The acetaminophen regioisomer 3'-hydroxyacetanilide inhibits and covalently binds to cytochrome P450 2E1

Toxicology Letters

Volumn 94, Issue 1, 1998, Pages 65-71

  Halmes, N Christine ^a   Samokyszyn, Victor M ^a   Hinton, Thomas W ^a   Hinson, Jack A ^a   Pumford, Neil R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

3' Hydroxyacetanilide; Acetaminophen; Cytochrome P450 2E1; Protein covalent binding

Indexed keywords

CYTOCHROME P450; LIVER PROTEIN; METACETAMOL; PARACETAMOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ISOTOPE LABELING; LIVER MICROSOME; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ACETANILIDES; ANIMALS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; LIVER; MALE; MICE; MICROSOMES, LIVER; PROTEIN BINDING;

ANIMALIA;

EID: 0032536073     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(97)00100-8     Document Type: Article

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