria cell density in early weaned pigs J. Nutr. 130 2000 21 26
31. H.C. Jung, L. Eckmann, S.K. Yang, A. Panja, J. Fierer, E. Morzycka-Wroblewska, and M.F. Kagnoff A distinct array of pro-inflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion J. Clin. Invest. 95 1995 55 65
32. F. Kasuga, Y. Hara-Kudo, N. Saito, S. Kumagai, and Y. Sugita-Konishi In vitro effect of deoxynivalenol on the differentiation of human colonic cell lines Caco-2 and T84 Mycopathologia 142 1998 161 167
33. D.N. Kitchen, W.W. Carlton, and J. Tuite Ochratoxin A and citrinin induced nephrosis in Beagle dogs. II. Pathology Vet. Pathol. 14 1977 261 272
34. L.F. Kubena, T.D. Phillips, D.A. Witzel, and N.D. Heidelbaugh Toxicity of ochratoxin A and penicillic acid to chicks Bull. Environ. Contam. Toxicol. 32 1984 711 716
35. S.C. Lee, J.T. Beery, and F.S. Chu Immunohistochemical fate of ochratoxin A in mice Toxicol. Appl. Pharmacol. 72 1984 218 227
36. L.W. Leung, R.G. Contreras, C. Flores-Maldonado, M. Cereijido, and E. Rodriguez-Boulan Inhibitors of glycosphingolipid biosynthesis reduce transepithelial electrical resistance in MDCK I and FRT cells Am. J. Physiol. Cell. Physiol. 284 2003 C1021 C1030
37. S.A. Lewis, J.R. Berg, and T.J. Kleine Modulation of epithelial permeability by extracellular macromolecules Physiol. Rev. 75 1995 561 589
38. G. Li, J. Shinozuka, K. Uetsuka, H. Nakayama, and K. Doi T-2 toxin-induced apoptosis in intestinal crypt epithelial cells of mice Exp. Toxicol. Pathol. 49 1997 447 450
39. R. Mahfoud, M. Maresca, N. Garmy, and J. Fantini The mycotoxin patulin alters the barrier function of the intestinal epithelium: mechanism of action of the toxin and protective effects of glutathione Toxicol. Appl. Pharmacol. 181 2002 209 218
40. M. Maresca, R. Mahfoud, A. Pfohl-Leszkowicz, and J. Fantini The mycotoxin ochratoxin A alters intestinal barrier and absorption functions but has no effect on chloride secretion Toxicol. Appl. Pharmacol. 176 2001 54 63
41. M. Maresca, R. Mahfoud, N. Garmy, and J. Fantini The mycotoxin deoxynivalenol affects nutrient absorption in human intestinal epithelial cells J. Nutr. 132 2002 2723 2731
42. D.W. McGee, S.J. Vitkus, and P. Lee The effect of cytokine stimulation on IL-1 receptor mRNA expression by intestinal epithelial cells Cell. Immunol. 168 1996 276 280
43. E.R. McKinley, W.W. Carlton, and G.D. Boon Patulin mycotoxicosis in the rat: toxicology, pathology and clinical pathology Food. Chem. Toxicol. 20 1982 289 300
44. J. McLaughlin, P.J. Padfield, J.P. Burt, and C.A. O'Neill Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms Am. J. Physiol. Cell. Physiol. 287 2004 1412 1417
45. L. Montagne, C. Piel, and J.P. Lalles Effect of diet on mucin kinetics and composition: nutrition and health implications Nutr. Rev. 62 2004 105 114
46. Y. Muneta, N. Goji, N.M. Tsuji, O. Mikami, Y. Shimoji, Y. Nakajima, Y. Yokomizo, and Y. Mori Expression of interleukin-18 by porcine airway and intestinal epithelium J. Interferon Cytokine Res. 22 2002 883 889
47. T. Nagata, H. Suzuki, N. Ishigami, J. Shinozuka, K. Uetsuka, H. Nakayama, and K. Doi Development of apoptosis and changes in lymphocytes subsets in thymus, mesenteric lymph nodes and Peyer's patches of mice orally inoculated with T-2 toxin Exp. Toxicol. Pathol. 53 2001 309 315
48. K. Ogushi, A. Wada, T. Niidome, N. Mori, K. Oishi, T. Nagatake, A. Takahashi, H. Asakura, S. Makino, H. Hojo, Y. Nakahara, M. Ohsaki, T. Hatakeyama, H. Aoyagi, H. Kurazono, J. Moss, and T. Hirayama Salmonella enteritidis FliC (flagella filament protein) induces human beta-defensin-2 mRNA production by Caco-2 cells J. Biol. Chem. 276 2001 30521 30526
49. I.P. Oswald, and C. Coméra Immunotoxicity of mycotoxins Rev. Med. Vet. 149 1998 585 590
50. 1 increases intestinal colonization by pathogenic Escherichia coli in pigs Appl. Environ. Microbiol. 69 2003 5870 5874
51. 1 inhibits integrin-mediated cell-matrix adhesion Biochimie 81 1999 1003 1008
52. J. Perez-Vilar, and R.L. Hill The structure and assembly of secreted mucins J. Biol. Chem. 274 1999 31751 31754
53. J.J. Pestka Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions Toxicol. Lett 140-141 2003 287 295
54. S. Pié, J.P. Lalles, F. Blazy, J. Laffitte, B. Seve, and I.P. Oswald Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets J. Nutr. 134 2004 641 647
55. P. Pinton, E. Royer, F. Accensi, D. Marin, J. Guelfi, N. Bourgès-Abella, R. Granier, F. Grosjean, and I.P. Oswald Effets zootechniques et immunitaires de la consommation d'aliment naturellement contaminé par du déoxynivalénol (DON) chez le porc en phase de croissance ou de finition J. Rech. Porcine 36 2004 301 308 (in French with English abstract)
56. R.S. Pitman, and R.S. Blumberg First line of defense: the role of the intestinal epithelium as an active component of the mucosal immune system J. Gastroenterol. 35 2000 805 814
57. 1 in food-producing animals Adv. Exp. Med. Biol. 392 1996 265 278
58. L. Rasooly, and J.J. Pestka Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens Food Chem. Toxicol. 30 1992 499 504
59. K.V. Sastry, and P.V. Malik Studies on the effect of dimecron on the digestive system of a fresh water fish, Channa punctatus Arch. Environ. Contam. Toxicol. 8 1979 397 407
60. 1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases Toxicol. Appl. Pharmacol. 148 1998 252 260
61. L. Shao, D. Serrano, and L. Mayer The role of epithelial cells in immune regulation in the gut Semin. Immunol. 13 2001 163 176
62. 1 in vervet monkeys Nat. Toxins 3 1995 145 150
63. A.W. Stadnyk Intestinal epithelial cells as a source of inflammatory cytokines and chemokines Can. J. Gastroenterol. 16 2002 241 246
64. H.V. Swamy, T.K. Smith, E.J. MacDonald, H.J. Boermans, and E.J. Squires Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent J. Anim. Sci. 80 2002 3257 3267
65. G.M. Szczech, W.W. Carlton, J. Tuite, and R. Caldwell Ochratoxin A toxicosis in swine Vet. Pathol. 10 1973 347 364
66. A.P. Tarver, D.P. Clark, G. Diamond, J.P. Russell, H. Erdjument-Bromage, P. Tempst, K.S. Cohen, D.E. Jones, R.W. Sweeney, M. Wines, S. Hwang, and C.L. Bevins Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection Infect. Immun. 66 1998 1045 1056
67. 1 in experimental subchronic mycotoxicoses in rats Clin. Diagn. Lab. Immunol. 9 2002 149 155
68. H. Watanabe, A. Narai, and M. Shimizu Purification and cDNA cloning of a protein derived from Flammulina velutipes that increases the permeability of the intestinal Caco-2 cell monolayer Eur. J. Biochem. 262 1999 850 857
69. G.A. Weaver, H.J. Kurtz, F.Y. Bates, C.J. Mirocha, J.C. Behrens, and W.M. Hagler Diacetoxyscirpenol toxicity in pigs Res. Vet. Sci. 31 1981 131 135
70. 1 (Environmental Health Criteria 219), Geneva, Switzerland, 153 pp.
71. P.P. Williams Effects of T-2 mycotoxin on gastrointestinal tissues: a review of in vivo and in vitro models Arch. Environ. Contam. Toxicol. 18 1989 374 387
72. D. Yang, A. Biragyn, L. Kwak, and J. Oppenheim Mammalian defensins in immunity: more than just microbicidal Trends. Immunol. 23 2002 291 296
73. M. Zanetti Cathelicidins, multifunctional peptides of the innate immunity J. Leukoc. Biol. 75 2004 39 48