Exogenous interleukin-1β restores impaired Langerhans cell migration in aged skin [5]

British Journal of Dermatology

Volumn 150, Issue 6, 2004, Pages 1217-1218

  Bhushan, M ^a   Cumberbatch, M ^b   Dearman, R J ^b   Kimber, I ^b   Griffiths, C E M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONTACT ALLERGEN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 1;

ADULT; AGED; CELL AGING; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPIDERMIS; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOSURVEILLANCE; LANGERHANS CELL; LETTER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN BIOPSY; SKIN CELL; SKIN INFECTION; SKIN SENSITIZATION; T LYMPHOCYTE; CELL MOTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CUTANEOUS PARAMETERS; DRUG EFFECT; PHYSIOLOGY;

ADULT; AGED; AGED, 80 AND OVER; CELL MOVEMENT; FEMALE; HUMANS; INTERLEUKIN-1; LANGERHANS CELLS; MALE; SKIN AGING;

EID: 3142712883     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2004.05973.x     Document Type: Letter

References (9)

1. Kimber I, Cumberbatch M, Dearman RJ et al. Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br J Dermatol 2000; 142: 401-12.
2. Sunderkotter C, Halden H, Luger TA. Aging and the skin immune system. Arch Dermatol 1997; 133: 1256-62.
3. Bhushan M, Cumberbatch M, Andrew SM et al. Tumour necrosis factor-α induced migration of human Langerhans cells: the influence of ageing. Br J Dermatol 2002; 146: 32-40.
4. Cumberbatch M, Griffiths CEM, Tucker SC et al. Tumour necrosis factor-α induces Langerhans cell migration in humans. Br J Dermatol 1999; 141: 192-200.
5. Cumberbatch M, Bhushan M, Dearman RJ et al. IL-1β-induced Langerhans cell migration and TNF-α production in human skin: regulation by lactoferrin. Clin Exp Immunol 2003; 132: 352-9.
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8. Shibaki A, Meunier L, Ra C et al. Differential responsiveness of Langerhans cell subsets of varying phenotypic states in normal human epidermis. J Invest Dermatol 1995; 104: 42-6.
9. Cumberbatch M, Dearman RJ, Kimber I. Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin 1β. Immunology 2002; 105: 466-77.