On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices

Analytical Chemistry

Volumn 83, Issue 1, 2011, Pages 84-91

  Van Midwoud, Paul M ^a   Janssen, Joost ^a   Merema, Marjolijn T ^a   De Graaf, Inge A M ^a   Groothuis, Geny M M ^a   Verpoorte, Elisabeth ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

7-HYDROXYCOUMARIN; CONCENTRATION DEPENDENCE; CONCENTRATION-DEPENDENT; DICLOFENAC; DICLOFENAC-ACYL-GLUCURONIDE; DRUG METABOLISMS; DRUG-DRUG INTERACTIONS; FREEZE-THAW; GLUCURONIDES; HIGH CONCENTRATION; HPLC ANALYSIS; HPLC-UV; IC50 VALUE; INHIBITORY EFFECT; LIVER SLICES; MICRO FLUIDIC SYSTEM; MICRO-FLUIDIC DEVICES; ON-LINE ANALYSIS; ON-LINE DETECTION; ONLINE MONITORING; PERFUSION MEDIUM; PHASE II; POLYDIMETHYLSILOXANE PDMS; PRECISION CUT; RAPID SWITCHING; REACTIVE METABOLITES; SIMULTANEOUS ANALYSIS; SOLVENT CONTROL; STABLE PHASE; SYRINGE PUMPS; TISSUE FUNCTION; UV DETECTION;

BIOMOLECULES; CONCENTRATION (PROCESS); DRUG INTERACTIONS; ENZYME INHIBITION; FLUIDIC DEVICES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; METABOLITES; MICROFLUIDICS; PUMPS; SUBSTRATES;

METABOLISM;

7-HYDROXYCOUMARIN GLUCURONIDE; DICLOFENAC; DRUG; EOSINE BLUE; UMBELLIFERONE DERIVATIVE; UMBELLIFERONE GLUCURONIDE;

ANIMAL; ARTICLE; CYTOLOGY; DRUG DETOXIFICATION; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIVER; MALE; METABOLISM; METHODOLOGY; MICROTOMY; ONLINE SYSTEM; RAT; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICLOFENAC; EOSINE I BLUISH; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MICROTOMY; ONLINE SYSTEMS; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR; UMBELLIFERONES;

EID: 78650775877     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac1018638     Document Type: Article

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