Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes

Drug Metabolism and Disposition

Volumn 31, Issue 5, 2003, Pages 631-636

  Dalmadi, Balázs ^a   Leibinger, János ^a   Szeberényi, Szabolcs ^a   Borbás, Tímea ^a   Farkas, Sándor ^a   Szombathelyi, Zsolt ^a   Tihanyi, Károly ^a  

^a GEDEON RICHTER LTD   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; 1 BENZYLIMIDAZOLE; BUFURALOL; CARBONYL REDUCTASE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DIMETHYLANILINE MONOOXYGENASE; METHYL 4 TOLYL SULFIDE; MICROSOME ENZYME; PROADIFEN; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; TOLPERISONE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSFORMATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METHYLATION; PRIORITY JOURNAL;

ANTIBODIES; AREA UNDER CURVE; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYLATION; ISOENZYMES; MICROSOMES, LIVER; MUSCLE RELAXANTS, CENTRAL; PROTEIN BINDING; SUBSTRATE SPECIFICITY; TOLPERISONE;

EID: 0037403410     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.5.631     Document Type: Conference Paper

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