Aging affects epidermal Langerhans cell development and function and alters their miRNA gene expression profile

Aging

Volumn 4, Issue 11, 2012, Pages 742-754

  Xu, Ying Ping ^a,b   Qi, Rui Qun ^a,c   Chen, Wen Bin ^a   Shi, Yu Ling ^a   Cui, Zhi Zhong ^b   Gao, Xing Hua ^c   Chen, Hong Duo ^c   Zhou, Li ^a   Mi, Qing Sheng ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b SHANDONG AGRICULTURAL UNIVERSITY   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Aging; Dendritic cells; Langerhans cells; miRNAs; Skin

Indexed keywords

EID: 84872508592     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100501     Document Type: Article

References (61)

1. Sauder DN. Effect of age on epidermal immune function. Dermatol Clin. 1986; 4:447-454.
2. Huang MC, Liao JJ, Bonasera S, Longo DL and Goetzl EJ. Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 2008; 22:2142-2150.
3. Fortin CF, Lesur O and Fulop T, Jr. Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions. FEBS Lett. 2007; 581:1173-1178.
4. Mocchegiani E and Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell. 2004; 3:177-184.
5. Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J and Sambhara S. Innate immunity in aging: impact on macrophage function. Aging Cell. 2004; 3:161-167.
6. Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S and Goldstein DR. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell. 2006; 5:473-486.
7. Agrawal A, Agrawal S, Cao JN, Su H, Osann K and Gupta S. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol. 2007; 178:6912-6922.
8. Shodell M and Siegal FP. Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing. Scand J Immunol. 2002; 56:518-521.
9. Zhao J, Legge K and Perlman S. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection inmice. J Clin Invest. 121:4921-4930.
10. Bhushan M, Cumberbatch M, Dearman RJ, Kimber I and Griffiths CE. Exogenous interleukin-1beta restores impaired Langerhans cell migration in aged skin. Br J Dermatol. 2004; 150:1217-1218.
11. Kim VN, Han J and Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009; 10:126-139.
12. Zhou L, Seo KH, He HZ, Pacholczyk R, Meng DM, Li CG, Xu J, She JX, Dong Z and Mi QS. Tie2cre-induced inactivation of the miRNA-processing enzyme Dicer disrupts invariant NKT cell development. Proc Natl Acad Sci U S A. 2009; 106:10266-10271.
13. Cobb BS, Hertweck A, Smith J, O'Connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG and Merkenschlager M. A role for Dicer in immune regulation. J Exp Med. 2006; 203:2519-2527.
14. Liston A, Lu LF, O'Carroll D, Tarakhovsky A and Rudensky AY. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 2008; 205:1993-2004.
15. Kuipers H, Schnorfeil FM, Fehling HJ, Bartels H and Brocker T. Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo. J Immunol. 185:400-409.
16. Dooley J and Liston A. Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue. Eur J Immunol. 42:1073-1079.
17. Jiang M, Xiang Y, Wang D, Gao J, Liu D, Liu Y, Liu S and Zheng D. Dysregulated expression of miR-146a contributes to agerelated dysfunction of macrophages. Aging Cell. 11:29-40.
18. Martinez I, Almstead LL and DiMaio D. MicroRNAs and senescence. Aging (Albany NY). 3:77-78.
19. Lee J and Kemper JK. Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging (Albany NY). 2:527-534.
20. Marasa BS, Srikantan S, Martindale JL, Kim MM, Lee EK, Gorospe M and Abdelmohsen K. MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany NY). 2:333-343.
21. Sprecher E, Becker Y, Kraal G, Hall E, Harrison D and Shultz LD. Effect of aging on epidermal dendritic cell populations in C57BL/6J mice. J Invest Dermatol. 1990; 94:247-253.
22. + T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells. Mech Ageing Dev. 132:187-194.
23. + T-cell immunity by immature dendritic cells in a vaccination setting. Blood. 2009; 113:5167-5175.
24. Romani N, Clausen BE and Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev. 234:120-141.
25. Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5:2087-2102.
26. Gems D and Guardia YD. Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction? Antioxid Redox Signal.
27. Valladeau J, Dezutter-Dambuyant C and Saeland S. Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells. Immunol Res. 2003; 28:93-107.
28. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances V, Vincent C, Schmitt D, Davoust J, Caux C, Lebecque S and Saeland S. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000; 12:71-81.
29. Nagao K, Ginhoux F, Leitner WW, Motegi S, Bennett CL, Clausen BE, Merad M and Udey MC. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A. 2009; 106:3312-3317.
30. Ortner U, Inaba K, Koch F, Heine M, Miwa M, Schuler G and Romani N. An improved isolation method for murine migratory cutaneous dendritic cells. J Immunol Methods. 1996; 193:71-79.
31. Xu D and Tahara H. The role of exosomes and microRNAs in senescence and aging. Adv Drug Deliv Rev.
32. Qi R, Weiland M, Gao XH, Zhou L and Mi QS. Identification of endogenous normalizers for serum microRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer. Hepatology. 55(5):1640-1642; author reply 1642-1643.
33. Rathinam C, Geffers R, Yucel R, Buer J, Welte K, Moroy T and Klein C. The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function. Immunity. 2005; 22:717-728.
34. Schiavoni G, Mattei F, Borghi P, Sestili P, Venditti M, Morse HC, 3rd, Belardelli F and Gabriele L. ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells. Blood. 2004; 103:2221-2228.
35. Fainaru O, Woolf E, Lotem J, Yarmus M, Brenner O, Goldenberg D, Negreanu V, Bernstein Y, Levanon D, Jung S and Groner Y. Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J. 2004; 23:969-979.
36. Iwama A, Osawa M, Hirasawa R, Uchiyama N, Kaneko S, Onodera M, Shibuya K, Shibuya A, Vinson C, Tenen DG and Nakauchi H. Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med. 2002; 195:547-558.
37. Kel JM, Girard-Madoux MJ, Reizis B and Clausen BE. TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis. J Immunol. 185:3248-3255.
38. Jux B, Kadow S and Esser C. Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice. J Immunol. 2009; 182:6709-6717.
39. Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM and Beissert S. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med. 2006; 12:1372-1379.
40. Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ and Merad M. Langerhans cells arise from monocytes in vivo. Nat Immunol. 2006; 7:265-273.
41. Gruver AL, Hudson LL and Sempowski GD. Immunosenescence of ageing. J Pathol. 2007; 211:144-156.
42. Merad M, Ginhoux F and Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol. 2008; 8:935-947.
43. Witmer-Pack MD, Olivier W, Valinsky J, Schuler G and Steinman RM. Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med. 1987; 166:1484-1498.
44. Bhushan M, Cumberbatch M, Dearman RJ, Andrew SM, Kimber I and Griffiths CE. Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing. Br J Dermatol. 2002; 146:32-40.
45. Ogden S, Dearman RJ, Kimber I and Griffiths CE. The effect of ageing on phenotype and function of monocyte-derived Langerhans cells. Br J Dermatol. 165:184-188.
46. Grolleau-Julius A, Harning EK, Abernathy LM and Yung RL. Impaired dendritic cell function in aging leads to defective antitumor immunity. Cancer Res. 2008; 68:6341-6349.
47. Paula C, Motta A, Schmitz C, Nunes CP, Souza AP and Bonorino C. Alterations in dendritic cell function in aged mice: potential implications for immunotherapy design. Biogerontology. 2009; 10:13-25.
48. Moretto MM, Lawlor EM and Khan IA. Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen. J Immunol. 2008; 181:7977-7984.
49. Appay V, Sauce D and Prelog M. The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals. Aging (Albany NY). 2:78-81.
50. Zheng Q, Zhou L and Mi QS. MicroRNA miR-150 is involved in Valpha14 invariant NKT cell development and function. J Immunol. 188:2118-2126.
51. Mehr R and Melamed D. Reversing B cell aging. Aging (Albany NY). 3:438-443.
52. O'Connell RM, Rao DS, Chaudhuri AA and Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol. 10:111-122.
53. Provost P. Interpretation and applicability of microRNA data to the context of Alzheimer's and age-related diseases. Aging (Albany NY). 2:166-169.
54. Li X, Khanna A, Li N and Wang E. Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY). 3:985-1002.
55. Li X, Khanna A, Li N and Wang E. Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY). 3:985-1002.
56. Mi QS, Xu YP, Wang H, Qi RQ, Dong Z and Zhou L. Deletion of microRNA miR-223 increases Langerhans cell cross-presentation. Int J Biochem Cell Biol.2012; PMID:23153510.
57. Borkowski TA, Letterio JJ, Farr AG and Udey MC. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med. 1996; 184:2417-2422.
58. Heinz LX, Platzer B, Reisner PM, Jorgl A, Taschner S, Gobel F and Strobl H. Differential involvement of PU.1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment. Blood. 2006; 107:1445-1453.
59. Hacker C, Kirsch RD, Ju XS, Hieronymus T, Gust TC, Kuhl C, Jorgas T, Kurz SM, Rose-John S, Yokota Y and Zenke M. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol. 2003; 4:380-386.
60. Barbaroux JB, Beleut M, Brisken C, Mueller CG and Groves RW. Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation. J Immunol. 2008; 181:1103-1108.
61. Kissenpfennig A, Ait-Yahia S, Clair-Moninot V, Stossel H, Badell E, Bordat Y, Pooley JL, Lang T, Prina E, Coste I, Gresser O, Renno T, Winter N, et al. Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function. Mol Cell Biol. 2005; 25:88-99.