-
1
-
-
84872363774
-
-
World Health Organization. Burden: mortality, morbidity and risk factors. Available at, Accessed September 2012
-
World Health Organization. Burden: mortality, morbidity and risk factors. Available at http://www. who. int/diabetes/facts/en/index. html. Accessed September 2012.
-
-
-
-
2
-
-
84872312876
-
-
World Health Organization. Facts and figures about diabetes. Available at, Accessed September 2012
-
World Health Organization. Facts and figures about diabetes. Available at http://www. who. int/mediacentre/factsheets/fs312/en/index. html. Accessed September 2012.
-
-
-
-
3
-
-
77649336781
-
Global healthcare expenditure on diabetes for 2010 and 2030
-
Zhang P, Zhang X, Brown J, et al. Global healthcare expenditure on diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010; 87: 293-301.
-
(2010)
Diabetes Res Clin Pract
, vol.87
, pp. 293-301
-
-
Zhang, P.1
Zhang, X.2
Brown, J.3
-
4
-
-
84865956943
-
Bariatric surgery to treat type 2 diabetes: what is the recent evidence?
-
van Gaal LF, De Block CE. Bariatric surgery to treat type 2 diabetes: what is the recent evidence? Curr Opin Endocrinol Diabetes Obes. 2012; 19: 352-8.
-
(2012)
Curr Opin Endocrinol Diabetes Obes
, vol.19
, pp. 352-358
-
-
van Gaal, L.F.1
de Block, C.E.2
-
5
-
-
84869031541
-
Metabolomics in diabetes research
-
doi: 10. 1530/JOE-12-0120
-
Friedrich N. Metabolomics in diabetes research. J Endocrinol. 2012. doi: 10. 1530/JOE-12-0120.
-
(2012)
J Endocrinol
-
-
Friedrich, N.1
-
6
-
-
80053991414
-
Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook
-
Dunn WB, Goodacre R, Neyses L, et al. Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook. Bioanalysis. 2011; 3: 2205-22.
-
(2011)
Bioanalysis
, vol.3
, pp. 2205-2222
-
-
Dunn, W.B.1
Goodacre, R.2
Neyses, L.3
-
7
-
-
78650315006
-
Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy
-
Dunn WB, Broadhurst DI, Atherton HJ, et al. Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem Soc Rev. 2011; 40: 387-426.
-
(2011)
Chem Soc Rev
, vol.40
, pp. 387-426
-
-
Dunn, W.B.1
Broadhurst, D.I.2
Atherton, H.J.3
-
8
-
-
47249129510
-
Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding?
-
Griffin JL, Vidal-Puig A. Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genome. 2008; 34: 1-5.
-
(2008)
Physiol Genome
, vol.34
, pp. 1-5
-
-
Griffin, J.L.1
Vidal-Puig, A.2
-
9
-
-
54549091125
-
Systems biology: metabonomics
-
Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature. 2008; 455: 1054-6.
-
(2008)
Nature
, vol.455
, pp. 1054-1056
-
-
Nicholson, J.K.1
Lindon, J.C.2
-
10
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
This article shows for the first time how high quality experimental design and suitably sized subject cohorts coupled with discovery-based metabolomics can be applied to identify putative prognostic metabolic biomarkers of disease risk
-
•• Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011; 17: 448-53. This article shows for the first time how high quality experimental design and suitably sized subject cohorts coupled with discovery-based metabolomics can be applied to identify putative prognostic metabolic biomarkers of disease risk.
-
(2011)
Nat Med
, vol.17
, pp. 448-453
-
-
Wang, T.J.1
Larson, M.G.2
Vasan, R.S.3
-
11
-
-
0014669160
-
Plasma amino acid levels and insulin secretion in obesity
-
Felig P, Marliss E, Cahill Jr GF. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med. 1969; 281: 811-6.
-
(1969)
N Engl J Med
, vol.281
, pp. 811-816
-
-
Felig, P.1
Marliss, E.2
Cahill Jr., G.F.3
-
12
-
-
79953329970
-
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
-
Rhee EP, Cheng S, Larson MG, et al. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011; 121: 1402-11.
-
(2011)
J Clin Invest
, vol.121
, pp. 1402-1411
-
-
Rhee, E.P.1
Cheng, S.2
Larson, M.G.3
-
13
-
-
84860439210
-
Interplay between lipids and branched-chain amino acids in development of insulin resistance
-
This article highlights the synergistic roles and interplay of BCAA and fatty acids in insulin resistance
-
• Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012; 15: 606-14. This article highlights the synergistic roles and interplay of BCAA and fatty acids in insulin resistance.
-
(2012)
Cell Metab
, vol.15
, pp. 606-614
-
-
Newgard, C.B.1
-
14
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
Newgard CB, An J, Bain JR, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009; 9: 311-26.
-
(2009)
Cell Metab
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
An, J.2
Bain, J.R.3
-
15
-
-
77953667219
-
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
-
Shah SH, Bain JR, Muehlbauer MJ, et al. Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ Cardiovasc Genet. 2010; 3: 207-14.
-
(2010)
Circ Cardiovasc Genet
, vol.3
, pp. 207-214
-
-
Shah, S.H.1
Bain, J.R.2
Muehlbauer, M.J.3
-
16
-
-
79955387227
-
Differential metabolic impact of gastric bypass surgery vs dietary intervention in obese diabetic subjects despite identical weight loss
-
Laferrere B, Reilly D, Arias S, et al. Differential metabolic impact of gastric bypass surgery vs dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med. 2011; 3: 80re2.
-
(2011)
Sci Transl Med
, vol.3
-
-
Laferrere, B.1
Reilly, D.2
Arias, S.3
-
17
-
-
84859073302
-
Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation
-
Mihalik SJ, Michaliszyn SF, de las Heras J, et al. Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care. 2012; 35: 605-11.
-
(2012)
Diabetes Care
, vol.35
, pp. 605-611
-
-
Mihalik, S.J.1
Michaliszyn, S.F.2
de las Heras, J.3
-
18
-
-
84862282554
-
Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state
-
Adams SH. Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv Nutr. 2011; 2: 445-56.
-
(2011)
Adv Nutr
, vol.2
, pp. 445-456
-
-
Adams, S.H.1
-
19
-
-
79959453305
-
Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism
-
Macotela Y, Emanuelli B, Bang AM, et al. Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One. 2011; 6: e21187.
-
(2011)
PLoS One
, vol.6
-
-
Macotela, Y.1
Emanuelli, B.2
Bang, A.M.3
-
20
-
-
79960901784
-
Pancreatic beta-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis
-
Collier JJ, Burke SJ, Eisenhauer ME, et al. Pancreatic beta-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis. PLoS One. 2011; 6: e22485.
-
(2011)
PLoS One
, vol.6
-
-
Collier, J.J.1
Burke, S.J.2
Eisenhauer, M.E.3
-
21
-
-
79952836464
-
A lipidomic screen of palmitate-treated MIN6 beta-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
-
Boslem E, MacIntosh G, Preston AM, et al. A lipidomic screen of palmitate-treated MIN6 beta-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking. Biochem J. 2011; 435: 267-76.
-
(2011)
Biochem J
, vol.435
, pp. 267-276
-
-
Boslem, E.1
MacIntosh, G.2
Preston, A.M.3
-
22
-
-
79952821873
-
Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines
-
Spegel P, Malmgren S, Sharoyko VV, et al. Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines. Biochem J. 2011; 435: 277-84.
-
(2011)
Biochem J
, vol.435
, pp. 277-284
-
-
Spegel, P.1
Malmgren, S.2
Sharoyko, V.V.3
-
23
-
-
78651397321
-
Aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor-1ß plays a critical role in maintaining glucose-stimulated anaplerosis and insulin release from pancreatic ß-cells
-
Pillai R, Huypens P, Huang M, et al. Aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor-1ß plays a critical role in maintaining glucose-stimulated anaplerosis and insulin release from pancreatic ß-cells. J Biol Chem. 2011; 286: 1014-24.
-
(2011)
J Biol Chem
, vol.286
, pp. 1014-1024
-
-
Pillai, R.1
Huypens, P.2
Huang, M.3
-
24
-
-
80055090409
-
Metabolic regulation in progression to autoimmune diabetes
-
This article describes a reverse translation approach to study the pathogenesis of autoimmune diabetes. The lipidomic patterns observed in nonobese prediabetic mice that progressed to develop autoimmune diabetes were similar to prediabetic children in the Type 1 Diabetes Prediction and Prevention project (DIPP) study
-
• Sysi-Aho M, Ermolov A, Gopalacharyulu PV, et al. Metabolic regulation in progression to autoimmune diabetes. PLoS Comput Biol. 2011; 7: e1002257. This article describes a reverse translation approach to study the pathogenesis of autoimmune diabetes. The lipidomic patterns observed in nonobese prediabetic mice that progressed to develop autoimmune diabetes were similar to prediabetic children in the Type 1 Diabetes Prediction and Prevention project (DIPP) study.
-
(2011)
PLoS Comput Biol
, vol.7
-
-
Sysi-Aho, M.1
Ermolov, A.2
Gopalacharyulu, P.V.3
-
25
-
-
59649105735
-
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
-
Oresic M, Simell S, Sysi-Aho M, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med. 2008; 205: 2975-84.
-
(2008)
J Exp Med
, vol.205
, pp. 2975-2984
-
-
Oresic, M.1
Simell, S.2
Sysi-Aho, M.3
-
26
-
-
84860587743
-
Concordance of changes in metabolic pathways based on plasma metabolomics and skeletal muscle transcriptomics in type 1 diabetes
-
Dutta T, Chai HS, Ward LE, et al. Concordance of changes in metabolic pathways based on plasma metabolomics and skeletal muscle transcriptomics in type 1 diabetes. Diabetes. 2012; 61: 1004-16.
-
(2012)
Diabetes
, vol.61
, pp. 1004-1016
-
-
Dutta, T.1
Chai, H.S.2
Ward, L.E.3
-
27
-
-
84860469666
-
Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer
-
Ament Z, Masoodi M, Griffin JL. Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. Genome Med. 2012; 4: 32.
-
(2012)
Genome Med
, vol.4
, pp. 32
-
-
Ament, Z.1
Masoodi, M.2
Griffin, J.L.3
-
28
-
-
84856384840
-
Metabolomic biomarkers of impaired glucose tolerance and type 2 diabetes mellitus with a potential for risk stratification in women with polycystic ovary syndrome
-
Galazis N, Iacovou C, Haoula Z, Atiomo W. Metabolomic biomarkers of impaired glucose tolerance and type 2 diabetes mellitus with a potential for risk stratification in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2012; 160: 121-30.
-
(2012)
Eur J Obstet Gynecol Reprod Biol
, vol.160
, pp. 121-130
-
-
Galazis, N.1
Iacovou, C.2
Haoula, Z.3
Atiomo, W.4
-
29
-
-
84861221022
-
Sphingomyelin is associated with kidney disease in type 1 diabetes (the FinnDiane study)
-
Makinen VP, Tynkkynen T, Soininen P, et al. Sphingomyelin is associated with kidney disease in type 1 diabetes (the FinnDiane study). Metabolomics. 2012; 8: 369-75.
-
(2012)
Metabolomics
, vol.8
, pp. 369-375
-
-
Makinen, V.P.1
Tynkkynen, T.2
Soininen, P.3
-
30
-
-
77956234760
-
Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet
-
Boini KM, Zhang C, Xia M, Poklis JL, Li PL. Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet. J Pharmacol Exp Ther. 2010; 334: 839-46.
-
(2010)
J Pharmacol Exp Ther
, vol.334
, pp. 839-846
-
-
Boini, K.M.1
Zhang, C.2
Xia, M.3
Poklis, J.L.4
Li, P.L.5
-
31
-
-
84855894622
-
Discovery of early-stage biomarkers for diabetic kidney disease using MS-based metabolomics (FinnDiane study)
-
van der Kloet FM, Tempels FW, Ismail N, et al. Discovery of early-stage biomarkers for diabetic kidney disease using MS-based metabolomics (FinnDiane study). Metabolomics. 2012; 8: 109-19.
-
(2012)
Metabolomics
, vol.8
, pp. 109-119
-
-
van der Kloet, F.M.1
Tempels, F.W.2
Ismail, N.3
-
32
-
-
84856709532
-
A metabolomic study of low estimated GFR in nonproteinuric type 2 diabetes mellitus
-
Ng DP, Salim A, Liu Y, et al. A metabolomic study of low estimated GFR in nonproteinuric type 2 diabetes mellitus. Diabetologia. 2012; 55: 499-508.
-
(2012)
Diabetologia
, vol.55
, pp. 499-508
-
-
Ng, D.P.1
Salim, A.2
Liu, Y.3
-
33
-
-
80052148776
-
Phospholipidomic identification of potential plasma biomarkers associated with type 2 diabetes mellitus and diabetic nephropathy
-
Zhu C, Liang QL, Hu P, Wang YM, Luo GA. Phospholipidomic identification of potential plasma biomarkers associated with type 2 diabetes mellitus and diabetic nephropathy. Talanta. 2011; 85: 1711-20.
-
(2011)
Talanta
, vol.85
, pp. 1711-1720
-
-
Zhu, C.1
Liang, Q.L.2
Hu, P.3
Wang, Y.M.4
Luo, G.A.5
-
34
-
-
84859643710
-
The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes
-
Ha CY, Kim JY, Paik JK, et al. The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes. Clin Endocrinol. 2012; 76: 674-82.
-
(2012)
Clin Endocrinol
, vol.76
, pp. 674-682
-
-
Ha, C.Y.1
Kim, J.Y.2
Paik, J.K.3
-
35
-
-
83955163615
-
Intrarenal metabolomics reveals the association of local organic toxins with the progression of diabetic kidney disease
-
Zhao T, Zhang H, Zhang X, et al. Intrarenal metabolomics reveals the association of local organic toxins with the progression of diabetic kidney disease. J Pharm Biomed Anal. 2012; 60: 32-43.
-
(2012)
J Pharm Biomed Anal
, vol.60
, pp. 32-43
-
-
Zhao, T.1
Zhang, H.2
Zhang, X.3
-
36
-
-
79957581759
-
Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus
-
Patterson AD, Bonzo JA, Li F, et al. Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem. 2011; 286: 19511-22.
-
(2011)
J Biol Chem
, vol.286
, pp. 19511-19522
-
-
Patterson, A.D.1
Bonzo, J.A.2
Li, F.3
-
37
-
-
84863815920
-
Metabolomics approach for analyzing the effects of exercise in subjects with type 1 diabetes mellitus
-
Brugnara L, Vinaixa M, Murillo S, et al. Metabolomics approach for analyzing the effects of exercise in subjects with type 1 diabetes mellitus. PLoS One. 2012; 7: e40600.
-
(2012)
PLoS One
, vol.7
-
-
Brugnara, L.1
Vinaixa, M.2
Murillo, S.3
-
38
-
-
84862215515
-
Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics
-
Nissim I, Horyn O, Daikhin Y, et al. Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics. Biochem J. 2012; 444: 537-51.
-
(2012)
Biochem J
, vol.444
, pp. 537-551
-
-
Nissim, I.1
Horyn, O.2
Daikhin, Y.3
-
39
-
-
84856426996
-
Stable isotope-resolved metabolomics and applications for drug development
-
Fan TW, Lorkiewicz PK, Sellers K, et al. Stable isotope-resolved metabolomics and applications for drug development. Pharmacol Ther. 2012; 133: 366-91.
-
(2012)
Pharmacol Ther
, vol.133
, pp. 366-391
-
-
Fan, T.W.1
Lorkiewicz, P.K.2
Sellers, K.3
-
40
-
-
79959861040
-
TARDIS-based microbial metabolomics: time and relative differences in systems
-
Winder CL, Dunn WB, Goodacre R. TARDIS-based microbial metabolomics: time and relative differences in systems. Trends Microbiol. 2011; 19: 315-22.
-
(2011)
Trends Microbiol
, vol.19
, pp. 315-322
-
-
Winder, C.L.1
Dunn, W.B.2
Goodacre, R.3
-
41
-
-
84861914251
-
Selective divalent copper chelation for the treatment of diabetes mellitus
-
Cooper GJ. Selective divalent copper chelation for the treatment of diabetes mellitus. Curr Med Chem. 2012; 19: 2828-60.
-
(2012)
Curr Med Chem
, vol.19
, pp. 2828-2860
-
-
Cooper, G.J.1
-
42
-
-
84860463899
-
Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)
-
Ugarte M, Brown M, Hollywood KA, et al. Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). Genome Med. 2012; 4: 35.
-
(2012)
Genome Med.
, vol.4
, pp. 35
-
-
Ugarte, M.1
Brown, M.2
Hollywood, K.A.3
-
43
-
-
84858419687
-
Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine
-
McKillop AM, Flatt PR. Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine. Diabetes Care. 2011; 34: 2624-30.
-
(2011)
Diabetes Care
, vol.34
, pp. 2624-2630
-
-
McKillop, A.M.1
Flatt, P.R.2
-
44
-
-
84860440529
-
Genome-wide association studies with metabolomics
-
Adamski J. Genome-wide association studies with metabolomics. Genome Med. 2012; 4: 34.
-
(2012)
Genome Med.
, vol.4
, pp. 34
-
-
Adamski, J.1
-
45
-
-
80054969621
-
A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology
-
Bordbar A, Feist AM, Usaite-Black R, et al. A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. BMC Syst Biol. 2011; 5: 180.
-
(2011)
BMC Syst Biol
, vol.5
, pp. 180
-
-
Bordbar, A.1
Feist, A.M.2
Usaite-Black, R.3
-
46
-
-
84858433310
-
Personal omics profiling reveals dynamic molecular and medical phenotypes
-
Chen R, Mias GI, Li-Pook-Than J, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012; 148: 1293-307.
-
(2012)
Cell
, vol.148
, pp. 1293-1307
-
-
Chen, R.1
Mias, G.I.2
Li-Pook-Than, J.3
-
47
-
-
79551489208
-
Personalized medicine in diabetes
-
Malandrino N, Smith RJ. Personalized medicine in diabetes. Clin Chem. 2011; 57: 231-40.
-
(2011)
Clin Chem
, vol.57
, pp. 231-240
-
-
Malandrino, N.1
Smith, R.J.2
-
48
-
-
79959378842
-
Biomarkers for the prediction of type 2 diabetes and cardiovascular disease
-
Herder C, Karakas M, Koenig W. Biomarkers for the prediction of type 2 diabetes and cardiovascular disease. Clin Pharmacol Ther. 2011; 90: 52-66.
-
(2011)
Clin Pharmacol Ther
, vol.90
, pp. 52-66
-
-
Herder, C.1
Karakas, M.2
Koenig, W.3
-
49
-
-
79953737553
-
An amino acid profile to predict diabetes?
-
Langenberg C, Savage DB. An amino acid profile to predict diabetes? Nat Med. 2011; 17: 418-20.
-
(2011)
Nat Med
, vol.17
, pp. 418-420
-
-
Langenberg, C.1
Savage, D.B.2
|