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Volumn 42, Issue 5, 2012, Pages 1073-1079

Molecular control over thymic involution: From cytokines and microRNA to aging and adipose tissue

Author keywords

Aging; Animal models; Epithelial cells; Lymphoid organs; T cells

Indexed keywords

CYTOKINE; MICRORNA; SEX HORMONE;

EID: 84860351016     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142305     Document Type: Review
Times cited : (126)

References (68)
  • 1
    • 0025810875 scopus 로고
    • Hypothesis: involution of the thymus with aging-programmed and beneficial
    • Aronson, M., Hypothesis: involution of the thymus with aging-programmed and beneficial. Thymus 1991. 18: 7-13.
    • (1991) Thymus , vol.18 , pp. 7-13
    • Aronson, M.1
  • 2
    • 67649393344 scopus 로고    scopus 로고
    • Why does the thymus involute? A selection-based hypothesis
    • Dowling, M. R.andHodgkin, P. D., Why does the thymus involute? A selection-based hypothesis. Trends Immunol. 2009. 30: 295-300.
    • (2009) Trends Immunol. , vol.30 , pp. 295-300
    • Dowling, M.R.1    Hodgkin, P.D.2
  • 3
    • 67649410701 scopus 로고    scopus 로고
    • An evolutionary perspective on the mechanisms of immunosenescence
    • Shanley, D. P., Aw, D., Manley, N. R.andPalmer, D. B., An evolutionary perspective on the mechanisms of immunosenescence. Trends Immunol. 2009. 30: 374-381.
    • (2009) Trends Immunol. , vol.30 , pp. 374-381
    • Shanley, D.P.1    Aw, D.2    Manley, N.R.3    Palmer, D.B.4
  • 4
    • 79952779696 scopus 로고    scopus 로고
    • Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses
    • Billard, M. J., Gruver, A. L.andSempowski, G. D., Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses. PLoS ONE 1999. 6: e17940.
    • (1999) PLoS ONE , vol.6
    • Billard, M.J.1    Gruver, A.L.2    Sempowski, G.D.3
  • 8
    • 0037624646 scopus 로고    scopus 로고
    • The grade of acute thymus involution in neonates correlates with the duration of acute illness and with the percentage of lymphocytes in peripheral blood smear. Pathological study
    • Glavina-Durdov, M., Springer, O., Capkun, V., Saratlija-Novakovic, Z., Rozic, D.andBarle, M., The grade of acute thymus involution in neonates correlates with the duration of acute illness and with the percentage of lymphocytes in peripheral blood smear. Pathological study. Biol. Neonate 2003. 83: 229-234.
    • (2003) Biol. Neonate , vol.83 , pp. 229-234
    • Glavina-Durdov, M.1    Springer, O.2    Capkun, V.3    Saratlija-Novakovic, Z.4    Rozic, D.5    Barle, M.6
  • 10
    • 0029097083 scopus 로고
    • Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice
    • Godfraind, C., Holmes, K. V.and.Coutelier, J. P., Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice. J. Virol. 1995. 69: 6541-6547.
    • (1995) J. Virol. , vol.69 , pp. 6541-6547
    • Godfraind, C.1    Holmes, K.V.2    Coutelier, J.P.3
  • 12
    • 77952336147 scopus 로고    scopus 로고
    • Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus
    • Anz, D., Thaler, R., Stephan, N., Waibler, Z., Trauscheid, M. J., Scholz, C., Kalinke, U.et al., Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J. Immunol. 2009. 182: 6044-6050.
    • (2009) J. Immunol. , vol.182 , pp. 6044-6050
    • Anz, D.1    Thaler, R.2    Stephan, N.3    Waibler, Z.4    Trauscheid, M.J.5    Scholz, C.6    Kalinke, U.7
  • 14
    • 58149184316 scopus 로고    scopus 로고
    • Reversible blockade of thymic output: an inherent part of TLR ligand-mediated immune response
    • Demoulins, T., Abdallah, A., Kettaf, N., Baron, M. L., Gerarduzzi, C., Gauchat, D., Gratton, S.et al., Reversible blockade of thymic output: an inherent part of TLR ligand-mediated immune response. J. Immunol. 2008. 181: 6757-6769.
    • (2008) J. Immunol. , vol.181 , pp. 6757-6769
    • Demoulins, T.1    Abdallah, A.2    Kettaf, N.3    Baron, M.L.4    Gerarduzzi, C.5    Gauchat, D.6    Gratton, S.7
  • 15
    • 84855931651 scopus 로고    scopus 로고
    • The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via suppression of the IFN-α receptor mediated by microRNA-29 a
    • Papadopoulou, A. S., Dooley, J., Linterman, M. A., Pierson, W., Ucar, O., Kyewski, B., Zuklys, S.et al., The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via suppression of the IFN-α receptor mediated by microRNA-29 a. Nat. Immunol. 2012. 13: 181-187.
    • (2012) Nat. Immunol. , vol.13 , pp. 181-187
    • Papadopoulou, A.S.1    Dooley, J.2    Linterman, M.A.3    Pierson, W.4    Ucar, O.5    Kyewski, B.6    Zuklys, S.7
  • 16
    • 0036467492 scopus 로고    scopus 로고
    • The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
    • Taniguchi, T. and Takaoka, A., The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr. Opin. Immunol. 2002. 14: 111-116.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 111-116
    • Taniguchi, T.1    Takaoka, A.2
  • 17
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells
    • 108: 3777--3785.
    • Gray, D. H., Seach, N., Ueno, T., Milton, M. K., Liston, A., Lew, A. M., Goodnow, C. C.et al., Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells. Blood 2006. 108: 3777--3785.
    • (2006) Blood
    • Gray, D.H.1    Seach, N.2    Ueno, T.3    Milton, M.K.4    Liston, A.5    Lew, A.M.6    Goodnow, C.C.7
  • 18
    • 0022351986 scopus 로고
    • Age-related changes in the thymus-dependent immune system
    • Steinmann, G. G.andMuller-Hermelink, H. K., Age-related changes in the thymus-dependent immune system. Dtsch. Med. Wochenschr. 1985. 110: 1300-1307.
    • (1985) Dtsch. Med. Wochenschr. , vol.110 , pp. 1300-1307
    • Steinmann, G.G.1    Muller-Hermelink, H.K.2
  • 19
    • 82155201761 scopus 로고    scopus 로고
    • Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells
    • Zook, E. C., Krishack, P. A., Zhang, S., Zeleznik-Le, N. J., Firulli, A. B., Witte, P. L.andLe, P. T., Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells. Blood 2011. 118: 5723--5731.
    • (2011) Blood , vol.118 , pp. 5723-5731
    • Zook, E.C.1    Krishack, P.A.2    Zhang, S.3    Zeleznik-Le, N.J.4    Firulli, A.B.5    Witte, P.L.6    Le, P.T.7
  • 20
    • 0035098105 scopus 로고    scopus 로고
    • Androgen receptors in thymic epithelium modulate thymus size and thymocyte development
    • Olsen, N. J., Olson, G., Viselli, S. M., Gu, X.andKovacs, W. J., Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 2001. 142: 1278-1283.
    • (2001) Endocrinology , vol.142 , pp. 1278-1283
    • Olsen, N.J.1    Olson, G.2    Viselli, S.M.3    Gu, X.4    Kovacs, W.J.5
  • 22
    • 0032826488 scopus 로고    scopus 로고
    • Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations
    • Staples, J. E., Gasiewicz, T. A., Fiore, N. C., Lubahn, D. B., Korach, K. S.andSilverstone, A. E., Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations. J. Immunol. 1999. 163: 4168-4174.
    • (1999) J. Immunol. , vol.163 , pp. 4168-4174
    • Staples, J.E.1    Gasiewicz, T.A.2    Fiore, N.C.3    Lubahn, D.B.4    Korach, K.S.5    Silverstone, A.E.6
  • 23
    • 0038381818 scopus 로고    scopus 로고
    • Hormones and the aging process
    • Morley, J. E., Hormones and the aging process. J. Am. Geriatr. Soc. 2003. 51: S333-337.
    • (2003) J. Am. Geriatr. Soc. , vol.51
    • Morley, J.E.1
  • 24
    • 29444460806 scopus 로고    scopus 로고
    • Reassessing the role of growth hormone and sex steroids in thymic involution
    • Min, H., Montecino-Rodriguez, E.andDorshkind, K., Reassessing the role of growth hormone and sex steroids in thymic involution. Clin. Immunol. 2006. 118: 117-123.
    • (2006) Clin. Immunol. , vol.118 , pp. 117-123
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 25
    • 70349231092 scopus 로고    scopus 로고
    • Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution
    • Yang, H., Youm, Y. H.andDixit, V. D., Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J. Immunol. 2009. 183: 3040-3052.
    • (2009) J. Immunol. , vol.183 , pp. 3040-3052
    • Yang, H.1    Youm, Y.H.2    Dixit, V.D.3
  • 26
    • 0032741972 scopus 로고    scopus 로고
    • Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
    • Howard, J. K., Lord, G. M., Matarese, G., Vendetti, S., Ghatei, M. A., Ritter, M. A., Lechler, R. I.et al., Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 1999. 104: 1051-1059.
    • (1999) J. Clin. Invest. , vol.104 , pp. 1051-1059
    • Howard, J.K.1    Lord, G.M.2    Matarese, G.3    Vendetti, S.4    Ghatei, M.A.5    Ritter, M.A.6    Lechler, R.I.7
  • 27
    • 70349766380 scopus 로고    scopus 로고
    • Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution
    • Gruver, A. L., Ventevogel, M. S.andSempowski, G. D., Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution. J. Endocrinol. 2009. 203: 75-85.
    • (2009) J. Endocrinol. , vol.203 , pp. 75-85
    • Gruver, A.L.1    Ventevogel, M.S.2    Sempowski, G.D.3
  • 28
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation, and hematopoiesis
    • Fantuzzi, G.andFaggioni, R., Leptin in the regulation of immunity, inflammation, and hematopoiesis. J. Leukoc. Biol. 2000. 68: 437-446.
    • (2000) J. Leukoc. Biol. , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 29
    • 0028889619 scopus 로고
    • Interactions between adipose tissue around lymph nodes and lymphoid cells in vitro
    • Pond, C. M.andMattacks, C. A., Interactions between adipose tissue around lymph nodes and lymphoid cells in vitro. J. Lipid Res. 1995. 36: 2219-2231.
    • (1995) J. Lipid Res. , vol.36 , pp. 2219-2231
    • Pond, C.M.1    Mattacks, C.A.2
  • 31
    • 0042662851 scopus 로고    scopus 로고
    • Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors
    • Jenkinson, W. E., Jenkinson, E. J.andAnderson, G., Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors. J. Exp. Med. 2003. 198: 325-332.
    • (2003) J. Exp. Med. , vol.198 , pp. 325-332
    • Jenkinson, W.E.1    Jenkinson, E.J.2    Anderson, G.3
  • 32
    • 33846867492 scopus 로고    scopus 로고
    • PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches
    • Jenkinson, W. E., Rossi, S. W., Parnell, S. M., Jenkinson, E. J. and Anderson, G., PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches. Blood 2007. 109: 954-960.
    • (2007) Blood , vol.109 , pp. 954-960
    • Jenkinson, W.E.1    Rossi, S.W.2    Parnell, S.M.3    Jenkinson, E.J.4    Anderson, G.5
  • 33
    • 37249089365 scopus 로고    scopus 로고
    • FGFR2IIIb signaling regulates thymic epithelial differentiation
    • Dooley, J., Erickson, M., Larochelle, W. J., Gillard, G. O.andFarr, A. G., FGFR2IIIb signaling regulates thymic epithelial differentiation. Dev. Dyn. 2007. 236: 3459-3471.
    • (2007) Dev. Dyn. , vol.236 , pp. 3459-3471
    • Dooley, J.1    Erickson, M.2    Larochelle, W.J.3    Gillard, G.O.4    Farr, A.G.5
  • 34
    • 0035881543 scopus 로고    scopus 로고
    • Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb
    • Revest, J. M., Suniara, R. K., Kerr, K., Owen, J. J.andDickson, C., Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J. Immunol. 2001. 167: 1954-1961.
    • (2001) J. Immunol. , vol.167 , pp. 1954-1961
    • Revest, J.M.1    Suniara, R.K.2    Kerr, K.3    Owen, J.J.4    Dickson, C.5
  • 35
  • 36
    • 0025855769 scopus 로고
    • Studies on the thymus in nonobese diabetic mouse. I. Changes in the microenvironmental compartments
    • Savino, W., Boitard, C., Bach, J. F.andDardenne, M., Studies on the thymus in nonobese diabetic mouse. I. Changes in the microenvironmental compartments. Lab. Invest. 1991. 64: 405-417.
    • (1991) Lab. Invest. , vol.64 , pp. 405-417
    • Savino, W.1    Boitard, C.2    Bach, J.F.3    Dardenne, M.4
  • 37
    • 0034651657 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
    • Sempowski, G. D., Hale, L. P., Sundy, J. S., Massey, J. M., Koup, R. A., Douek, D. C., Patel, D. D.et al., Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J. Immunol. 2000. 164: 2180-2187.
    • (2000) J. Immunol. , vol.164 , pp. 2180-2187
    • Sempowski, G.D.1    Hale, L.P.2    Sundy, J.S.3    Massey, J.M.4    Koup, R.A.5    Douek, D.C.6    Patel, D.D.7
  • 38
    • 34250896228 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is induced by the inflammatory cytokines interleukin-6 and oncostatin m in human adipose tissue in vitro and in murine adipose tissue in vivo
    • Rega, G., Kaun, C., Demyanets, S., Pfaffenberger, S., Rychli, K., Hohensinner, P. J., Kastl, S. P.et al., Vascular endothelial growth factor is induced by the inflammatory cytokines interleukin-6 and oncostatin m in human adipose tissue in vitro and in murine adipose tissue in vivo. Arterioscler. Thromb. Vasc. Biol. 2007. 27: 1587-1595.
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 1587-1595
    • Rega, G.1    Kaun, C.2    Demyanets, S.3    Pfaffenberger, S.4    Rychli, K.5    Hohensinner, P.J.6    Kastl, S.P.7
  • 40
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn, P.andWood, I. S., Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br. J. Nutr. 2004. 92: 347-355.
    • (2004) Br. J. Nutr. , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 41
    • 0029553888 scopus 로고
    • Evaluation of the efficacy of naltrexone in alcoholism by the determination of serum carbohydrate-deficient transferrin
    • Martinez Ruiz, M., Llobell Segui, G., Peralba Vano, J. L.andToral Revuelta, J. R., Evaluation of the efficacy of naltrexone in alcoholism by the determination of serum carbohydrate-deficient transferrin. Ann. Med. Int. 1995. 12: 589-592.
    • (1995) Ann. Med. Int. , vol.12 , pp. 589-592
    • Martinez Ruiz, M.1    Llobell Segui, G.2    Peralba Vano, J.L.3    Toral Revuelta, J.R.4
  • 42
    • 0141891205 scopus 로고    scopus 로고
    • Characterization of vascular adhesion molecules that may facilitate progenitor homing in the post-natal mouse thymus
    • Lepique, A. P., Palencia, S., Irjala, H.andPetrie, H. T., Characterization of vascular adhesion molecules that may facilitate progenitor homing in the post-natal mouse thymus. Clin. Dev. Immunol. 2003. 10: 27-33.
    • (2003) Clin. Dev. Immunol. , vol.10 , pp. 27-33
    • Lepique, A.P.1    Palencia, S.2    Irjala, H.3    Petrie, H.T.4
  • 43
    • 65549089187 scopus 로고    scopus 로고
    • Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25
    • Gossens, K., Naus, S., Corbel, S. Y., Lin, S., Rossi, F. M., Kast, J.andZiltener, H. J., Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J. Exp. Med. 2009. 206: 761-778.
    • (2009) J. Exp. Med. , vol.206 , pp. 761-778
    • Gossens, K.1    Naus, S.2    Corbel, S.Y.3    Lin, S.4    Rossi, F.M.5    Kast, J.6    Ziltener, H.J.7
  • 44
    • 0023250868 scopus 로고
    • Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled
    • Kyewski, B. A., Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled. J. Exp. Med. 1987. 166: 520-538.
    • (1987) J. Exp. Med. , vol.166 , pp. 520-538
    • Kyewski, B.A.1
  • 45
    • 0035898387 scopus 로고    scopus 로고
    • Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development
    • Lind, E. F., Prockop, S. E., Porritt, H. E.andPetrie, H. T., Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med. 2001. 194: 127-134.
    • (2001) J. Exp. Med. , vol.194 , pp. 127-134
    • Lind, E.F.1    Prockop, S.E.2    Porritt, H.E.3    Petrie, H.T.4
  • 46
    • 34447570906 scopus 로고    scopus 로고
    • The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma
    • Mori, K., Itoi, M., Tsukamoto, N., Kubo, H.andAmagai, T., The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma. Int. Immunol. 2007. 19: 745-753.
    • (2007) Int. Immunol. , vol.19 , pp. 745-753
    • Mori, K.1    Itoi, M.2    Tsukamoto, N.3    Kubo, H.4    Amagai, T.5
  • 47
    • 0030746602 scopus 로고    scopus 로고
    • Thymic microvascular system
    • Kato, S., Thymic microvascular system. Microsc. Res. Tech. 1997. 38: 287-299.
    • (1997) Microsc. Res. Tech. , vol.38 , pp. 287-299
    • Kato, S.1
  • 48
    • 49749135227 scopus 로고    scopus 로고
    • Age-related changes in the human thymus studied with scanning electron microscopy
    • Cavallotti, C., D'Andrea, V., Tonnarini, G.andBruzzone, P., Age-related changes in the human thymus studied with scanning electron microscopy. Microsc. Res. Tech. 2008. 71: 573-578.
    • (2008) Microsc. Res. Tech. , vol.71 , pp. 573-578
    • Cavallotti, C.1    D'Andrea, V.2    Tonnarini, G.3    Bruzzone, P.4
  • 49
    • 0033647071 scopus 로고    scopus 로고
    • The thymus in the mouse changes its activity during pregnancy: a study of the microenvironment
    • Kendall, M. D.andClarke, A. G., The thymus in the mouse changes its activity during pregnancy: a study of the microenvironment. J. Anat. 2000. 197(Pt 3): 393-411.
    • (2000) J. Anat. , vol.197 , Issue.PART 3 , pp. 393-411
    • Kendall, M.D.1    Clarke, A.G.2
  • 50
    • 0032738430 scopus 로고    scopus 로고
    • Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility
    • 1.
    • Tibbetts, T. A., DeMayo, F., Rich, S., Conneely, O. M.andO'Malley, B. W., Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. Proc. Natl. Acad. Sci. USA 1999. 96: 12021-12026.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2021-12026
    • Tibbetts, T.A.1    DeMayo, F.2    Rich, S.3    Conneely, O.M.4    O'Malley, B.W.5
  • 52
    • 34247514278 scopus 로고    scopus 로고
    • Murine pregnancy leads to reduced proliferation of maternal thymocytes and decreased thymic emigration
    • Zoller, A. L., Schnell, F. J.andKersh, G. J., Murine pregnancy leads to reduced proliferation of maternal thymocytes and decreased thymic emigration. Immunology 2007. 121: 207-215.
    • (2007) Immunology , vol.121 , pp. 207-215
    • Zoller, A.L.1    Schnell, F.J.2    Kersh, G.J.3
  • 53
    • 0037388551 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin
    • Dixit, V. D., Sridaran, R., Edmonsond, M. A., Taub, D.andThompson, W. E., Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin. Endocrinology 2003. 144: 1496-1505.
    • (2003) Endocrinology , vol.144 , pp. 1496-1505
    • Dixit, V.D.1    Sridaran, R.2    Edmonsond, M.A.3    Taub, D.4    Thompson, W.E.5
  • 54
    • 0027331409 scopus 로고
    • Suppression of B lymphopoiesis during normal pregnancy
    • Medina, K. L., Smithson, G.andKincade, P. W., Suppression of B lymphopoiesis during normal pregnancy. J. Exp. Med. 1993. 178: 1507-1515.
    • (1993) J. Exp. Med. , vol.178 , pp. 1507-1515
    • Medina, K.L.1    Smithson, G.2    Kincade, P.W.3
  • 55
    • 0028276002 scopus 로고
    • Pregnancy-related steroids are potential negative regulators of B lymphopoiesis
    • Medina, K. L.andKincade, P. W., Pregnancy-related steroids are potential negative regulators of B lymphopoiesis. Proc. Natl. Acad. Sci. USA 1994. 91: 5382-5386.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5382-5386
    • Medina, K.L.1    Kincade, P.W.2
  • 56
    • 0033392203 scopus 로고    scopus 로고
    • In vitro apoptosis of lymphocytes after exposure to levels of corticosterone observed following submaximal exercise
    • Hoffman-Goetz, L.andZajchowski, S., In vitro apoptosis of lymphocytes after exposure to levels of corticosterone observed following submaximal exercise. J. Sports Med. Phys. Fitness 1999. 39: 269-274.
    • (1999) J. Sports Med. Phys. Fitness , vol.39 , pp. 269-274
    • Hoffman-Goetz, L.1    Zajchowski, S.2
  • 57
    • 2342668267 scopus 로고    scopus 로고
    • Time-course of the murine lymphoid tissue involution during and following stressor exposure
    • Dominguez-Gerpe, L.andRey-Mendez, M., Time-course of the murine lymphoid tissue involution during and following stressor exposure. Life Sci. 1997. 61: 1019-1027.
    • (1997) Life Sci. , vol.61 , pp. 1019-1027
    • Dominguez-Gerpe, L.1    Rey-Mendez, M.2
  • 58
    • 25844517914 scopus 로고    scopus 로고
    • Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
    • Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J.et al., Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J. Exp. Med. 2005. 202: 885-891.
    • (2005) J. Exp. Med. , vol.202 , pp. 885-891
    • Ko, K.1    Yamazaki, S.2    Nakamura, K.3    Nishioka, T.4    Hirota, K.5    Yamaguchi, T.6    Shimizu, J.7
  • 59
  • 60
    • 0024424843 scopus 로고
    • Identical forms of the CD2 antigen expressed by mouse T and B lymphocytes
    • Altevogt, P., Michaelis, M.andKyewski, B., Identical forms of the CD2 antigen expressed by mouse T and B lymphocytes. Eur. J. Immunol. 1989. 19: 1509-1512.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 1509-1512
    • Altevogt, P.1    Michaelis, M.2    Kyewski, B.3
  • 61
    • 0141629753 scopus 로고    scopus 로고
    • Impact of psychological and endocrine factors on cytokine production of healthy elderly people
    • Luz, C., Dornelles, F., Preissler, T., Collaziol, D., da Cruz, I. M.andBauer, M. E., Impact of psychological and endocrine factors on cytokine production of healthy elderly people. Mech. Ageing Dev. 2003. 124: 887-895.
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 887-895
    • Luz, C.1    Dornelles, F.2    Preissler, T.3    Collaziol, D.4    da Cruz, I.M.5    Bauer, M.E.6
  • 63
    • 0034049874 scopus 로고    scopus 로고
    • Glucocorticoids in T cell development and function*
    • Ashwell, J. D., Lu, F. W.andVacchio, M. S., Glucocorticoids in T cell development and function*. Annu. Rev. Immunol. 2000. 18: 309-345.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 309-345
    • Ashwell, J.D.1    Lu, F.W.2    Vacchio, M.S.3
  • 64
    • 0033715726 scopus 로고    scopus 로고
    • Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
    • Purton, J. F., Boyd, R. L., Cole, T. J.andGodfrey, D. I., Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity 2000. 13: 179-186.
    • (2000) Immunity , vol.13 , pp. 179-186
    • Purton, J.F.1    Boyd, R.L.2    Cole, T.J.3    Godfrey, D.I.4
  • 65
    • 0036909641 scopus 로고    scopus 로고
    • Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice
    • Purton, J. F., Zhan, Y., Liddicoat, D. R., Hardy, C. L., Lew, A. M., Cole, T. J.andGodfrey, D. I., Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice. Eur. J. Immunol. 2002. 32: 3546-3555.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 3546-3555
    • Purton, J.F.1    Zhan, Y.2    Liddicoat, D.R.3    Hardy, C.L.4    Lew, A.M.5    Cole, T.J.6    Godfrey, D.I.7
  • 66
    • 0027162602 scopus 로고
    • Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
    • Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z.andRyu, S. Y., Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J. Immunol. 1993. 150: 5219-5230.
    • (1993) J. Immunol. , vol.150 , pp. 5219-5230
    • Daynes, R.A.1    Araneo, B.A.2    Ershler, W.B.3    Maloney, C.4    Li, G.Z.5    Ryu, S.Y.6
  • 67
    • 0029739151 scopus 로고    scopus 로고
    • Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults
    • Malarkey, W. B., Wu, H., Cacioppo, J. T., Malarkey, K. L., Poehlmann, K. M., Glaser, R.et al., Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults. Endocrine 1996. 5: 33-39.
    • (1996) Endocrine , vol.5 , pp. 33-39
    • Malarkey, W.B.1    Wu, H.2    Cacioppo, J.T.3    Malarkey, K.L.4    Poehlmann, K.M.5    Glaser, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.