Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins

Free Radical Research

Volumn 34, Issue 5, 2001, Pages 485-497

  Vaya, Jacob ^a   Aviram, Michael ^b   Mahmood, Saeed ^a   Hayek, Tony ^b   Grenadir, Ehud ^b   Hoffman, Aaron ^b   Milo, Simcha ^b  

^a MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Atherosclerosis; E mice; HDL; Human lesion; LDL; Oxysterols

Indexed keywords

19 HYDROXYCHOLESTEROL; 25 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; 3,5,6 TRIHYDROXYCHOLESTEROL; 4BETA HYDROXYCHOLESTEROL; 5ALPHA 6ALPHA EPOXYCHOLESTEROL; 5BETA 6BETA EPOXYCHOLESTEROL; 7 OXOCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; APOLIPOPROTEIN E; CHOLESTANE; CHOLESTEROL DERIVATIVE; FATTY ACID; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; OXYSTEROL; STEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA DISEASE; ARTICLE; ATHERECTOMY; ATHEROSCLEROSIS; CAROTID ARTERY DISEASE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHOLESTEROL ESTERIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE COURSE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATION; SAMPLE; SERUM; TISSUE DISTRIBUTION;

EID: 0035007094     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100300431     Document Type: Article

References (48)

1. Atherosclerosis: Basic mechanisms. Oxidation, inflammation, and genetics
2. Angiotoxicity and atherogenicity of cholesterol oxides
3. Biological effects of oxysterols: Current status
4. The role of cholesterol oxidation products in the pathogenesis of atherosclerosis
5. Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol
6. Toxicity of oxysterols to human monocyte-macrophages
7. Breast fluid cholesterol and cholesterol β-epoxide concentrations in women with benign breast disease
8. Cholesterol oxidation derivatives and arterial endothelial damage
9. Oxysterol-induced apoptosis in human monocytic cell lines
10. Oxysterol-induced cell death in human leukemic T-cells correlates with oxysterol binding protein occupancy and is independent of glucocorticoid-induced apoptosis
11. Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes
12. Minimally modified low density lipoprotein stimulates monocyte endothelial cell interactions
13. Hydroxypropyl-β cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells
14. Lipids and oxidized lipids in human atherosclerotic lesions at different stages of development
15. Lipids and oxidized lipids in human atheroma and normal aorta
16. Cholesterol oxides in Indian ghee: Possible cause of unexplained high risk of atherosclerosis in Indian immigrant populations
17. Oxidative status of lipoproteins in coronary disease patients
18. Higher 7β-hydroxycholesterol in high cardiovascular risk population
19. Increased plasma 7β-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease
20. Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7β-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall
21. Cholesterol autoxidation in phospholipid membrane bilayers
22. Quantification of oxysterols in Dutch foods: Egg products and mixed diets
23. 2 techniques in vivo and in vitro
24. Probucol reduces plasma and aortic wall oxysterol levels in cholesterol fed rabbits independently of its plasma cholesterol lowering effect
25. Antioxidant treatment inhibits the development of intimal thickening after balloon injury of the aorta in hypercholesterolemic rabbits
26. 2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7β-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol
27. Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography /mass spectrometry
28. 7-ketocholesterol, a specific indicator of lipoprotein oxidation, and malondialdehyde in non-insulin dependent diabetes and peripheral vascular disease
29. Quantification of cholesterol oxidation products in plasma lipoproteins of fasted humans
30. Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients
31. Protein measurement with the Folin phenol reagent
32. Microsomal lipid peroxidation
33. Oxysterols and atherosclerosis
34. Free and esterified oxysterol: Formation during copper-oxidation of low density lipoprotein and uptake by macrophages
35. Varying susceptibility of different low density lipoprotein to oxidative modification
36. +2 ions: Identification of major products and their effects
37. Capillary gas chromatography quantification of cholesterol in copper-oxidised low-density lipoproteins
38. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper
39. Evidence for the presence of 7-hydroperoxycholest-5-en-3β-ol in oxidised human LDL
40. 7-Hydroperoxy-cholestesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque
41. The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation
42. Estimation of 26-hydroxycholesterol in serum by high-performance liquid chromatography and its measurement in patients with atherosclerosis
43. Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: Effects of vitamin E treatment
44. Autoantibodies against MDA-LDL in subjects with severe and minor atherosclerosis and healthy population controls
45. Lipoprotein oxidation and progression of carotid atherosclerosis
46. Plasma oxysterols and coronary atherosclerosis: A case control study
47. Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques
48. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans